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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CTBP2_HUMAN (P56545)

Summary

This is the summary of UniProt entry CTBP2_HUMAN (P56545).

Description: C-terminal-binding protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 445 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam 2-Hacid_dh 36 358
Pfam 2-Hacid_dh_C 139 323
low_complexity n/a 240 253
low_complexity n/a 333 348
disorder n/a 336 337
disorder n/a 405 408
disorder n/a 412 445

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P56545. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI
50
51
LKDLATVAFC DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV
100
101
IVRIGSGYDN VDIKAAGELG IAVCNIPSAA VEETADSTIC HILNLYRRNT
150
151
WLYQALREGT RVQSVEQIRE VASGAARIRG ETLGLIGFGR TGQAVAVRAK
200
201
AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS LHCNLNEHNH
250
251
HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES
300
301
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP
350
351
ESLRNCVNKE FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP
400
401
AAMEGIIPGG IPVTHNLPTV AHPSQAPSPN QPTKHGDNRE HPNEQ     
445
 

Show the unformatted sequence.

Checksums:
CRC64:0A8C21CEB36807FA
MD5:3bdea62a982806d6454d5f752ac78629

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
2-Hacid_dh 36 - 358 2OME A 36 - 358 Jmol OpenAstexViewer
B 36 - 358 Jmol OpenAstexViewer
C 36 - 358 Jmol OpenAstexViewer
D 36 - 358 Jmol OpenAstexViewer
E 36 - 358 Jmol OpenAstexViewer
F 36 - 358 Jmol OpenAstexViewer
G 36 - 358 Jmol OpenAstexViewer
H 36 - 358 Jmol OpenAstexViewer
4LCJ A 36 - 358 Jmol OpenAstexViewer
B 36 - 358 Jmol OpenAstexViewer
C 36 - 358 Jmol OpenAstexViewer
D 36 - 358 Jmol OpenAstexViewer
E 36 - 358 Jmol OpenAstexViewer
F 36 - 358 Jmol OpenAstexViewer
G 36 - 358 Jmol OpenAstexViewer
H 36 - 358 Jmol OpenAstexViewer
2-Hacid_dh_C 139 - 323 2OME A 139 - 323 Jmol OpenAstexViewer
B 139 - 323 Jmol OpenAstexViewer
C 139 - 323 Jmol OpenAstexViewer
D 139 - 323 Jmol OpenAstexViewer
E 139 - 323 Jmol OpenAstexViewer
F 139 - 323 Jmol OpenAstexViewer
G 139 - 323 Jmol OpenAstexViewer
H 139 - 323 Jmol OpenAstexViewer
4LCJ A 139 - 323 Jmol OpenAstexViewer
B 139 - 323 Jmol OpenAstexViewer
C 139 - 323 Jmol OpenAstexViewer
D 139 - 323 Jmol OpenAstexViewer
E 139 - 323 Jmol OpenAstexViewer
F 139 - 323 Jmol OpenAstexViewer
G 139 - 323 Jmol OpenAstexViewer
H 139 - 323 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.