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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RGS8_HUMAN (P57771)

Summary

This is the summary of UniProt entry RGS8_HUMAN (P57771).

Description: Regulator of G-protein signaling 8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 180 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam RGS 56 171
disorder n/a 127 128
low_complexity n/a 170 179

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P57771. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA
50
51
TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK
100
101
LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV
150
151
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS                      
180
 

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Checksums:
CRC64:198965B4C27F64C9
MD5:99f470573d930af52f035c7b1f23d029

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RGS 56 - 171 2IHD A 56 - 171 Jmol OpenAstexViewer
2ODE B 56 - 171 Jmol OpenAstexViewer
D 56 - 171 Jmol OpenAstexViewer
5DO9 B 56 - 171 Jmol OpenAstexViewer
D 56 - 171 Jmol OpenAstexViewer
F 56 - 171 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.