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36  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPIKE_CVHSA (P59594)

Summary

This is the summary of UniProt entry SPIKE_CVHSA (P59594).

Description: Spike glycoprotein
Source organism: Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) (NCBI taxonomy ID 227859)
View Pfam proteome data.
Length: 1255 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 13
Pfam Spike_NTD 82 284
low_complexity n/a 110 124
Pfam Spike_rec_bind 317 569
Pfam Corona_S2 648 1252
low_complexity n/a 861 874
coiled_coil n/a 1158 1185
transmembrane n/a 1196 1218
low_complexity n/a 1214 1225

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P59594. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFIFLLFLTL TSGSDLDRCT TFDDVQAPNY TQHTSSMRGV YYPDEIFRSD
50
51
TLYLTQDLFL PFYSNVTGFH TINHTFGNPV IPFKDGIYFA ATEKSNVVRG
100
101
WVFGSTMNNK SQSVIIINNS TNVVIRACNF ELCDNPFFAV SKPMGTQTHT
150
151
MIFDNAFNCT FEYISDAFSL DVSEKSGNFK HLREFVFKNK DGFLYVYKGY
200
201
QPIDVVRDLP SGFNTLKPIF KLPLGINITN FRAILTAFSP AQDIWGTSAA
250
251
AYFVGYLKPT TFMLKYDENG TITDAVDCSQ NPLAELKCSV KSFEIDKGIY
300
301
QTSNFRVVPS GDVVRFPNIT NLCPFGEVFN ATKFPSVYAW ERKKISNCVA
350
351
DYSVLYNSTF FSTFKCYGVS ATKLNDLCFS NVYADSFVVK GDDVRQIAPG
400
401
QTGVIADYNY KLPDDFMGCV LAWNTRNIDA TSTGNYNYKY RYLRHGKLRP
450
451
FERDISNVPF SPDGKPCTPP ALNCYWPLND YGFYTTTGIG YQPYRVVVLS
500
501
FELLNAPATV CGPKLSTDLI KNQCVNFNFN GLTGTGVLTP SSKRFQPFQQ
550
551
FGRDVSDFTD SVRDPKTSEI LDISPCSFGG VSVITPGTNA SSEVAVLYQD
600
601
VNCTDVSTAI HADQLTPAWR IYSTGNNVFQ TQAGCLIGAE HVDTSYECDI
650
651
PIGAGICASY HTVSLLRSTS QKSIVAYTMS LGADSSIAYS NNTIAIPTNF
700
701
SISITTEVMP VSMAKTSVDC NMYICGDSTE CANLLLQYGS FCTQLNRALS
750
751
GIAAEQDRNT REVFAQVKQM YKTPTLKYFG GFNFSQILPD PLKPTKRSFI
800
801
EDLLFNKVTL ADAGFMKQYG ECLGDINARD LICAQKFNGL TVLPPLLTDD
850
851
MIAAYTAALV SGTATAGWTF GAGAALQIPF AMQMAYRFNG IGVTQNVLYE
900
901
NQKQIANQFN KAISQIQESL TTTSTALGKL QDVVNQNAQA LNTLVKQLSS
950
951
NFGAISSVLN DILSRLDKVE AEVQIDRLIT GRLQSLQTYV TQQLIRAAEI
1000
1001
RASANLAATK MSECVLGQSK RVDFCGKGYH LMSFPQAAPH GVVFLHVTYV
1050
1051
PSQERNFTTA PAICHEGKAY FPREGVFVFN GTSWFITQRN FFSPQIITTD
1100
1101
NTFVSGNCDV VIGIINNTVY DPLQPELDSF KEELDKYFKN HTSPDVDLGD
1150
1151
ISGINASVVN IQKEIDRLNE VAKNLNESLI DLQELGKYEQ YIKWPWYVWL
1200
1201
GFIAGLIAIV MVTILLCCMT SCCSCLKGAC SCGSCCKFDE DDSEPVLKGV
1250
1251
KLHYT                                                 
1255
 

Show the unformatted sequence.

Checksums:
CRC64:1C49ACA2CFD38FC0
MD5:886b8a592d15ef58417293f780cb135f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Corona_S2 1141 - 1193 2FXP A 3 - 55 Jmol OpenAstexViewer
B 3 - 55 Jmol OpenAstexViewer
C 3 - 55 Jmol OpenAstexViewer
1142 - 1183 2BEZ F 1142 - 1183 Jmol OpenAstexViewer
1148 - 1193 2BEQ D 1148 - 1193 Jmol OpenAstexViewer
E 1148 - 1193 Jmol OpenAstexViewer
F 1148 - 1193 Jmol OpenAstexViewer
1150 - 1183 1ZV8 H 1 - 34 Jmol OpenAstexViewer
1150 - 1187 1ZV7 A 1 - 38 Jmol OpenAstexViewer
1152 - 1185 1ZV8 L 3 - 36 Jmol OpenAstexViewer
1153 - 1182 1ZV8 F 4 - 33 Jmol OpenAstexViewer
J 4 - 33 Jmol OpenAstexViewer
1153 - 1185 1ZV7 B 4 - 36 Jmol OpenAstexViewer
1154 - 1180 1ZV8 B 5 - 31 Jmol OpenAstexViewer
1154 - 1182 1ZV8 D 5 - 33 Jmol OpenAstexViewer
1185 - 1202 2RUN A 1 - 18 Jmol OpenAstexViewer
648 - 1058 5WRG A 648 - 1058 Jmol OpenAstexViewer
B 648 - 1058 Jmol OpenAstexViewer
C 648 - 1058 Jmol OpenAstexViewer
648 - 1104 5X58 A 648 - 1104 Jmol OpenAstexViewer
B 648 - 1104 Jmol OpenAstexViewer
C 648 - 1104 Jmol OpenAstexViewer
5X5B A 648 - 1104 Jmol OpenAstexViewer
B 648 - 1104 Jmol OpenAstexViewer
C 648 - 1104 Jmol OpenAstexViewer
648 - 1120 5XLR A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
6CRV A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
6CRW A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
6CRX A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
6CRZ A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
6CS0 A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
6CS1 A 648 - 1120 Jmol OpenAstexViewer
B 648 - 1120 Jmol OpenAstexViewer
C 648 - 1120 Jmol OpenAstexViewer
648 - 1127 6CS2 B 648 - 1127 Jmol OpenAstexViewer
648 - 1129 6CS2 A 648 - 1129 Jmol OpenAstexViewer
C 648 - 1129 Jmol OpenAstexViewer
758 - 821 5XJK A 2 - 65 Jmol OpenAstexViewer
770 - 788 2RUM A 1 - 19 Jmol OpenAstexViewer
873 - 888 2RUO A 1 - 16 Jmol OpenAstexViewer
890 - 973 1WYY A 890 - 973 Jmol OpenAstexViewer
892 - 973 1WYY B 892 - 973 Jmol OpenAstexViewer
896 - 972 2BEZ C 896 - 972 Jmol OpenAstexViewer
901 - 947 1WNC D 901 - 947 Jmol OpenAstexViewer
F 901 - 947 Jmol OpenAstexViewer
901 - 948 1WNC E 901 - 948 Jmol OpenAstexViewer
901 - 949 1ZV8 A 1 - 49 Jmol OpenAstexViewer
E 1 - 49 Jmol OpenAstexViewer
I 1 - 49 Jmol OpenAstexViewer
901 - 950 1ZV8 G 1 - 50 Jmol OpenAstexViewer
K 1 - 50 Jmol OpenAstexViewer
902 - 947 1WNC A 902 - 947 Jmol OpenAstexViewer
B 902 - 947 Jmol OpenAstexViewer
C 902 - 947 Jmol OpenAstexViewer
1ZV8 C 2 - 47 Jmol OpenAstexViewer
914 - 949 2BEQ A 914 - 949 Jmol OpenAstexViewer
B 914 - 949 Jmol OpenAstexViewer
C 914 - 949 Jmol OpenAstexViewer
940 - 973 1ZVB A 1 - 34 Jmol OpenAstexViewer
C 1 - 34 Jmol OpenAstexViewer
941 - 973 1ZVB B 2 - 34 Jmol OpenAstexViewer
Spike_NTD 261 - 284 5WRG A 261 - 284 Jmol OpenAstexViewer
B 261 - 284 Jmol OpenAstexViewer
C 261 - 284 Jmol OpenAstexViewer
82 - 284 5X4S A 82 - 284 Jmol OpenAstexViewer
5X58 A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
5X5B A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
5XLR A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CRV A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CRW A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CRX A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CRZ A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CS0 A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CS1 A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
6CS2 A 82 - 284 Jmol OpenAstexViewer
B 82 - 284 Jmol OpenAstexViewer
C 82 - 284 Jmol OpenAstexViewer
Spike_rec_bind 317 - 569 5WRG A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
5X58 A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
5X5B B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
5XLR A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
6CRW A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
6CRX A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
6CRZ A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
6CS0 A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
6CS1 A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
6CS2 A 317 - 569 Jmol OpenAstexViewer
B 317 - 569 Jmol OpenAstexViewer
C 317 - 569 Jmol OpenAstexViewer
318 - 505 2GHW C 318 - 505 Jmol OpenAstexViewer
319 - 509 2GHW A 319 - 509 Jmol OpenAstexViewer
320 - 502 2GHV C 320 - 502 Jmol OpenAstexViewer
E 320 - 502 Jmol OpenAstexViewer
321 - 512 2DD8 S 321 - 512 Jmol OpenAstexViewer
322 - 569 5X5B A 322 - 569 Jmol OpenAstexViewer
323 - 501 3BGF S 323 - 501 Jmol OpenAstexViewer
323 - 502 2AJF E 323 - 502 Jmol OpenAstexViewer
F 323 - 502 Jmol OpenAstexViewer
3BGF A 323 - 502 Jmol OpenAstexViewer
3SCI E 323 - 502 Jmol OpenAstexViewer
F 323 - 502 Jmol OpenAstexViewer
3SCJ E 323 - 502 Jmol OpenAstexViewer
F 323 - 502 Jmol OpenAstexViewer
324 - 502 3D0G E 324 - 502 Jmol OpenAstexViewer
F 324 - 502 Jmol OpenAstexViewer
3D0H E 324 - 502 Jmol OpenAstexViewer
F 324 - 502 Jmol OpenAstexViewer
3D0I E 324 - 502 Jmol OpenAstexViewer
F 324 - 502 Jmol OpenAstexViewer
3SCK E 324 - 502 Jmol OpenAstexViewer
F 324 - 502 Jmol OpenAstexViewer
3SCL E 324 - 502 Jmol OpenAstexViewer
F 324 - 502 Jmol OpenAstexViewer
515 - 569 6CRV A 515 - 569 Jmol OpenAstexViewer
B 515 - 569 Jmol OpenAstexViewer
C 515 - 569 Jmol OpenAstexViewer