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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DEF1_HUMAN (P59665)

Summary

This is the summary of UniProt entry DEF1_HUMAN (P59665).

Description: Neutrophil defensin 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 94 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Defensin_propep 1 52
sig_p n/a 1 19
low_complexity n/a 4 19
Pfam Defensin_1 66 94

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P59665. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIAADI PEVVVSLAWD
50
51
ESLAPKHPGS RKNMACYCRI PACIAGERRY GTCIYQGRLW AFCC      
94
 

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Checksums:
CRC64:0E0F8E95737396FA
MD5:98b6527329510b2e34c3a3aaf0470c5a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Defensin_1 66 - 94 2KHT A 2 - 30 Show 3D Structure View in InterPro
2PM1 A 2 - 30 Show 3D Structure View in InterPro
3GNY A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3H6C A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3HJ2 A 5 - 33 Show 3D Structure View in InterPro
B 5 - 33 Show 3D Structure View in InterPro
3HJD A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3LO1 A 2 - 30 Show 3D Structure View in InterPro
3LO2 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3LO4 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3LO6 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3LO9 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
3LOE A 2 - 30 Show 3D Structure View in InterPro
3LVX A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
4DU0 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
C 2 - 30 Show 3D Structure View in InterPro
D 2 - 30 Show 3D Structure View in InterPro
4LB1 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
D 2 - 30 Show 3D Structure View in InterPro
E 2 - 30 Show 3D Structure View in InterPro
4LB7 A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
D 2 - 30 Show 3D Structure View in InterPro
E 2 - 30 Show 3D Structure View in InterPro
4LBB A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
4LBF A 2 - 30 Show 3D Structure View in InterPro
B 2 - 30 Show 3D Structure View in InterPro
C 2 - 30 Show 3D Structure View in InterPro
D 2 - 30 Show 3D Structure View in InterPro
E 2 - 30 Show 3D Structure View in InterPro
F 2 - 30 Show 3D Structure View in InterPro
G 2 - 30 Show 3D Structure View in InterPro
H 2 - 30 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;