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22  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TPIS_HUMAN (P60174)

Summary

This is the summary of UniProt entry TPIS_HUMAN (P60174).

Description: Triosephosphate isomerase {ECO:0000305|PubMed:18562316}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 249 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam TIM 7 248
disorder n/a 176 177

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P60174. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID
50
51
FARQKLDPKI AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVLGHSERR
100
101
HVFGESDELI GQKVAHALAE GLGVIACIGE KLDEREAGIT EKVVFEQTKV
150
151
IADNVKDWSK VVLAYEPVWA IGTGKTATPQ QAQEVHEKLR GWLKSNVSDA
200
201
VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE FVDIINAKQ 
249
 

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Checksums:
CRC64:73844175635F858E
MD5:a8d44fc2c980a7677a3b54788d0fa323

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TIM 23 - 37 1KLG C 23 - 37 Show 3D Structure View in InterPro
1KLU C 23 - 37 Show 3D Structure View in InterPro
2IAM P 23 - 37 Show 3D Structure View in InterPro
2IAN C 23 - 37 Show 3D Structure View in InterPro
H 23 - 37 Show 3D Structure View in InterPro
M 23 - 37 Show 3D Structure View in InterPro
R 23 - 37 Show 3D Structure View in InterPro
4E41 C 23 - 37 Show 3D Structure View in InterPro
H 23 - 37 Show 3D Structure View in InterPro
7 - 246 2VOM D 6 - 245 Show 3D Structure View in InterPro
4UNK B 6 - 245 Show 3D Structure View in InterPro
7 - 247 4UNK A 6 - 246 Show 3D Structure View in InterPro
7 - 248 1HTI A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
1WYI A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
2JK2 A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
2VOM A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
C 6 - 247 Show 3D Structure View in InterPro
4BR1 A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
4POC A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
4POD A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
4UNL A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
4ZVJ A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
6C2G A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
C 6 - 247 Show 3D Structure View in InterPro
D 6 - 247 Show 3D Structure View in InterPro
6D43 A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
6NLH A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
C 6 - 247 Show 3D Structure View in InterPro
D 6 - 247 Show 3D Structure View in InterPro
E 6 - 247 Show 3D Structure View in InterPro
F 6 - 247 Show 3D Structure View in InterPro
G 6 - 247 Show 3D Structure View in InterPro
H 6 - 247 Show 3D Structure View in InterPro
6UP1 A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
6UP5 A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
6UP8 A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
6UPF A 6 - 247 Show 3D Structure View in InterPro
B 6 - 247 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;