Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
21  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL2_HUMAN (P60568)

Summary

This is the summary of UniProt entry IL2_HUMAN (P60568).

Description: Interleukin-2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 153 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 25
Pfam IL2 7 150
low_complexity n/a 30 44
coiled_coil n/a 76 96
low_complexity n/a 78 91

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P60568. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
50
51
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
100
101
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS
150
151
TLT                                                   
153
 

Show the unformatted sequence.

Checksums:
CRC64:59E2F40F25860F84
MD5:bf1bb5889261195a99fed3be77c9da53

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IL2 21 - 150 1IRL A 1 - 130 Jmol OpenAstexViewer
23 - 150 2ERJ D 3 - 130 Jmol OpenAstexViewer
H 3 - 130 Jmol OpenAstexViewer
24 - 150 1M48 A 4 - 130 Jmol OpenAstexViewer
B 4 - 130 Jmol OpenAstexViewer
1M49 A 4 - 130 Jmol OpenAstexViewer
B 4 - 130 Jmol OpenAstexViewer
1QVN A 4 - 130 Jmol OpenAstexViewer
B 4 - 130 Jmol OpenAstexViewer
C 4 - 130 Jmol OpenAstexViewer
D 4 - 130 Jmol OpenAstexViewer
4NEJ A 4 - 130 Jmol OpenAstexViewer
5M5E D 4 - 130 Jmol OpenAstexViewer
25 - 150 1M4B A 5 - 130 Jmol OpenAstexViewer
1PW6 B 5 - 130 Jmol OpenAstexViewer
26 - 150 1M47 A 6 - 130 Jmol OpenAstexViewer
1M4C A 6 - 130 Jmol OpenAstexViewer
B 6 - 130 Jmol OpenAstexViewer
1NBP A 6 - 130 Jmol OpenAstexViewer
1PW6 A 6 - 130 Jmol OpenAstexViewer
1PY2 A 6 - 130 Jmol OpenAstexViewer
B 6 - 130 Jmol OpenAstexViewer
D 6 - 130 Jmol OpenAstexViewer
1Z92 A 6 - 130 Jmol OpenAstexViewer
2B5I A 6 - 130 Jmol OpenAstexViewer
3INK C 6 - 130 Jmol OpenAstexViewer
D 6 - 130 Jmol OpenAstexViewer
3QAZ A 6 - 130 Jmol OpenAstexViewer
b 6 - 130 Jmol OpenAstexViewer
D 6 - 130 Jmol OpenAstexViewer
e 6 - 130 Jmol OpenAstexViewer
G 6 - 130 Jmol OpenAstexViewer
h 6 - 130 Jmol OpenAstexViewer
J 6 - 130 Jmol OpenAstexViewer
M 6 - 130 Jmol OpenAstexViewer
P 6 - 130 Jmol OpenAstexViewer
S 6 - 130 Jmol OpenAstexViewer
V 6 - 130 Jmol OpenAstexViewer
Y 6 - 130 Jmol OpenAstexViewer
3QB1 A 6 - 130 Jmol OpenAstexViewer
B 6 - 130 Jmol OpenAstexViewer
C 6 - 130 Jmol OpenAstexViewer
D 6 - 130 Jmol OpenAstexViewer
E 6 - 130 Jmol OpenAstexViewer
F 6 - 130 Jmol OpenAstexViewer
G 6 - 130 Jmol OpenAstexViewer
H 6 - 130 Jmol OpenAstexViewer
4NEM A 6 - 130 Jmol OpenAstexViewer
5LQB A 26 - 150 Jmol OpenAstexViewer
27 - 150 1M4A A 7 - 130 Jmol OpenAstexViewer
1PY2 C 7 - 130 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.