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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SRP54_HUMAN (P61011)

Summary

This is the summary of UniProt entry SRP54_HUMAN (P61011).

Description: Signal recognition particle 54 kDa protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 504 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam SRP54_N 6 83
Pfam SRP54 101 296
Pfam SRP_SPB 326 431
disorder n/a 389 395
disorder n/a 398 400
disorder n/a 404 410
disorder n/a 449 459
disorder n/a 461 464
low_complexity n/a 489 503

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P61011. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVLADLGRKI TSALRSLSNA TIINEEVLNA MLKEVCTALL EADVNIKLVK
50
51
QLRENVKSAI DLEEMASGLN KRKMIQHAVF KELVKLVDPG VKAWTPTKGK
100
101
QNVIMFVGLQ GSGKTTTCSK LAYYYQRKGW KTCLICADTF RAGAFDQLKQ
150
151
NATKARIPFY GSYTEMDPVI IASEGVEKFK NENFEIIIVD TSGRHKQEDS
200
201
LFEEMLQVAN AIQPDNIVYV MDASIGQACE AQAKAFKDKV DVASVIVTKL
250
251
DGHAKGGGAL SAVAATKSPI IFIGTGEHID DFEPFKTQPF ISKLLGMGDI
300
301
EGLIDKVNEL KLDDNEALIE KLKHGQFTLR DMYEQFQNIM KMGPFSQILG
350
351
MIPGFGTDFM SKGNEQESMA RLKKLMTIMD SMNDQELDST DGAKVFSKQP
400
401
GRIQRVARGS GVSTRDVQEL LTQYTKFAQM VKKMGGIKGL FKGGDMSKNV
450
451
SQSQMAKLNQ QMAKMMDPRV LHHMGGMAGL QSMMRQFQQG AAGNMKGMMG
500
501
FNNM                                                  
504
 

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Checksums:
CRC64:7D7630A43BC5EC2C
MD5:915711fe6a4ce15238895d59a6b001a6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SRP54 101 - 296 5L3Q A 101 - 296 Jmol OpenAstexViewer
C 101 - 296 Jmol OpenAstexViewer
SRP54_N 24 - 83 5L3Q A 24 - 83 Jmol OpenAstexViewer
C 24 - 83 Jmol OpenAstexViewer
SRP_SPB 326 - 431 1MFQ C 326 - 431 Jmol OpenAstexViewer
1QB2 A 326 - 431 Jmol OpenAstexViewer
B 326 - 431 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.