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22  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RPAB2_HUMAN (P61218)

Summary

This is the summary of UniProt entry RPAB2_HUMAN (P61218).

Description: DNA-directed RNA polymerases I, II, and III subunit RPABC2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 127 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 54
low_complexity n/a 3 32
low_complexity n/a 26 37
Pfam RNA_pol_Rpb6 51 104

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P61218. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDNEDNFDG DDFDDVEEDE GLDDLENAEE EGQENVEILP SGERPQANQK
50
51
RITTPYMTKY ERARVLGTRA LQIAMCAPVM VELEGETDPL LIAMKELKAR
100
101
KIPIIIRRYL PDGSYEDWGV DELIITD                         
127
 

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Checksums:
CRC64:6362B0D7EB3F0921
MD5:0c903aed0cda8b46ab79c351155a511c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RNA_pol_Rpb6 51 - 104 1QKL A 851 - 904 Show 3D Structure View in InterPro
5IY6 F 51 - 104 Show 3D Structure View in InterPro
5IY7 F 51 - 104 Show 3D Structure View in InterPro
5IY8 F 51 - 104 Show 3D Structure View in InterPro
5IY9 F 51 - 104 Show 3D Structure View in InterPro
5IYA F 51 - 104 Show 3D Structure View in InterPro
5IYB F 51 - 104 Show 3D Structure View in InterPro
5IYC F 51 - 104 Show 3D Structure View in InterPro
5IYD F 51 - 104 Show 3D Structure View in InterPro
6DRD F 51 - 104 Show 3D Structure View in InterPro
6O9L F 51 - 104 Show 3D Structure View in InterPro
6XRE F 51 - 104 Show 3D Structure View in InterPro
7A6H F 51 - 104 Show 3D Structure View in InterPro
7AE1 F 51 - 104 Show 3D Structure View in InterPro
7AE3 F 51 - 104 Show 3D Structure View in InterPro
7AEA F 51 - 104 Show 3D Structure View in InterPro
7AST E 51 - 104 Show 3D Structure View in InterPro
7D58 F 51 - 104 Show 3D Structure View in InterPro
7D59 F 51 - 104 Show 3D Structure View in InterPro
7DN3 F 51 - 104 Show 3D Structure View in InterPro
7DU2 F 51 - 104 Show 3D Structure View in InterPro
7LBM F 51 - 104 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;