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22  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PRS4_HUMAN (P62191)

Summary

This is the summary of UniProt entry PRS4_HUMAN (P62191).

Description: 26S proteasome regulatory subunit 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 440 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 51
low_complexity n/a 6 23
low_complexity n/a 26 42
disorder n/a 82 104
disorder n/a 108 110
Pfam Prot_ATP_ID_OB 109 163
Pfam AAA 222 355
disorder n/a 295 298
disorder n/a 300 301
Pfam AAA_lid_3 377 421
disorder n/a 424 426

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62191. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP
50
51
LVTPHTQCRL KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD
100
101
DLRGTPMSVG TLEEIIDDNH AIVSTSVGSE HYVSILSFVD KDLLEPGCSV
150
151
LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP QETYADIGGL DNQIQEIKES
200
201
VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA NQTSATFLRV
250
251
VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG
300
301
GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK
350
351
IEFPLPDEKT KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT
400
401
EAGLMALRER RMKVTNEDFK KSKENVLYKK QEGTPEGLYL           
440
 

Show the unformatted sequence.

Checksums:
CRC64:ACA80782F4F96F49
MD5:906946e0e0e37df6f1457f5ea101b03c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AAA 222 - 355 5GJQ I 222 - 355 Jmol OpenAstexViewer
5GJR I 222 - 355 Jmol OpenAstexViewer
w 222 - 355 Jmol OpenAstexViewer
5L4G I 222 - 355 Jmol OpenAstexViewer
5LN3 I 222 - 355 Jmol OpenAstexViewer
5M32 d 222 - 355 Jmol OpenAstexViewer
5T0C AB 222 - 355 Jmol OpenAstexViewer
BB 222 - 355 Jmol OpenAstexViewer
5T0G B 222 - 355 Jmol OpenAstexViewer
5T0H B 222 - 355 Jmol OpenAstexViewer
5T0I B 222 - 355 Jmol OpenAstexViewer
5T0J B 222 - 355 Jmol OpenAstexViewer
5VHF B 222 - 355 Jmol OpenAstexViewer
5VHH B 222 - 355 Jmol OpenAstexViewer
5VHI B 222 - 355 Jmol OpenAstexViewer
5VHJ B 222 - 355 Jmol OpenAstexViewer
5VHM B 222 - 355 Jmol OpenAstexViewer
5VHN B 222 - 355 Jmol OpenAstexViewer
5VHO B 222 - 355 Jmol OpenAstexViewer
5VHP B 222 - 355 Jmol OpenAstexViewer
5VHQ B 222 - 355 Jmol OpenAstexViewer
5VHR B 222 - 355 Jmol OpenAstexViewer
5VHS B 222 - 355 Jmol OpenAstexViewer
AAA_lid_3 377 - 410 5VHJ B 377 - 410 Jmol OpenAstexViewer
377 - 421 5GJQ I 377 - 421 Jmol OpenAstexViewer
5GJR I 377 - 421 Jmol OpenAstexViewer
w 377 - 421 Jmol OpenAstexViewer
5L4G I 377 - 421 Jmol OpenAstexViewer
5LN3 I 377 - 421 Jmol OpenAstexViewer
5M32 d 377 - 421 Jmol OpenAstexViewer
5T0C AB 377 - 421 Jmol OpenAstexViewer
BB 377 - 421 Jmol OpenAstexViewer
5T0G B 377 - 421 Jmol OpenAstexViewer
5T0H B 377 - 421 Jmol OpenAstexViewer
5T0I B 377 - 421 Jmol OpenAstexViewer
5T0J B 377 - 421 Jmol OpenAstexViewer
5VHF B 377 - 421 Jmol OpenAstexViewer
5VHH B 377 - 421 Jmol OpenAstexViewer
5VHI B 377 - 421 Jmol OpenAstexViewer
5VHM B 377 - 421 Jmol OpenAstexViewer
5VHN B 377 - 421 Jmol OpenAstexViewer
5VHO B 377 - 421 Jmol OpenAstexViewer
5VHQ B 377 - 421 Jmol OpenAstexViewer
5VHR B 377 - 421 Jmol OpenAstexViewer
5VHS B 377 - 421 Jmol OpenAstexViewer
379 - 421 5VHP B 379 - 421 Jmol OpenAstexViewer
Prot_ATP_ID_OB 109 - 163 5GJQ I 109 - 163 Jmol OpenAstexViewer
5GJR I 109 - 163 Jmol OpenAstexViewer
w 109 - 163 Jmol OpenAstexViewer
5L4G I 109 - 163 Jmol OpenAstexViewer
5LN3 I 109 - 163 Jmol OpenAstexViewer
5M32 d 109 - 163 Jmol OpenAstexViewer
5T0C AB 109 - 163 Jmol OpenAstexViewer
BB 109 - 163 Jmol OpenAstexViewer
5T0G B 109 - 163 Jmol OpenAstexViewer
5T0H B 109 - 163 Jmol OpenAstexViewer
5T0I B 109 - 163 Jmol OpenAstexViewer
5T0J B 109 - 163 Jmol OpenAstexViewer
5VGZ B 109 - 163 Jmol OpenAstexViewer
5VHF B 109 - 163 Jmol OpenAstexViewer
5VHH B 109 - 163 Jmol OpenAstexViewer
5VHI B 109 - 163 Jmol OpenAstexViewer
5VHS B 109 - 163 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.