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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: 1433E_HUMAN (P62258)

Summary

This is the summary of UniProt entry 1433E_HUMAN (P62258).

Description: 14-3-3 protein epsilon
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 255 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam 14-3-3 10 232
disorder n/a 234 255

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62258. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK
50
51
NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI
100
101
LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV
150
151
AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD
200
201
DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV
250
251
EDENQ                                                 
255
 

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Checksums:
CRC64:07817CCBD1F75B26
MD5:76c3a409540532138c6b44bde9e4d248

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
14-3-3 10 - 232 2BR9 A 10 - 232 Jmol OpenAstexViewer
3UAL A 10 - 232 Jmol OpenAstexViewer
3UBW A 10 - 232 Jmol OpenAstexViewer
6EIH A 10 - 232 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.