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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RPB7_HUMAN (P62487)

Summary

This is the summary of UniProt entry RPB7_HUMAN (P62487).

Description: DNA-directed RNA polymerase II subunit RPB7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 172 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam SHS2_Rpb7-N 8 77
Pfam S1 78 161
disorder n/a 122 124
disorder n/a 130 131
low_complexity n/a 131 142

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62487. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT
50
51
IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE
100
101
IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT
150
151
RVDKNDIFAI GSLMDDYLGL VS                              
172
 

Show the unformatted sequence.

Checksums:
CRC64:AF3CE655F658CD5C
MD5:91983f2babc4bf7eb49eae56eb6fa863

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
S1 78 - 161 2C35 B 78 - 161 Jmol OpenAstexViewer
D 78 - 161 Jmol OpenAstexViewer
F 78 - 161 Jmol OpenAstexViewer
H 78 - 161 Jmol OpenAstexViewer
5IY6 G 78 - 161 Jmol OpenAstexViewer
5IY7 G 78 - 161 Jmol OpenAstexViewer
5IY8 G 78 - 161 Jmol OpenAstexViewer
5IY9 G 78 - 161 Jmol OpenAstexViewer
5IYA G 78 - 161 Jmol OpenAstexViewer
5IYB G 78 - 161 Jmol OpenAstexViewer
5IYC G 78 - 161 Jmol OpenAstexViewer
5IYD G 78 - 161 Jmol OpenAstexViewer
SHS2_Rpb7-N 8 - 77 2C35 B 8 - 77 Jmol OpenAstexViewer
D 8 - 77 Jmol OpenAstexViewer
F 8 - 77 Jmol OpenAstexViewer
H 8 - 77 Jmol OpenAstexViewer
5IY6 G 8 - 77 Jmol OpenAstexViewer
5IY7 G 8 - 77 Jmol OpenAstexViewer
5IY8 G 8 - 77 Jmol OpenAstexViewer
5IY9 G 8 - 77 Jmol OpenAstexViewer
5IYA G 8 - 77 Jmol OpenAstexViewer
5IYB G 8 - 77 Jmol OpenAstexViewer
5IYC G 8 - 77 Jmol OpenAstexViewer
5IYD G 8 - 77 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.