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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RPB7_HUMAN (P62487)

Summary

This is the summary of UniProt entry RPB7_HUMAN (P62487).

Description: DNA-directed RNA polymerase II subunit RPB7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 172 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam SHS2_Rpb7-N 8 64
Pfam S1 78 161
disorder n/a 122 124
disorder n/a 130 131
low_complexity n/a 132 143

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62487. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT
50
51
IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE
100
101
IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT
150
151
RVDKNDIFAI GSLMDDYLGL VS                              
172
 

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Checksums:
CRC64:AF3CE655F658CD5C
MD5:91983f2babc4bf7eb49eae56eb6fa863

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
S1 78 - 161 2C35 B 78 - 161 Show 3D Structure View in InterPro
D 78 - 161 Show 3D Structure View in InterPro
F 78 - 161 Show 3D Structure View in InterPro
H 78 - 161 Show 3D Structure View in InterPro
5IY6 G 78 - 161 Show 3D Structure View in InterPro
5IY7 G 78 - 161 Show 3D Structure View in InterPro
5IY8 G 78 - 161 Show 3D Structure View in InterPro
5IY9 G 78 - 161 Show 3D Structure View in InterPro
5IYA G 78 - 161 Show 3D Structure View in InterPro
5IYB G 78 - 161 Show 3D Structure View in InterPro
5IYC G 78 - 161 Show 3D Structure View in InterPro
5IYD G 78 - 161 Show 3D Structure View in InterPro
6DRD G 78 - 161 Show 3D Structure View in InterPro
6O9L G 78 - 161 Show 3D Structure View in InterPro
6XRE G 78 - 161 Show 3D Structure View in InterPro
7LBM G 78 - 161 Show 3D Structure View in InterPro
SHS2_Rpb7-N 8 - 64 2C35 B 8 - 64 Show 3D Structure View in InterPro
D 8 - 64 Show 3D Structure View in InterPro
F 8 - 64 Show 3D Structure View in InterPro
H 8 - 64 Show 3D Structure View in InterPro
5IY6 G 8 - 64 Show 3D Structure View in InterPro
5IY7 G 8 - 64 Show 3D Structure View in InterPro
5IY8 G 8 - 64 Show 3D Structure View in InterPro
5IY9 G 8 - 64 Show 3D Structure View in InterPro
5IYA G 8 - 64 Show 3D Structure View in InterPro
5IYB G 8 - 64 Show 3D Structure View in InterPro
5IYC G 8 - 64 Show 3D Structure View in InterPro
5IYD G 8 - 64 Show 3D Structure View in InterPro
6DRD G 8 - 64 Show 3D Structure View in InterPro
6O9L G 8 - 64 Show 3D Structure View in InterPro
6XRE G 8 - 64 Show 3D Structure View in InterPro
7LBM G 8 - 64 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;