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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NANA_STRR6 (P62576)

Summary

This is the summary of UniProt entry NANA_STRR6 (P62576).

Description: Sialidase A EC=3.2.1.18
Source organism: Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (NCBI taxonomy ID 171101)
Length: 1035 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 4 17
Pfam YSIRK_signal 22 47
transmembrane n/a 32 53
disorder n/a 52 110
low_complexity n/a 93 105
Pfam Sialidase 118 309
disorder n/a 121 144
low_complexity n/a 138 150
disorder n/a 150 152
disorder n/a 154 155
disorder n/a 199 201
disorder n/a 206 208
disorder n/a 226 227
disorder n/a 303 305
disorder n/a 307 310
disorder n/a 324 336
disorder n/a 341 345
disorder n/a 391 408
disorder n/a 411 417
disorder n/a 476 479
disorder n/a 601 603
Pfam BNR 607 618
disorder n/a 618 649
disorder n/a 712 714
disorder n/a 723 727
disorder n/a 799 800
disorder n/a 859 867
disorder n/a 874 982
disorder n/a 988 991
disorder n/a 994 1011
transmembrane n/a 1013 1030
low_complexity n/a 1013 1030

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P62576. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSYFRNRDID IERNSMNRSV QERKCRYSIR KLSVGAVSMI VGAVVFGTSP
50
51
VLAQEGASEQ PLANETQLSG ESSTLTDTEK SQPSSETELS GNKQEQERKD
100
101
KQEEKIPRDY YARDLENVET VIEKEDVETN ASNGQRVDLS SELDKLKKLE
150
151
NATVHMEFKP DAKAPAFYNL FSVSSATKKD EYFTMAVYNN TATLEGRGSD
200
201
GKQFYNNYND APLKVKPGQW NSVTFTVEKP TAELPKGRVR LYVNGVLSRT
250
251
SLRSGNFIKD MPDVTHVQIG ATKRANNTVW GSNLQIRNLT VYNRALTPEE
300
301
VQKRSQLFKR SDLEKKLPEG AALTEKTDIF ESGRNGKPNK DGIKSYRIPA
350
351
LLKTDKGTLI AGADERRLHS SDWGDIGMVI RRSEDNGKTW GDRVTITNLR
400
401
DNPKASDPSI GSPVNIDMVL VQDPETKRIF SIYDMFPEGK GIFGMSSQKE
450
451
EAYKKIDGKT YQILYREGEK GAYTIRENGT VYTPDGKATD YRVVVDPVKP
500
501
AYSDKGDLYK GNQLLGNIYF TTNKTSPFRI AKDSYLWMSY SDDDGKTWSA
550
551
PQDITPMVKA DWMKFLGVGP GTGIVLRNGP HKGRILIPVY TTNNVSHLNG
600
601
SQSSRIIYSD DHGKTWHAGE AVNDNRQVDG QKIHSSTMNN RRAQNTESTV
650
651
VQLNNGDVKL FMRGLTGDLQ VATSKDGGVT WEKDIKRYPQ VKDVYVQMSA
700
701
IHTMHEGKEY IILSNAGGPK RENGMVHLAR VEENGELTWL KHNPIQKGEF
750
751
AYNSLQELGN GEYGILYEHT EKGQNAYTLS FRKFNWDFLS KDLISPTEAK
800
801
VKRTREMGKG VIGLEFDSEV LVNKAPTLQL ANGKTARFMT QYDTKTLLFT
850
851
VDSEDMGQKV TGLAEGAIES MHNLPVSVAG TKLSNGMNGS EAAVHEVPEY
900
901
TGPLGTSGEE PAPTVEKPEY TGPLGTSGEE PAPTVEKPEY TGPLGTAGEE
950
951
AAPTVEKPEF TGGVNGTEPA VHEIAEYKGS DSLVTLTTKE DYTYKAPLAQ
1000
1001
QALPETGNKE SDLLASLGLT AFFLGLFTLG KKREQ                
1035
 

Show the unformatted sequence.

Checksums:
CRC64:C5B8A2D7A12E12F3
MD5:10866d349b6fca837fe416f0101f863b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BNR 607 - 618 2W20 A 607 - 618 Show 3D Structure View in InterPro
B 607 - 618 Show 3D Structure View in InterPro
3H71 A 607 - 618 Show 3D Structure View in InterPro
B 607 - 618 Show 3D Structure View in InterPro
3H72 A 607 - 618 Show 3D Structure View in InterPro
B 607 - 618 Show 3D Structure View in InterPro
3H73 A 607 - 618 Show 3D Structure View in InterPro
B 607 - 618 Show 3D Structure View in InterPro
6QZH A 1286 - 1297 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;