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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AP2B1_HUMAN (P63010)

Summary

This is the summary of UniProt entry AP2B1_HUMAN (P63010).

Description: AP-2 complex subunit beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 937 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Adaptin_N 10 534
low_complexity n/a 16 36
disorder n/a 505 507
disorder n/a 585 587
disorder n/a 592 620
low_complexity n/a 624 642
low_complexity n/a 652 664
disorder n/a 680 681
Pfam Alpha_adaptinC2 711 817
Pfam B2-adapt-app_C 827 935

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P63010. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL
50
51
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP
100
101
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD
150
151
INAQMVEDQG FLDSLRDLIA DSNPMVVANA VAALSEISES HPNSNLLDLN
200
201
PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI CERVTPRLSH
250
251
ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY
300
301
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN
350
351
IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ
400
401
TKVNYVVQEA IVVIRDIFRK YPNKYESIIA TLCENLDSLD EPDARAAMIW
450
451
IVGEYAERID NADELLESFL EGFHDESTQV QLTLLTAIVK LFLKKPSETQ
500
501
ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV VLSEKPLISE
550
551
ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
600
601
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM
650
651
GAVDLLGGGL DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI
700
701
GMAPGGYVAP KAVWLPAVKA KGLEISGTFT HRQGHIYMEM NFTNKALQHM
750
751
TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ SIDVSLPLNT LGPVMKMEPL
800
801
NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT WKDIPNENEL
850
851
QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL
900
901
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN              
937
 

Show the unformatted sequence.

Checksums:
CRC64:B472EE5B2AE176DF
MD5:45520c9bf36d261c4311fcaf0ae9bd89

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Adaptin_N 10 - 534 2VGL B 10 - 534 Jmol OpenAstexViewer
2XA7 B 10 - 534 Jmol OpenAstexViewer
4UQI B 10 - 534 Jmol OpenAstexViewer
12 - 534 2JKR B 12 - 534 Jmol OpenAstexViewer
E 12 - 534 Jmol OpenAstexViewer
2JKT B 12 - 534 Jmol OpenAstexViewer
E 12 - 534 Jmol OpenAstexViewer
Alpha_adaptinC2 711 - 817 1E42 A 711 - 817 Jmol OpenAstexViewer
B 711 - 817 Jmol OpenAstexViewer
2G30 A 711 - 817 Jmol OpenAstexViewer
2IV8 A 711 - 817 Jmol OpenAstexViewer
2IV9 A 711 - 817 Jmol OpenAstexViewer
B 711 - 817 Jmol OpenAstexViewer
B2-adapt-app_C 827 - 935 1E42 A 827 - 935 Jmol OpenAstexViewer
B 827 - 935 Jmol OpenAstexViewer
2G30 A 827 - 935 Jmol OpenAstexViewer
2IV8 A 827 - 935 Jmol OpenAstexViewer
2IV9 A 827 - 935 Jmol OpenAstexViewer
B 827 - 935 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.