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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: POK7_HUMAN (P63135)

Summary

This is the summary of UniProt entry POK7_HUMAN (P63135).

Description: Endogenous retrovirus group K member 7 Pol protein Reverse transcriptase Ribonuclease H Integrase EC=2.7.7.49 EC=3.1.26.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1459 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 9 12
Pfam RVT_1 76 245
low_complexity n/a 244 259
Pfam RVT_thumb 252 317
Pfam RNase_H 461 590
low_complexity n/a 540 550
Pfam Integrase_Zn 592 629
Pfam rve 644 739
disorder n/a 755 761
disorder n/a 763 765
disorder n/a 795 803
Pfam IN_DBD_C 813 857
Pfam HERV-K_env_2 875 1043
disorder n/a 985 989
disorder n/a 1046 1047
disorder n/a 1053 1055
disorder n/a 1084 1088
transmembrane n/a 1226 1251
low_complexity n/a 1239 1250
Pfam GP41 1246 1442
coiled_coil n/a 1336 1356
transmembrane n/a 1393 1415
low_complexity n/a 1398 1417

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P63135. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
NKSRKRRNRL SFLGAATVEP PKPIPLTWKT EKPVWVNQWP LPKQKLEALH
50
51
LLANEQLEKG HIEPSFSPWN SPVFVIQKKS GKWRMLTDLR AVNAVIQPMG
100
101
PLQPGLPSPA MIPKDWPLII IDLKDCFFTI PLAEQDCEKF AFTIPAINNK
150
151
EPATRFQWKV LPQGMLNSPT ICQTFVGRAL QPVREKFSDC YIIHYIDDIL
200
201
CAAETRDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY LGMQIENRKI
250
251
KQQKIEIRKD TLKTLNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
300
301
DLNSKRILTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG
350
351
IIIQNTDLVE WSFLPHSTVK TFTLYLDQIA TLIGQTRLRI IKLCGNDPDK
400
401
IVVPLTKEQV RQAFINSGAW QIGLANFVGI IDNHYPKTKI FQFLKLTTWI
450
451
LPKITRREPL ENALTVFTDG SSNGKAAYTG PKERVIKTPY QSAQRAELVA
500
501
VITVLQDFDQ PINIISDSAY VVQATRDVET ALIKYSMDDQ LNQLFNLLQQ
550
551
TVRKRNFPFY ITHIRAHTNL PGPLTKANEQ ADLLVSSALI KAQELHALTH
600
601
VNAAGLKNKF DVTWKQAKDI VQHCTQCQIL HLPTQEAGVN PRGLCPNALW
650
651
QMDVTHVPSF GRLSYVHVTV DTYSHFIWAT CQTGESTSHV KKHLLSCFAV
700
701
MGVPEKIKTD NGPGYCSKAF QKFLSQWKIS HTTGIPYNSQ GQAIVERTNR
750
751
TLKTQLVKQK EGGDSKECTT PQMQLNLALY TLNFLNIYRN QTTTSAEQHL
800
801
TGKKNSPHEG KLIWWKDNKN KTWEIGKVIT WGRGFACVSP GENQLPVWIP
850
851
TRHLKFYNEP IGDAKKRAST EMVTPVTWMD NPIEIYVNDS VWVPGPIDDR
900
901
CPAKPEEEGM MINISIGYRY PPICLGRAPG CLMPAVQNWL VEVPTVSPIS
950
951
RFTYHMVSGM SLRPRVNYLQ DFSYQRSLKF RPKGKPCPKE IPKESKNTEV
1000
1001
LVWEECVANS AVILQNNEFG TIIDWAPRGQ FYHNCSGQTQ SCPSAQVSPA
1050
1051
VDSDLTESLD KHKHKKLQSF YPWEWGEKGI STPRPKIVSP VSGPEHPELW
1100
1101
RLTVASHHIR IWSGNQTLET RDCKPFYTID LNSSLTVPLQ SCVKPPYMLV
1150
1151
VGNIVIKPDS QTITCENCRL LTCIDSTFNW QHRILLVRAR EGVWIPVSMD
1200
1201
RPWEASPSVH ILTEVLKGVL NRSKRFIFTL IAVIMGLIAV TATAAVAGVA
1250
1251
LHSSVQSVNF VNDWQKNSTR LWNSQSSIDQ KLANQINDLR QTVIWMGDRL
1300
1301
MSLEHRFQLQ CDWNTSDFCI TPQIYNESEH HWDMVRRHLQ GREDNLTLDI
1350
1351
SKLKEQIFEA SKAHLNLVPG TEAIAGVADG LANLNPVTWV KTIGSTTIIN
1400
1401
LILILVCLFC LLLVCRCTQQ LRRDSDHRER AMMTMAVLSK RKGGNVGKSK
1450
1451
RDQIVTVSV                                             
1459
 

Show the unformatted sequence.

Checksums:
CRC64:6EC79CA4D54BFBFD
MD5:88eb166b4a4cf123ca93e3cc104c8bea

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;