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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: POK25_HUMAN (P63136)

Summary

This is the summary of UniProt entry POK25_HUMAN (P63136).

Description: Endogenous retrovirus group K member 25 Pol protein Reverse transcriptase Ribonuclease H Integrase EC=2.7.7.49 EC=3.1.26.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 954 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 3 6
disorder n/a 9 14
Pfam RVT_1 76 245
Pfam RVT_thumb 252 317
Pfam RNase_H 461 588
low_complexity n/a 538 548
Pfam Integrase_Zn 590 627
Pfam rve 642 737
disorder n/a 753 759
disorder n/a 761 763
disorder n/a 793 801
disorder n/a 805 809
Pfam IN_DBD_C 811 855
disorder n/a 858 922

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P63136. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
NKSKKRRNRV SFLGAATVEP PKPIPLTWKT EKPVWVNQWP LPKQKLEALH
50
51
LLANEQLEKG HIEPSFSPWN SPVFVIQKKS GKWRMLTDLR AVNAVIQPMG
100
101
PLQPGLPSPA MIPKDWPLII IDLKDCFFTI PLAEQDCEKF AFTIPAINNK
150
151
EPATRFQWKV LPQGMLNSPT ICQTFVGRAL QPVREKFSDC YIIHYIDDIL
200
201
CAAETKDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY LGMQIENRKI
250
251
KPQKIEIRKD TLKALNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
300
301
DLNSKRMLTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG
350
351
IIIQNTDLVE WSFLPHSTVK TFTLYLDQIA TLIGQTRLRI IKLCGNDPDK
400
401
IVVPLTKEQV RQAFINSGAW QIGLANFVGI IDNHYPKTKI FQFLKLTTWI
450
451
LPKITRREPL ENALTVFTDG SSNGKAAYTG PKERVIKTPY QSAQRAELVA
500
501
VITVLQDFDI NIISDSAYVV QATRDVETAL IKYSMDDQLN QLFNLLQQTV
550
551
RKRNFPFYIT HIRAHTNLPG PLTKANKQAD LLVSSALIKA QELHALTHVN
600
601
AAGLKNKFDV TWKLAKDIVQ HCTQCQVLHL PTQEAGVNPR GLCPNALWQM
650
651
DVTHVPSFGR LSYVHVTVDT YSHFIWATCH TGESTSHVKK HLLSCFAVMG
700
701
VPEKIKTDNG PGYCSKAFQK FLSQWKISHT TGIPYNSQGQ AIVERTNRTL
750
751
KTQLVKQKEG GDSKECTTPQ MQLNLALYTL NFLNIYRNQT TTSAEQHLTG
800
801
KKNSPHEGKL IWWKDNKNKT WEIGKVITWG RGFACVSPGE NQLPVWIPTR
850
851
HLKFYNEPIR DAKKSTSAET ETPQSSTVDS QDEQNGDVRR TDEVAIHQEG
900
901
RAANLGTTKE ADAVSYKISR EHKGDTNPRE YAACSLDDCI NGGKSPYACR
950
951
SSCS                                                  
954
 

Show the unformatted sequence.

Checksums:
CRC64:545C6BCD401CB4C1
MD5:b0bd55070117ac9ef1c6d068db4d8515

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;