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36  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SKP1_HUMAN (P63208)

Summary

This is the summary of UniProt entry SKP1_HUMAN (P63208).

Description: S-phase kinase-associated protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 163 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
Pfam Skp1_POZ 2 67
low_complexity n/a 30 43
disorder n/a 31 47
disorder n/a 63 83
low_complexity n/a 66 80
Pfam Skp1 113 160
disorder n/a 138 142
disorder n/a 146 147
disorder n/a 152 159

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P63208. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV
50
51
NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL
100
101
FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE
150
151
AQVRKENQWC EEK                                        
163
 

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Checksums:
CRC64:C794D62AFB75528A
MD5:caa4380b0beae658ce5d091b8debd603

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Skp1 113 - 140 1FS1 B 113 - 140 Show 3D Structure View in InterPro
D 113 - 140 Show 3D Structure View in InterPro
1LDK D 2113 - 2140 Show 3D Structure View in InterPro
113 - 144 6BYH G 113 - 144 Show 3D Structure View in InterPro
113 - 146 1FS2 B 113 - 146 Show 3D Structure View in InterPro
D 113 - 146 Show 3D Structure View in InterPro
113 - 154 2E32 B 113 - 154 Show 3D Structure View in InterPro
D 113 - 154 Show 3D Structure View in InterPro
113 - 155 2E31 B 113 - 155 Show 3D Structure View in InterPro
6BYH A 113 - 155 Show 3D Structure View in InterPro
6C16 A 113 - 155 Show 3D Structure View in InterPro
113 - 156 5IBK A 113 - 156 Show 3D Structure View in InterPro
113 - 157 1P22 B 92 - 136 Show 3D Structure View in InterPro
6C16 B 113 - 157 Show 3D Structure View in InterPro
6M90 B 95 - 139 Show 3D Structure View in InterPro
6M91 B 95 - 139 Show 3D Structure View in InterPro
6M92 B 95 - 139 Show 3D Structure View in InterPro
6M93 B 95 - 139 Show 3D Structure View in InterPro
6M94 B 95 - 139 Show 3D Structure View in InterPro
6TTU S 95 - 139 Show 3D Structure View in InterPro
6WNX E 95 - 139 Show 3D Structure View in InterPro
113 - 159 2OVP A 1113 - 1159 Show 3D Structure View in InterPro
2OVQ A 1113 - 1159 Show 3D Structure View in InterPro
5JH5 B 113 - 159 Show 3D Structure View in InterPro
113 - 160 1FQV B 113 - 160 Show 3D Structure View in InterPro
D 113 - 160 Show 3D Structure View in InterPro
F 113 - 160 Show 3D Structure View in InterPro
H 113 - 160 Show 3D Structure View in InterPro
J 113 - 160 Show 3D Structure View in InterPro
L 113 - 160 Show 3D Structure View in InterPro
N 113 - 160 Show 3D Structure View in InterPro
P 113 - 160 Show 3D Structure View in InterPro
2ASS A 1113 - 1160 Show 3D Structure View in InterPro
2AST A 1113 - 1160 Show 3D Structure View in InterPro
2OVR A 1113 - 1160 Show 3D Structure View in InterPro
3L2O A 1113 - 1160 Show 3D Structure View in InterPro
3WSO B 113 - 160 Show 3D Structure View in InterPro
4I6J C 113 - 160 Show 3D Structure View in InterPro
5IBK D 113 - 160 Show 3D Structure View in InterPro
5K35 B 113 - 160 Show 3D Structure View in InterPro
5V4B A 1113 - 1160 Show 3D Structure View in InterPro
5VZT A 1113 - 1160 Show 3D Structure View in InterPro
C 1113 - 1160 Show 3D Structure View in InterPro
5VZU A 1113 - 1160 Show 3D Structure View in InterPro
C 1113 - 1160 Show 3D Structure View in InterPro
5XYL A 113 - 160 Show 3D Structure View in InterPro
6BVA C 113 - 160 Show 3D Structure View in InterPro
D 113 - 160 Show 3D Structure View in InterPro
6BYH B 113 - 160 Show 3D Structure View in InterPro
6O60 D 113 - 160 Show 3D Structure View in InterPro
6VCD C 113 - 160 Show 3D Structure View in InterPro
6W66 A 113 - 160 Show 3D Structure View in InterPro
6WCQ A 113 - 160 Show 3D Structure View in InterPro
6WNX B 95 - 142 Show 3D Structure View in InterPro
H 95 - 142 Show 3D Structure View in InterPro
Skp1_POZ 2 - 65 1P22 B 2 - 59 Show 3D Structure View in InterPro
2OVP A 1002 - 1065 Show 3D Structure View in InterPro
2OVQ A 1002 - 1065 Show 3D Structure View in InterPro
2OVR A 1002 - 1065 Show 3D Structure View in InterPro
2 - 66 6M90 B 2 - 60 Show 3D Structure View in InterPro
6M91 B 2 - 60 Show 3D Structure View in InterPro
6M92 B 2 - 60 Show 3D Structure View in InterPro
6M94 B 2 - 60 Show 3D Structure View in InterPro
6TTU S 2 - 60 Show 3D Structure View in InterPro
2 - 67 1FQV B 2 - 67 Show 3D Structure View in InterPro
D 2 - 67 Show 3D Structure View in InterPro
F 2 - 67 Show 3D Structure View in InterPro
H 2 - 67 Show 3D Structure View in InterPro
J 2 - 67 Show 3D Structure View in InterPro
L 2 - 67 Show 3D Structure View in InterPro
N 2 - 67 Show 3D Structure View in InterPro
P 2 - 67 Show 3D Structure View in InterPro
1FS1 B 2 - 67 Show 3D Structure View in InterPro
D 2 - 67 Show 3D Structure View in InterPro
1FS2 B 2 - 67 Show 3D Structure View in InterPro
D 2 - 67 Show 3D Structure View in InterPro
1LDK D 2002 - 2061 Show 3D Structure View in InterPro
2E31 B 2 - 67 Show 3D Structure View in InterPro
2E32 B 2 - 67 Show 3D Structure View in InterPro
D 2 - 67 Show 3D Structure View in InterPro
3L2O A 1002 - 1067 Show 3D Structure View in InterPro
3WSO B 2 - 67 Show 3D Structure View in InterPro
5IBK A 2 - 67 Show 3D Structure View in InterPro
D 2 - 67 Show 3D Structure View in InterPro
5JH5 B 2 - 67 Show 3D Structure View in InterPro
5K35 B 2 - 67 Show 3D Structure View in InterPro
5V4B A 1002 - 1067 Show 3D Structure View in InterPro
5VZT A 1002 - 1067 Show 3D Structure View in InterPro
C 1002 - 1067 Show 3D Structure View in InterPro
5VZU A 1002 - 1067 Show 3D Structure View in InterPro
C 1002 - 1067 Show 3D Structure View in InterPro
5XYL A 2 - 67 Show 3D Structure View in InterPro
6BVA C 2 - 67 Show 3D Structure View in InterPro
D 2 - 67 Show 3D Structure View in InterPro
6BYH A 2 - 67 Show 3D Structure View in InterPro
B 2 - 67 Show 3D Structure View in InterPro
G 2 - 67 Show 3D Structure View in InterPro
6C16 A 2 - 67 Show 3D Structure View in InterPro
B 2 - 67 Show 3D Structure View in InterPro
6O60 D 2 - 67 Show 3D Structure View in InterPro
6VCD C 2 - 67 Show 3D Structure View in InterPro
6W66 A 2 - 67 Show 3D Structure View in InterPro
6WCQ A 2 - 67 Show 3D Structure View in InterPro
6WNX B 2 - 61 Show 3D Structure View in InterPro
H 2 - 61 Show 3D Structure View in InterPro
3 - 64 4I6J C 3 - 64 Show 3D Structure View in InterPro
3 - 65 6M93 B 3 - 59 Show 3D Structure View in InterPro
3 - 67 2ASS A 1003 - 1061 Show 3D Structure View in InterPro
2AST A 1003 - 1061 Show 3D Structure View in InterPro
4 - 67 6WNX E 4 - 61 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;