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17  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PP2AA_HUMAN (P67775)

Summary

This is the summary of UniProt entry PP2AA_HUMAN (P67775).

Description: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 309 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Metallophos 50 245
disorder n/a 300 301

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P67775. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC
50
51
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
100
101
VALKVRYRER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
150
151
DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW
200
201
SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW
250
251
CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV
300
301
TRRTPDYFL                                             
309
 

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Checksums:
CRC64:C602291F78F34555
MD5:aa0b840e9aeb94125fd4fafcc85b5683

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Metallophos 50 - 245 2IAE C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
2IE3 C 50 - 245 Jmol OpenAstexViewer
2IE4 C 50 - 245 Jmol OpenAstexViewer
2NPP C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
2NYL C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
2NYM C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
3C5W C 50 - 245 Jmol OpenAstexViewer
3DW8 C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
3FGA C 50 - 245 Jmol OpenAstexViewer
3K7V C 50 - 245 Jmol OpenAstexViewer
3K7W C 50 - 245 Jmol OpenAstexViewer
3P71 C 50 - 245 Jmol OpenAstexViewer
4I5L C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
4I5N C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
4LAC C 50 - 245 Jmol OpenAstexViewer
5W0W C 50 - 245 Jmol OpenAstexViewer
F 50 - 245 Jmol OpenAstexViewer
I 50 - 245 Jmol OpenAstexViewer
L 50 - 245 Jmol OpenAstexViewer
55 - 153 4IYP C 55 - 153 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.