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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: YAHK_ECOLI (P75691)

Summary

This is the summary of UniProt entry YAHK_ECOLI (P75691).

Description: Aldehyde reductase YahK EC=1.1.1.2
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 349 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 16 24
Pfam ADH_N 27 143
disorder n/a 110 123
disorder n/a 125 127
low_complexity n/a 173 192
Pfam ADH_zinc_N 185 309
disorder n/a 215 220
disorder n/a 266 270

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P75691. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKIKAVGAYS AKQPLEPMDI TRREPGPNDV KIEIAYCGVC HSDLHQVRSE
50
51
WAGTVYPCVP GHEIVGRVVA VGDQVEKYAP GDLVGVGCIV DSCKHCEECE
100
101
DGLENYCDHM TGTYNSPTPD EPGHTLGGYS QQIVVHERYV LRIRHPQEQL
150
151
AAVAPLLCAG ITTYSPLRHW QAGPGKKVGV VGIGGLGHMG IKLAHAMGAH
200
201
VVAFTTSEAK REAAKALGAD EVVNSRNADE MAAHLKSFDF ILNTVAAPHN
250
251
LDDFTTLLKR DGTMTLVGAP ATPHKSPEVF NLIMKRRAIA GSMIGGIPET
300
301
QEMLDFCAEH GIVADIEMIR ADQINEAYER MLRGDVKYRF VIDNRTLTD 
349
 

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Checksums:
CRC64:AD0E2DF4D43C9B09
MD5:b5d80ba7a45d546018efaf0d15f43c1c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ADH_N 27 - 143 1UUF A 27 - 143 Show 3D Structure View in InterPro
ADH_zinc_N 185 - 309 1UUF A 185 - 309 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;