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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: JAG1_HUMAN (P78504)

Summary

This is the summary of UniProt entry JAG1_HUMAN (P78504).

Description: Protein jagged-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1218 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 7
sig_p n/a 1 30
low_complexity n/a 2 26
Pfam MNNL 32 107
disorder n/a 152 155
Pfam DSL 167 229
Pfam EGF 300 332
Pfam EGF 340 370
Pfam EGF 378 408
Pfam EGF_CA 412 450
Pfam EGF 450 483
Pfam EGF 491 521
Pfam EGF 529 559
Pfam EGF 633 663
Pfam EGF 671 701
Pfam EGF 748 777
Pfam EGF 786 816
Pfam hEGF 829 849
transmembrane n/a 1068 1093
disorder n/a 1100 1217

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P78504. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRSPRTRGRS GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ
50
51
NGNCCGGARN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP
100
101
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTVQPDS
150
151
IIEKASHSGM INPSRQWQTL KQNTGVAHFE YQIRVTCDDY YYGFGCNKFC
200
201
RPRDDFFGHY ACDQNGNKTC MEGWMGPECN RAICRQGCSP KHGSCKLPGD
250
251
CRCQYGWQGL YCDKCIPHPG CVHGICNEPW QCLCETNWGG QLCDKDLNYC
300
301
GTHQPCLNGG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS
350
351
CKETSLGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC
400
401
PPQWTGKTCQ LDANECEAKP CVNAKSCKNL IASYYCDCLP GWMGQNCDIN
450
451
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG
500
501
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK
550
551
CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG
600
601
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCRN GGTCIDGVNS
650
651
YKCICSDGWE GAYCETNIND CSQNPCHNGG TCRDLVNDFY CDCKNGWKGK
700
701
TCHSRDSQCD EATCNNGGTC YDEGDAFKCM CPGGWEGTTC NIARNSSCLP
750
751
NPCHNGGTCV VNGESFTCVC KEGWEGPICA QNTNDCSPHP CYNSGTCVDG
800
801
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYRCVCPPGH
850
851
SGAKCQEVSG RPCITMGSVI PDGAKWDDDC NTCQCLNGRI ACSKVWCGPR
900
901
PCLLHKGHSE CPSGQSCIPI LDDQCFVHPC TGVGECRSSS LQPVKTKCTS
950
951
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI
1000
1001
ACEPSPSANN EIHVAISAED IRDDGNPIKE ITDKIIDLVS KRDGNSSLIA
1050
1051
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WICCLVTAFY WCLRKRRKPG
1100
1101
SHTHSASEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR
1150
1151
THNSEVEEDD MDKHQQKARF AKQPAYTLVD REEKPPNGTP TKHPNWTNKQ
1200
1201
DNRDLESAQS LNRMEYIV                                   
1218
 

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Checksums:
CRC64:F36EE9FBF64DF162
MD5:84706f0ee2a4d23ae4050036e62dac5d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DSL 167 - 229 4CBZ A 167 - 229 Show 3D Structure View in InterPro
B 167 - 229 Show 3D Structure View in InterPro
4CC0 A 167 - 229 Show 3D Structure View in InterPro
B 167 - 229 Show 3D Structure View in InterPro
4CC1 A 167 - 229 Show 3D Structure View in InterPro
B 167 - 229 Show 3D Structure View in InterPro
186 - 229 2VJ2 B 186 - 229 Show 3D Structure View in InterPro
5BO1 A 186 - 229 Show 3D Structure View in InterPro
B 186 - 229 Show 3D Structure View in InterPro
187 - 229 2VJ2 A 187 - 229 Show 3D Structure View in InterPro
EGF 300 - 332 2VJ2 A 300 - 332 Show 3D Structure View in InterPro
B 300 - 332 Show 3D Structure View in InterPro
4CBZ A 300 - 332 Show 3D Structure View in InterPro
4CC0 A 300 - 332 Show 3D Structure View in InterPro
4CC1 A 300 - 332 Show 3D Structure View in InterPro
B 300 - 332 Show 3D Structure View in InterPro
5BO1 A 300 - 332 Show 3D Structure View in InterPro
B 300 - 332 Show 3D Structure View in InterPro
MNNL 32 - 107 4CBZ A 32 - 107 Show 3D Structure View in InterPro
B 32 - 107 Show 3D Structure View in InterPro
4CC0 A 32 - 107 Show 3D Structure View in InterPro
B 32 - 107 Show 3D Structure View in InterPro
4CC1 A 32 - 107 Show 3D Structure View in InterPro
B 32 - 107 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;