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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: WNK1_MOUSE (P83741)

Summary

This is the summary of UniProt entry WNK1_MOUSE (P83741).

Description: Serine/threonine-protein kinase WNK1 {ECO:0000305}
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
View Pfam proteome data.
Length: 2377 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 84
disorder n/a 88 211
low_complexity n/a 100 114
low_complexity n/a 126 140
low_complexity n/a 170 192
coiled_coil n/a 190 217
Pfam Pkinase 221 479
Pfam OSR1_C 500 563
disorder n/a 539 545
disorder n/a 559 560
coiled_coil n/a 565 595
low_complexity n/a 565 591
disorder n/a 569 570
disorder n/a 573 808
low_complexity n/a 733 745
disorder n/a 810 815
disorder n/a 818 819
disorder n/a 830 831
disorder n/a 838 839
low_complexity n/a 864 875
disorder n/a 871 872
disorder n/a 876 883
disorder n/a 885 886
disorder n/a 888 890
disorder n/a 894 895
disorder n/a 899 900
disorder n/a 902 903
disorder n/a 917 923
disorder n/a 930 942
disorder n/a 945 952
disorder n/a 954 955
disorder n/a 965 966
disorder n/a 975 977
disorder n/a 979 981
disorder n/a 985 986
disorder n/a 995 1120
low_complexity n/a 1017 1027
low_complexity n/a 1041 1057
disorder n/a 1126 1132
disorder n/a 1139 1145
disorder n/a 1185 1210
disorder n/a 1212 1216
disorder n/a 1221 1225
disorder n/a 1228 1230
disorder n/a 1233 1234
disorder n/a 1239 1241
disorder n/a 1265 1267
disorder n/a 1274 1277
disorder n/a 1279 1286
disorder n/a 1288 1293
low_complexity n/a 1288 1304
disorder n/a 1300 1324
low_complexity n/a 1344 1356
disorder n/a 1348 1385
low_complexity n/a 1378 1395
disorder n/a 1390 1471
low_complexity n/a 1397 1427
low_complexity n/a 1428 1440
low_complexity n/a 1436 1453
disorder n/a 1493 1509
low_complexity n/a 1495 1514
disorder n/a 1514 1524
disorder n/a 1537 1538
low_complexity n/a 1541 1555
disorder n/a 1547 1554
disorder n/a 1567 1568
disorder n/a 1575 1595
low_complexity n/a 1585 1608
disorder n/a 1598 1599
disorder n/a 1605 1609
disorder n/a 1612 2040
low_complexity n/a 1669 1683
low_complexity n/a 1676 1690
low_complexity n/a 1697 1711
low_complexity n/a 1737 1763
low_complexity n/a 1881 1899
low_complexity n/a 2034 2059
disorder n/a 2043 2097
low_complexity n/a 2054 2065
low_complexity n/a 2062 2075
coiled_coil n/a 2068 2088
disorder n/a 2099 2101
low_complexity n/a 2102 2113
disorder n/a 2106 2194
low_complexity n/a 2115 2139
disorder n/a 2196 2276
low_complexity n/a 2207 2223
low_complexity n/a 2223 2231
disorder n/a 2280 2284
disorder n/a 2287 2288
disorder n/a 2291 2295
disorder n/a 2298 2304
disorder n/a 2306 2309
disorder n/a 2314 2316
disorder n/a 2319 2320
disorder n/a 2322 2352
disorder n/a 2357 2377

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P83741. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE
50
51
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI
100
101
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA
150
151
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ
200
201
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC
250
251
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV
300
301
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL
350
351
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD
400
401
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP
450
451
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI
500
501
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD
550
551
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS
600
601
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV
650
651
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ
700
701
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS
750
751
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQLPVSQTV ATVQGEPHIP
800
801
VSTQPSVVPV HSGAHFLPMG QPIPTSLLPQ YPVSQIPIST PHVSTAQTGF
850
851
SSVPITMAAG INQPLLTLAS SATASSIPGG SPVVPNQLPT LLQPVNQLQS
900
901
QVHPQLLQPT TVQSIGIPAN LGQAAEGPLP SGDVLYQGFP SRLPPQYPGD
950
951
SNIAPSSNVA SVCIHSTVLA PPSMPTEALA TQGYFPTVVQ PYVESTPLVP
1000
1001
MGSVGGQVQV SQPAVSLTQQ PPTTSSQQAV LESTQGVSQA APPEQTPITQ
1050
1051
SQPTQPVPLV TSADSAHSDV ASGMSDGNEN APSSSGRHEG RTTKRHYRKS
1100
1101
VRSRSRHEKT SRPKLRILNV SNKGDRVVEC QLETHNRKMV TFKFDLDGDN
1150
1151
PEEIATIMVN NDFILAIERE SFVAQVREII EKADEMLSED VSVEPEGDQG
1200
1201
LESLQGKDDY GFPGSQKLEG EFKQPIAVSS MPQQIGVPTS SLTQVVHSAG
1250
1251
RRFIVSPVPE SRLRESKVFT SDISDPVVAS TSQAPGMNLS HSASSLSLQQ
1300
1301
AFSELKHGQM TEGPNTAPPN FNHMAGPTFS PFLASIAGVQ TVAASTPSVS
1350
1351
VPITSSPLND ISTSVMQSET ALPTEKGIVG VTTTSTGVVA SGGLTTMSVS
1400
1401
ESPTSSSAVS SSTVPAVVTV STPSQPVQAS TSGSIASSTG SFPPGTFSTT
1450
1451
TATTMGSVVA PDAKPPTVLL QQVASNTAGV AIVTSVSTTT PFPGMASQPS
1500
1501
LPLSSSTSAP TLAETMVVSA HSLDKASHSS TAGLGLSFCA PSSSSSSGTA
1550
1551
VSTSVSQPGM VHPLVISSAV VSTPGLPQPV VPTSTPLLPQ VPNIPPLVQP
1600
1601
VVNVPAVQQT LIHSQPQPAL LPNQPHTHCP EMDADTQSKA PGIDDIKTLE
1650
1651
EKLRSLFSEH SSSGTQHASV SLETPLVVET TVTPGITTTA VAPSKLMTST
1700
1701
TSTCLPPTSL PLGAAGMPVM PVGTPGQVST PGTHASAPVG TATGVKPGTT
1750
1751
PPKPTKTVVP PVGTELSAGT VPCEQLPPFP GPSLIQSQQP LEDLDAQLRR
1800
1801
TLSPETITVA PAVGPLSTMS STTVTEAGTR LQKDGTEGHV TATSSGAGVV
1850
1851
KMGRFQVSVT MDDAQKERKN RSEDTKSVHF ESSTSESSVL SSSSPESTLV
1900
1901
KPEPNGISIS GISLDVPDST HKAPTPEAKS DAGQPTKVGR FQVTTTANKV
1950
1951
GRFSVSRTED KVTELKKEGP VTSPPFRDSE QTVIPAVIPK KEKPELAEPS
2000
2001
HLNGPSSDLE AAFLSRGTED GSGSPHSPPH LCSKSLPVQN LSQSLSNSFN
2050
2051
SSYMSSDNES DIEDEDLRLE LRRLREKHLK EIQDLQSRQK HEIESLYTKL
2100
2101
GKVPPAVIIP PAAPLSGRRR RPTKSKGSKS SRSSSLGNKS PQLSGNLSGQ
2150
2151
SGTSVLHPQQ TLHPAGNTPE TGHNQLLQPL KPSPSSDNLY SAFTSDGAIS
2200
2201
VPSLSAPGQG TSSTNTVGGT VSSQAAQAQP PAMTSSRKGT FTDDLHKLVD
2250
2251
NWARDAMNLS GRRGSKGHMN YEGPGMARKF SAPGQLCVPM TSNLGGSTPI
2300
2301
SAASATSLGH FTKSMCPPQQ YGFPPAPFGT QWSGTGGPAP QPLGQFQPVG
2350
2351
TASLQNFNIS NLQKSISNPP GSNLRTT                         
2377
 

Show the unformatted sequence.

Checksums:
CRC64:0C4D288CCE50B8C6
MD5:522b6e664569102224f8b714d2c0ac9f

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.