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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HPCA_HUMAN (P84074)

Summary

This is the summary of UniProt entry HPCA_HUMAN (P84074).

Description: Neuron-specific calcium-binding protein hippocalcin {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 193 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam EF-hand_8 39 90
Pfam EF-hand_7 98 174
disorder n/a 139 141
disorder n/a 143 154
Pfam EF-hand_1 148 176

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P84074. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK
50
51
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK
100
101
LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
150
151
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF       
193
 

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Checksums:
CRC64:3DBEA176AC945DB1
MD5:d7eb357e22d27e11fb6c1581452d7fb5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EF-hand_1 148 - 176 5G4P A 148 - 176 Jmol OpenAstexViewer
E 148 - 176 Jmol OpenAstexViewer
5G58 A 148 - 176 Jmol OpenAstexViewer
E 148 - 176 Jmol OpenAstexViewer
5M6C A 148 - 176 Jmol OpenAstexViewer
E 148 - 176 Jmol OpenAstexViewer
EF-hand_7 98 - 174 5G4P A 98 - 174 Jmol OpenAstexViewer
E 98 - 174 Jmol OpenAstexViewer
5G58 A 98 - 174 Jmol OpenAstexViewer
E 98 - 174 Jmol OpenAstexViewer
5M6C A 98 - 174 Jmol OpenAstexViewer
E 98 - 174 Jmol OpenAstexViewer
EF-hand_8 39 - 90 5G4P A 39 - 90 Jmol OpenAstexViewer
E 39 - 90 Jmol OpenAstexViewer
5G58 A 39 - 90 Jmol OpenAstexViewer
E 39 - 90 Jmol OpenAstexViewer
5M6C A 39 - 90 Jmol OpenAstexViewer
E 39 - 90 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.