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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ARF1_HUMAN (P84077)

Summary

This is the summary of UniProt entry ARF1_HUMAN (P84077).

Description: ADP-ribosylation factor 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 181 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Arf 3 177
coiled_coil n/a 97 117

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P84077. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
50
51
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
100
101
NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH
150
151
RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ K                    
181
 

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Checksums:
CRC64:AAC773D4A60186B6
MD5:1217c3890953e4f0060d3b6b3ad7970e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Arf 15 - 177 3O47 A 145 - 307 Show 3D Structure View in InterPro
16 - 177 3O47 B 146 - 307 Show 3D Structure View in InterPro
17 - 177 4HMY C 17 - 177 Show 3D Structure View in InterPro
6CM9 C 17 - 177 Show 3D Structure View in InterPro
H 17 - 177 Show 3D Structure View in InterPro
6CRI C 17 - 177 Show 3D Structure View in InterPro
H 17 - 177 Show 3D Structure View in InterPro
K 17 - 177 Show 3D Structure View in InterPro
L 17 - 177 Show 3D Structure View in InterPro
U 17 - 177 Show 3D Structure View in InterPro
V 17 - 177 Show 3D Structure View in InterPro
6D83 C 17 - 177 Show 3D Structure View in InterPro
H 17 - 177 Show 3D Structure View in InterPro
6D84 C 17 - 177 Show 3D Structure View in InterPro
H 17 - 177 Show 3D Structure View in InterPro
I 17 - 177 Show 3D Structure View in InterPro
N 17 - 177 Show 3D Structure View in InterPro
6DFF C 17 - 177 Show 3D Structure View in InterPro
H 17 - 177 Show 3D Structure View in InterPro
7MGE E 17 - 177 Show 3D Structure View in InterPro
18 - 177 1RE0 A 18 - 177 Show 3D Structure View in InterPro
1U81 A 18 - 177 Show 3D Structure View in InterPro
6FAE B 18 - 177 Show 3D Structure View in InterPro
3 - 177 1HUR A 3 - 177 Show 3D Structure View in InterPro
B 3 - 177 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;