Summary
This is the summary of UniProt entry ALK_MOUSE (P97793).
| Description: | ALK tyrosine kinase receptor {ECO:0000305} EC=2.7.10.1 |
| Source organism: |
Mus musculus (Mouse)
(NCBI taxonomy ID
10090)
|
| Length: | 1621 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 23 |
| low_complexity | n/a | 3 | 24 |
| disorder | n/a | 25 | 44 |
| disorder | n/a | 77 | 88 |
| low_complexity | n/a | 99 | 109 |
| disorder | n/a | 114 | 119 |
| disorder | n/a | 121 | 128 |
| disorder | n/a | 195 | 197 |
| disorder | n/a | 205 | 208 |
| low_complexity | n/a | 230 | 242 |
| disorder | n/a | 231 | 239 |
| Pfam | MAM | 270 | 430 |
| disorder | n/a | 291 | 293 |
| disorder | n/a | 303 | 314 |
| disorder | n/a | 318 | 322 |
| disorder | n/a | 324 | 325 |
| disorder | n/a | 392 | 393 |
| Pfam | MAM | 484 | 639 |
| disorder | n/a | 504 | 507 |
| disorder | n/a | 509 | 510 |
| disorder | n/a | 653 | 659 |
| disorder | n/a | 661 | 662 |
| disorder | n/a | 666 | 668 |
| disorder | n/a | 671 | 673 |
| disorder | n/a | 700 | 705 |
| Pfam | Gly_rich | 731 | 991 |
| low_complexity | n/a | 742 | 752 |
| low_complexity | n/a | 801 | 813 |
| disorder | n/a | 816 | 817 |
| low_complexity | n/a | 820 | 827 |
| low_complexity | n/a | 845 | 855 |
| disorder | n/a | 855 | 860 |
| disorder | n/a | 864 | 869 |
| low_complexity | n/a | 865 | 879 |
| disorder | n/a | 871 | 872 |
| low_complexity | n/a | 872 | 886 |
| low_complexity | n/a | 923 | 944 |
| disorder | n/a | 943 | 950 |
| disorder | n/a | 953 | 956 |
| low_complexity | n/a | 1037 | 1057 |
| transmembrane | n/a | 1039 | 1063 |
| Pfam | PK_Tyr_Ser-Thr | 1120 | 1387 |
| disorder | n/a | 1213 | 1215 |
| disorder | n/a | 1345 | 1346 |
| disorder | n/a | 1348 | 1350 |
| disorder | n/a | 1401 | 1403 |
| disorder | n/a | 1407 | 1566 |
| low_complexity | n/a | 1440 | 1454 |
| low_complexity | n/a | 1451 | 1480 |
| low_complexity | n/a | 1551 | 1570 |
| disorder | n/a | 1594 | 1621 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P97793. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MGAAGFLWLL PPLLLAAASY SGAATDQRAG SPASGPPLQP REPLSYSRLQ
50 51
RKSLAVDFVV PSLFRVYARD LLLPQPRSPS EPEAGGLEAR GSLALDCEPL
100 101
LRLLGPLPGI SWADGASSPS PEAGPTLSRV LKGGSVRKLR RAKQLVLELG
150 151
EETILEGCIG PPEEVAAVGI LQFNLSELFS WWILHGEGRL RIRLMPEKKA
200 201
SEVGREGRLS SAIRASQPRL LFQIFGTGHS SMESPSETPS PPGTFMWNLT
250 251
WTMKDSFPFL SHRSRYGLEC SFDFPCELEY SPPLHNHGNQ SWSWRHVPSE
300 301
EASRMNLLDG PEAEHSQEMP RGSFLLLNTS ADSKHTILSP WMRSSSDHCT
350 351
LAVSVHRHLQ PSGRYVAQLL PHNEAGREIL LVPTPGKHGW TVLQGRVGRP
400 401
ANPFRVALEY ISSGNRSLSA VDFFALKNCS EGTSPGSKMA LQSSFTCWNG
450 451
TVLQLGQACD FHQDCAQGED EGQLCSKLPA GFYCNFENGF CGWTQSPLSP
500 501
HMPRWQVRTL RDAHSQGHQG RALLLSTTDI LASEGATVTS ATFPAPMKNS
550 551
PCELRMSWLI RGVLRGNVSL VLVENKTGKE QSRTVWHVAT DEGLSLWQHT
600 601
VLSLLDVTDR FWLQIVTWWG PGSRATVGFD NISISLDCYL TISGEEKMSL
650 651
NSVPKSRNLF EKNPNKESKS WANISGPTPI FDPTVHWLFT TCGASGPHGP
700 701
TQAQCNNAYQ NSNLSVVVGS EGPLKGVQIW KVPATDTYSI SGYGAAGGKG
750 751
GKNTMMRSHG VSVLGIFNLE KGDTLYILVG QQGEDACPRA NQLIQKVCVG
800 801
ENNVIEEEIR VNRSVHEWAG GGGGGGGATY VFKMKDGVPV PLIIAAGGGG
850 851
RAYGAKTETF HPERLESNSS VLGLNGNSGA AGGGGGWNDN TSLLWAGKSL
900 901
LEGAAGGHSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAASNN
950 951
DPEMDGEDGV SFISPLGILY TPALKVMEGH GEVNIKHYLN CSHCEVDECH
1000 1001
MDPESHKVIC FCDHGTVLAD DGVSCIVSPT PEPHLPLSLI LSVVTSALVA
1050 1051
ALVLAFSGIM IVYRRKHQEL QAMQMELQSP EYKLSKLRTS TIMTDYNPNY
1100 1101
CFAGKTSSIS DLKEVPRKNI TLIRGLGHGA FGEVYEGQVS GMPNDPSPLQ
1150 1151
VAVKTLPEVC SEQDELDFLM EALIISKFNH QNIVRCIGVS LQALPRFILL
1200 1201
ELMAGGDLKS FLRETRPRPN QPTSLAMLDL LHVARDIACG CQYLEENHFI
1250 1251
HRDIAARNCL LTCPGAGRIA KIGDFGMARD IYRASYYRKG GCAMLPVKWM
1300 1301
PPEAFMEGIF TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG
1350 1351
RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF AIILERIEYC TQDPDVINTA
1400 1401
LPIEYGPVVE EEEKVPMRPK DPEGMPPLLV SPQPAKHEEA SAAPQPAALT
1450 1451
APGPSVKKPP GAGAGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK
1500 1501
GPGSRNKPTS LWNPTYGSWF TEKPAKKTHP PPGAEPQARA GAAEGGWTGP
1550 1551
GAGPRRAEAA LLLEPSALSA TMKEVPLFRL RHFPCGNVNY GYQQQGLPLE
1600 1601
ATAAPGDTML KSKNKVTQPG P
1621
Show the unformatted sequence. |
| Checksums: |
CRC64:72D1022E117F303E
MD5:fe3357e3e9aff731a45bd58ffb188cf4
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
