Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ALK_MOUSE (P97793)

Summary

This is the summary of UniProt entry ALK_MOUSE (P97793).

Description: ALK tyrosine kinase receptor {ECO:0000305} EC=2.7.10.1
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 1621 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 23
low_complexity n/a 3 24
disorder n/a 25 44
disorder n/a 77 88
low_complexity n/a 99 109
disorder n/a 114 119
disorder n/a 121 128
disorder n/a 195 197
disorder n/a 205 208
low_complexity n/a 230 242
disorder n/a 231 239
Pfam MAM 270 430
disorder n/a 291 293
disorder n/a 303 314
disorder n/a 318 322
disorder n/a 324 325
disorder n/a 392 393
Pfam MAM 484 639
disorder n/a 504 507
disorder n/a 509 510
disorder n/a 653 659
disorder n/a 661 662
disorder n/a 666 668
disorder n/a 671 673
disorder n/a 700 705
Pfam Gly_rich 731 991
low_complexity n/a 742 752
low_complexity n/a 801 813
disorder n/a 816 817
low_complexity n/a 820 827
low_complexity n/a 845 855
disorder n/a 855 860
disorder n/a 864 869
low_complexity n/a 865 879
disorder n/a 871 872
low_complexity n/a 872 886
low_complexity n/a 923 944
disorder n/a 943 950
disorder n/a 953 956
low_complexity n/a 1037 1057
transmembrane n/a 1039 1063
Pfam PK_Tyr_Ser-Thr 1120 1387
disorder n/a 1213 1215
disorder n/a 1345 1346
disorder n/a 1348 1350
disorder n/a 1401 1403
disorder n/a 1407 1566
low_complexity n/a 1440 1454
low_complexity n/a 1451 1480
low_complexity n/a 1551 1570
disorder n/a 1594 1621

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P97793. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAAGFLWLL PPLLLAAASY SGAATDQRAG SPASGPPLQP REPLSYSRLQ
50
51
RKSLAVDFVV PSLFRVYARD LLLPQPRSPS EPEAGGLEAR GSLALDCEPL
100
101
LRLLGPLPGI SWADGASSPS PEAGPTLSRV LKGGSVRKLR RAKQLVLELG
150
151
EETILEGCIG PPEEVAAVGI LQFNLSELFS WWILHGEGRL RIRLMPEKKA
200
201
SEVGREGRLS SAIRASQPRL LFQIFGTGHS SMESPSETPS PPGTFMWNLT
250
251
WTMKDSFPFL SHRSRYGLEC SFDFPCELEY SPPLHNHGNQ SWSWRHVPSE
300
301
EASRMNLLDG PEAEHSQEMP RGSFLLLNTS ADSKHTILSP WMRSSSDHCT
350
351
LAVSVHRHLQ PSGRYVAQLL PHNEAGREIL LVPTPGKHGW TVLQGRVGRP
400
401
ANPFRVALEY ISSGNRSLSA VDFFALKNCS EGTSPGSKMA LQSSFTCWNG
450
451
TVLQLGQACD FHQDCAQGED EGQLCSKLPA GFYCNFENGF CGWTQSPLSP
500
501
HMPRWQVRTL RDAHSQGHQG RALLLSTTDI LASEGATVTS ATFPAPMKNS
550
551
PCELRMSWLI RGVLRGNVSL VLVENKTGKE QSRTVWHVAT DEGLSLWQHT
600
601
VLSLLDVTDR FWLQIVTWWG PGSRATVGFD NISISLDCYL TISGEEKMSL
650
651
NSVPKSRNLF EKNPNKESKS WANISGPTPI FDPTVHWLFT TCGASGPHGP
700
701
TQAQCNNAYQ NSNLSVVVGS EGPLKGVQIW KVPATDTYSI SGYGAAGGKG
750
751
GKNTMMRSHG VSVLGIFNLE KGDTLYILVG QQGEDACPRA NQLIQKVCVG
800
801
ENNVIEEEIR VNRSVHEWAG GGGGGGGATY VFKMKDGVPV PLIIAAGGGG
850
851
RAYGAKTETF HPERLESNSS VLGLNGNSGA AGGGGGWNDN TSLLWAGKSL
900
901
LEGAAGGHSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAASNN
950
951
DPEMDGEDGV SFISPLGILY TPALKVMEGH GEVNIKHYLN CSHCEVDECH
1000
1001
MDPESHKVIC FCDHGTVLAD DGVSCIVSPT PEPHLPLSLI LSVVTSALVA
1050
1051
ALVLAFSGIM IVYRRKHQEL QAMQMELQSP EYKLSKLRTS TIMTDYNPNY
1100
1101
CFAGKTSSIS DLKEVPRKNI TLIRGLGHGA FGEVYEGQVS GMPNDPSPLQ
1150
1151
VAVKTLPEVC SEQDELDFLM EALIISKFNH QNIVRCIGVS LQALPRFILL
1200
1201
ELMAGGDLKS FLRETRPRPN QPTSLAMLDL LHVARDIACG CQYLEENHFI
1250
1251
HRDIAARNCL LTCPGAGRIA KIGDFGMARD IYRASYYRKG GCAMLPVKWM
1300
1301
PPEAFMEGIF TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG
1350
1351
RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF AIILERIEYC TQDPDVINTA
1400
1401
LPIEYGPVVE EEEKVPMRPK DPEGMPPLLV SPQPAKHEEA SAAPQPAALT
1450
1451
APGPSVKKPP GAGAGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK
1500
1501
GPGSRNKPTS LWNPTYGSWF TEKPAKKTHP PPGAEPQARA GAAEGGWTGP
1550
1551
GAGPRRAEAA LLLEPSALSA TMKEVPLFRL RHFPCGNVNY GYQQQGLPLE
1600
1601
ATAAPGDTML KSKNKVTQPG P                               
1621
 

Show the unformatted sequence.

Checksums:
CRC64:72D1022E117F303E
MD5:fe3357e3e9aff731a45bd58ffb188cf4

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;