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65  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: XIAP_HUMAN (P98170)

Summary

This is the summary of UniProt entry XIAP_HUMAN (P98170).

Description: E3 ubiquitin-protein ligase XIAP EC=2.3.2.27
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 497 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam BIR 29 94
disorder n/a 108 109
Pfam BIR 166 231
disorder n/a 248 253
disorder n/a 255 257
Pfam BIR 268 331
disorder n/a 425 432
disorder n/a 434 437
low_complexity n/a 438 447
Pfam zf-C3HC4_3 446 490

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P98170. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTFNSFEGSK TCVPADINKE EEFVEEFNRL KTFANFPSGS PVSASTLARA
50
51
GFLYTGEGDT VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYLEN
100
101
SATQSTNSGI QNGQYKVENY LGSRDHFALD RPSETHADYL LRTGQVVDIS
150
151
DTIYPRNPAM YSEEARLKSF QNWPDYAHLT PRELASAGLY YTGIGDQVQC
200
201
FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE SDAVSSDRNF
250
251
PNSTNLPRNP SMADYEARIF TFGTWIYSVN KEQLARAGFY ALGEGDKVKC
300
301
FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE
350
351
CLVRTTEKTP SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS
400
401
GSNYKSLEVL VADLVNAQKD SMQDESSQTS LQKEISTEEQ LRRLQEEKLC
450
451
KICMDRNIAI VFVPCGHLVT CKQCAEAVDK CPMCYTVITF KQKIFMS   
497
 

Show the unformatted sequence.

Checksums:
CRC64:9D394C16D45EB635
MD5:fd05da3fb84e9e4058be71e0c1491d3d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BIR 166 - 231 1C9Q A 43 - 108 Show 3D Structure View in InterPro
1I3O E 166 - 231 Show 3D Structure View in InterPro
F 166 - 231 Show 3D Structure View in InterPro
4J3Y A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4J44 A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4J45 A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4J46 A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4J47 A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4J48 A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4KJU A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4KJV A 166 - 231 Show 3D Structure View in InterPro
C 166 - 231 Show 3D Structure View in InterPro
4WVS A 166 - 231 Show 3D Structure View in InterPro
4WVT A 166 - 231 Show 3D Structure View in InterPro
B 166 - 231 Show 3D Structure View in InterPro
4WVU A 166 - 231 Show 3D Structure View in InterPro
268 - 331 1F9X A 268 - 331 Show 3D Structure View in InterPro
1G3F A 268 - 331 Show 3D Structure View in InterPro
1G73 C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
1NW9 A 268 - 331 Show 3D Structure View in InterPro
1TFQ A 268 - 331 Show 3D Structure View in InterPro
1TFT A 268 - 331 Show 3D Structure View in InterPro
2JK7 A 268 - 331 Show 3D Structure View in InterPro
2OPY A 268 - 331 Show 3D Structure View in InterPro
2OPZ A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
2VSL A 268 - 331 Show 3D Structure View in InterPro
3CLX A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
3CM2 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
E 268 - 331 Show 3D Structure View in InterPro
F 268 - 331 Show 3D Structure View in InterPro
G 268 - 331 Show 3D Structure View in InterPro
H 268 - 331 Show 3D Structure View in InterPro
I 268 - 331 Show 3D Structure View in InterPro
J 268 - 331 Show 3D Structure View in InterPro
3CM7 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
3EYL A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
3G76 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
E 268 - 331 Show 3D Structure View in InterPro
F 268 - 331 Show 3D Structure View in InterPro
G 268 - 331 Show 3D Structure View in InterPro
H 268 - 331 Show 3D Structure View in InterPro
3HL5 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
4EC4 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
E 268 - 331 Show 3D Structure View in InterPro
F 268 - 331 Show 3D Structure View in InterPro
G 268 - 331 Show 3D Structure View in InterPro
J 268 - 331 Show 3D Structure View in InterPro
K 268 - 331 Show 3D Structure View in InterPro
L 268 - 331 Show 3D Structure View in InterPro
4HY0 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
E 268 - 331 Show 3D Structure View in InterPro
F 268 - 331 Show 3D Structure View in InterPro
G 268 - 331 Show 3D Structure View in InterPro
H 268 - 331 Show 3D Structure View in InterPro
4KMP A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
5C0K A 268 - 331 Show 3D Structure View in InterPro
5C0L A 268 - 331 Show 3D Structure View in InterPro
5C3H A 268 - 331 Show 3D Structure View in InterPro
5C3K A 268 - 331 Show 3D Structure View in InterPro
5C7A A 268 - 331 Show 3D Structure View in InterPro
5C7B A 268 - 331 Show 3D Structure View in InterPro
5C7C A 268 - 331 Show 3D Structure View in InterPro
5C7D A 268 - 331 Show 3D Structure View in InterPro
5C83 A 268 - 331 Show 3D Structure View in InterPro
5C84 A 268 - 331 Show 3D Structure View in InterPro
5M6E A 268 - 331 Show 3D Structure View in InterPro
5M6F A 268 - 331 Show 3D Structure View in InterPro
5M6H A 268 - 331 Show 3D Structure View in InterPro
5M6L A 268 - 331 Show 3D Structure View in InterPro
5M6M A 268 - 331 Show 3D Structure View in InterPro
5OQW A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
6EY2 A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
C 268 - 331 Show 3D Structure View in InterPro
D 268 - 331 Show 3D Structure View in InterPro
E 268 - 331 Show 3D Structure View in InterPro
F 268 - 331 Show 3D Structure View in InterPro
G 268 - 331 Show 3D Structure View in InterPro
H 268 - 331 Show 3D Structure View in InterPro
6H6Q A 268 - 331 Show 3D Structure View in InterPro
B 268 - 331 Show 3D Structure View in InterPro
6H6R A 268 - 331 Show 3D Structure View in InterPro
29 - 93 6QCI D 29 - 93 Show 3D Structure View in InterPro
29 - 94 2POI A 29 - 94 Show 3D Structure View in InterPro
2POP B 1029 - 1094 Show 3D Structure View in InterPro
D 3029 - 3094 Show 3D Structure View in InterPro
2QRA A 29 - 94 Show 3D Structure View in InterPro
B 1029 - 1094 Show 3D Structure View in InterPro
C 2029 - 2094 Show 3D Structure View in InterPro
D 3029 - 3094 Show 3D Structure View in InterPro
4MTZ A 29 - 94 Show 3D Structure View in InterPro
B 1029 - 1094 Show 3D Structure View in InterPro
C 3029 - 3094 Show 3D Structure View in InterPro
D 3029 - 3094 Show 3D Structure View in InterPro
4OXC A 29 - 94 Show 3D Structure View in InterPro
B 29 - 94 Show 3D Structure View in InterPro
C 29 - 94 Show 3D Structure View in InterPro
D 29 - 94 Show 3D Structure View in InterPro
6GJW A 29 - 94 Show 3D Structure View in InterPro
B 29 - 94 Show 3D Structure View in InterPro
C 29 - 94 Show 3D Structure View in InterPro
D 29 - 94 Show 3D Structure View in InterPro
6QCI A 29 - 94 Show 3D Structure View in InterPro
B 29 - 94 Show 3D Structure View in InterPro
C 29 - 94 Show 3D Structure View in InterPro
326 - 327 3UW4 A 318 - 319 Show 3D Structure View in InterPro
3UW5 A 150 - 151 Show 3D Structure View in InterPro
B 150 - 151 Show 3D Structure View in InterPro
zf-C3HC4_3 446 - 449 2KNA A 101 - 104 Show 3D Structure View in InterPro
446 - 490 2ECG A 24 - 68 Show 3D Structure View in InterPro
4IC2 A 446 - 490 Show 3D Structure View in InterPro
B 446 - 490 Show 3D Structure View in InterPro
4IC3 A 446 - 490 Show 3D Structure View in InterPro
B 446 - 490 Show 3D Structure View in InterPro
5O6T A 446 - 490 Show 3D Structure View in InterPro
B 446 - 490 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;