Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DNLJ_MYCTU (P9WNV1)

Summary

This is the summary of UniProt entry DNLJ_MYCTU (P9WNV1).

Description: DNA ligase A {ECO:0000255|HAMAP-Rule:MF_01588}
Source organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (NCBI taxonomy ID 83332)
Length: 691 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 17
Pfam DNA_ligase_aden 11 328
low_complexity n/a 41 56
disorder n/a 55 74
disorder n/a 140 161
disorder n/a 166 167
disorder n/a 172 174
disorder n/a 210 221
Pfam DNA_ligase_OB 331 409
disorder n/a 416 421
Pfam DNA_ligase_ZBD 417 444
disorder n/a 423 425
disorder n/a 427 439
Pfam HHH_2 527 590
Pfam BRCT 607 683

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P9WNV1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSPDADQTA PEVLRQWQAL AEEVREHQFR YYVRDAPIIS DAEFDELLRR
50
51
LEALEEQHPE LRTPDSPTQL VGGAGFATDF EPVDHLERML SLDNAFTADE
100
101
LAAWAGRIHA EVGDAAHYLC ELKIDGVALS LVYREGRLTR ASTRGDGRTG
150
151
EDVTLNARTI ADVPERLTPG DDYPVPEVLE VRGEVFFRLD DFQALNASLV
200
201
EEGKAPFANP RNSAAGSLRQ KDPAVTARRR LRMICHGLGH VEGFRPATLH
250
251
QAYLALRAWG LPVSEHTTLA TDLAGVRERI DYWGEHRHEV DHEIDGVVVK
300
301
VDEVALQRRL GSTSRAPRWA IAYKYPPEEA QTKLLDIRVN VGRTGRITPF
350
351
AFMTPVKVAG STVGQATLHN ASEIKRKGVL IGDTVVIRKA GDVIPEVLGP
400
401
VVELRDGSER EFIMPTTCPE CGSPLAPEKE GDADIRCPNA RGCPGQLRER
450
451
VFHVASRNGL DIEVLGYEAG VALLQAKVIA DEGELFALTE RDLLRTDLFR
500
501
TKAGELSANG KRLLVNLDKA KAAPLWRVLV ALSIRHVGPT AARALATEFG
550
551
SLDAIAAAST DQLAAVEGVG PTIAAAVTEW FAVDWHREIV DKWRAAGVRM
600
601
VDERDESVPR TLAGLTIVVT GSLTGFSRDD AKEAIVARGG KAAGSVSKKT
650
651
NYVVAGDSPG SKYDKAVELG VPILDEDGFR RLLADGPASR T         
691
 

Show the unformatted sequence.

Checksums:
CRC64:94AD5AEDCD065567
MD5:84d22512a8052c69f6cd623b08b0e347

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_ligase_aden 11 - 326 7K72 A 11 - 326 Show 3D Structure View in InterPro
B 11 - 326 Show 3D Structure View in InterPro
C 11 - 326 Show 3D Structure View in InterPro
D 11 - 326 Show 3D Structure View in InterPro
11 - 328 1ZAU A 11 - 328 Show 3D Structure View in InterPro
3SGI A 11 - 328 Show 3D Structure View in InterPro
6KDU A 11 - 328 Show 3D Structure View in InterPro
6KJM A 11 - 328 Show 3D Structure View in InterPro
6KKV A 11 - 328 Show 3D Structure View in InterPro
6KRH A 11 - 328 Show 3D Structure View in InterPro
6KSC A 11 - 328 Show 3D Structure View in InterPro
6KSD A 11 - 328 Show 3D Structure View in InterPro
DNA_ligase_OB 331 - 409 3SGI A 331 - 409 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;