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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PLCB2_HUMAN (Q00722)

Summary

This is the summary of UniProt entry PLCB2_HUMAN (Q00722).

Description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1185 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 3 14
Pfam PH_14 12 141
Pfam EF-hand_like 211 305
disorder n/a 255 258
disorder n/a 270 271
disorder n/a 273 274
disorder n/a 278 279
Pfam PI-PLC-X 314 464
disorder n/a 439 448
disorder n/a 453 455
disorder n/a 459 462
disorder n/a 465 540
low_complexity n/a 499 525
coiled_coil n/a 507 527
Pfam PI-PLC-Y 546 660
Pfam C2 682 784
disorder n/a 719 721
disorder n/a 833 835
disorder n/a 856 889
disorder n/a 893 894
coiled_coil n/a 895 915
low_complexity n/a 901 924
disorder n/a 903 904
disorder n/a 906 916
disorder n/a 925 980
low_complexity n/a 960 975
Pfam PLC-beta_C 978 1153
low_complexity n/a 981 993
low_complexity n/a 986 998
coiled_coil n/a 1003 1053
disorder n/a 1012 1074
coiled_coil n/a 1080 1144
disorder n/a 1086 1089
disorder n/a 1091 1092
disorder n/a 1094 1100
disorder n/a 1105 1107
disorder n/a 1161 1162
disorder n/a 1180 1182

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q00722. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT
50
51
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT
100
101
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK
150
151
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP
200
201
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR
250
251
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN
300
301
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL
350
351
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP
400
401
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS
450
451
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AGEGTVWAGE
500
501
EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV TAYEEMSSLV
550
551
NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM
600
601
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG
650
651
QSGYLLKHEF MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR
700
701
TYVEVELFGL PGDPKRRYRT KLSPSTNSIN PVWKEEPFVF EKILMPELAS
750
751
LRVAVMEEGN KFLGHRIIPI NALNSGYHHL CLHSESNMPL TMPALFIFLE
800
801
MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL PEKPFPLASP
850
851
VASQVNGALA PTSNGSPAAR AGAREEAMKE AAEPRTASLE ELRELKGVVK
900
901
LQRRHEKELR ELERRGARRW EELLQRGAAQ LAELGPPGVG GVGACKLGPG
950
951
KGSRKKRSLP REESAGAAPG EGPEGVDGRV RELKDRLELE LLRQGEEQYE
1000
1001
CVLKRKEQHV AEQISKMMEL AREKQAAELK ALKETSENDT KEMKKKLETK
1050
1051
RLERIQGMTK VTTDKMAQER LKREINNSHI QEVVQVIKQM TENLERHQEK
1100
1101
LEEKQAACLE QIREMEKQFQ KEALAEYEAR MKGLEAEVKE SVRACLRTCF
1150
1151
PSEAKDKPER ACECPPELCE QDPLIAKADA QESRL                
1185
 

Show the unformatted sequence.

Checksums:
CRC64:A0397309D943672A
MD5:0b6dac113655578201d2ab275c3446f0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C2 682 - 784 2FJU B 678 - 780 Show 3D Structure View in InterPro
2ZKM X 678 - 780 Show 3D Structure View in InterPro
EF-hand_like 211 - 305 2FJU B 211 - 305 Show 3D Structure View in InterPro
2ZKM X 211 - 305 Show 3D Structure View in InterPro
PH_14 12 - 141 2FJU B 12 - 141 Show 3D Structure View in InterPro
2ZKM X 12 - 141 Show 3D Structure View in InterPro
PI-PLC-X 314 - 464 2FJU B 314 - 464 Show 3D Structure View in InterPro
2ZKM X 314 - 464 Show 3D Structure View in InterPro
PI-PLC-Y 546 - 660 2FJU B 542 - 656 Show 3D Structure View in InterPro
2ZKM X 542 - 656 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;