Summary
This is the summary of UniProt entry CAC1B_HUMAN (Q00975).
| Description: | Voltage-dependent N-type calcium channel subunit alpha-1B |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 2339 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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| Source | Domain | Start | End |
|---|---|---|---|
| low_complexity | n/a | 8 | 35 |
| disorder | n/a | 13 | 37 |
| Pfam | Ion_trans | 94 | 367 |
| transmembrane | n/a | 97 | 114 |
| disorder | n/a | 123 | 125 |
| transmembrane | n/a | 135 | 156 |
| transmembrane | n/a | 168 | 188 |
| transmembrane | n/a | 200 | 217 |
| transmembrane | n/a | 223 | 245 |
| low_complexity | n/a | 225 | 241 |
| transmembrane | n/a | 300 | 321 |
| transmembrane | n/a | 333 | 355 |
| coiled_coil | n/a | 363 | 383 |
| Pfam | Ion_trans | 481 | 720 |
| transmembrane | n/a | 484 | 504 |
| transmembrane | n/a | 510 | 527 |
| transmembrane | n/a | 548 | 566 |
| transmembrane | n/a | 572 | 589 |
| low_complexity | n/a | 592 | 604 |
| low_complexity | n/a | 607 | 625 |
| transmembrane | n/a | 609 | 631 |
| transmembrane | n/a | 687 | 709 |
| coiled_coil | n/a | 712 | 738 |
| disorder | n/a | 719 | 732 |
| low_complexity | n/a | 727 | 738 |
| disorder | n/a | 767 | 768 |
| disorder | n/a | 791 | 1082 |
| low_complexity | n/a | 845 | 858 |
| low_complexity | n/a | 897 | 925 |
| low_complexity | n/a | 923 | 939 |
| low_complexity | n/a | 951 | 969 |
| low_complexity | n/a | 989 | 1010 |
| coiled_coil | n/a | 992 | 1019 |
| disorder | n/a | 1093 | 1116 |
| Pfam | Ion_trans | 1149 | 1427 |
| transmembrane | n/a | 1151 | 1169 |
| low_complexity | n/a | 1153 | 1168 |
| transmembrane | n/a | 1189 | 1209 |
| transmembrane | n/a | 1221 | 1239 |
| transmembrane | n/a | 1282 | 1304 |
| low_complexity | n/a | 1393 | 1411 |
| transmembrane | n/a | 1394 | 1419 |
| Pfam | Ion_trans | 1470 | 1719 |
| transmembrane | n/a | 1475 | 1493 |
| transmembrane | n/a | 1505 | 1531 |
| low_complexity | n/a | 1563 | 1579 |
| transmembrane | n/a | 1598 | 1616 |
| transmembrane | n/a | 1685 | 1708 |
| Pfam | GPHH | 1728 | 1781 |
| Pfam | Ca_chan_IQ | 1792 | 1869 |
| disorder | n/a | 1840 | 1843 |
| disorder | n/a | 1871 | 1883 |
| disorder | n/a | 1891 | 1893 |
| disorder | n/a | 1916 | 2268 |
| low_complexity | n/a | 2049 | 2064 |
| low_complexity | n/a | 2085 | 2096 |
| low_complexity | n/a | 2089 | 2125 |
| low_complexity | n/a | 2137 | 2152 |
| disorder | n/a | 2270 | 2304 |
| low_complexity | n/a | 2287 | 2303 |
| disorder | n/a | 2311 | 2316 |
| disorder | n/a | 2321 | 2327 |
| disorder | n/a | 2329 | 2335 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q00975. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA
50 51
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
100 101
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
150 151
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
200 201
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
250 251
KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI
300 301
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
350 351
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
400 401
AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR
450 451
ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA
500 501
MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD
550 551
FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV
600 601
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP
650 651
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL
700 701
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA
750 751
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA
800 801
TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR
850 851
HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP
900 901
EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA
950 951
KGERRARHRG GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE
1000 1001
ATEKEAEIVE ADKEKELRNH QPREPHCDLE TSGTVTVGPM HTLPSTCLQK
1050 1051
VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI PVMLTGPLGE ATVVPSGNVD
1100 1101
LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR
1150 1151
YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI
1200 1201
KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL
1250 1251
RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA
1300 1301
VQLFKGKFFY CTDESKELER DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN
1350 1351
VLWALLTLFT VSTGEGWPMV LKHSVDATYE EQGPSPGYRM ELSIFYVVYF
1400 1401
VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI DFAISAKPLT
1450 1451
RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE
1500 1501
LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI
1550 1551
LVTEIAETNN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP
1600 1601
YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR
1650 1651
SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML
1700 1701
NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF
1750 1751
EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR
1800 1801
TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT
1850 1851
VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT
1900 1901
QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE
1950 1951
ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA
2000 2001
SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASSH
2050 2051
HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR
2100 2101
ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT
2150 2151
SPTAGQEPGP HPQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS
2200 2201
ITYKTANSSP IHFAGAQTSL PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP
2250 2251
GSRIGSDPYL GQRLDSEASV HALPEDTLTF EEAVATNSGR SSRTSYVSSL
2300 2301
TSQSHPLRRV PNGYHCTLGL SSGGRARHSY HHPDQDHWC
2339
Show the unformatted sequence. |
| Checksums: |
CRC64:17A45C6D1E76B39D
MD5:04282967eb9d674f3560abe05d43897e
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ion_trans | 1242 - 1269 | 2LCM | A | 1 - 28 | Jmol OpenAstexViewer |
