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88  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MDM2_HUMAN (Q00987)

Summary

This is the summary of UniProt entry MDM2_HUMAN (Q00987).

Description: E3 ubiquitin-protein ligase Mdm2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 491 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 13 15
disorder n/a 19 21
Pfam SWIB 26 101
low_complexity n/a 29 38
disorder n/a 119 130
disorder n/a 133 187
coiled_coil n/a 165 185
low_complexity n/a 201 214
disorder n/a 211 237
disorder n/a 246 249
low_complexity n/a 251 263
disorder n/a 253 295
Pfam zf-RanBP 299 328
disorder n/a 302 303
disorder n/a 333 355
disorder n/a 358 362
disorder n/a 373 402
low_complexity n/a 393 407
disorder n/a 405 427
Pfam zf-C3HC4_3 434 485

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q00987. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
50
51
KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY
100
101
TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS
150
151
HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSIS LSFDESLALC
200
201
VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS VSDQFSVEFE
250
251
VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA
300
301
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS
350
351
TQAEEGFDVP DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS
400
401
SSIIYSSQED VKEFEREETQ DKEESVESSL PLNAIEPCVI CQGRPKNGCI
450
451
VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ PIQMIVLTYF P         
491
 

Show the unformatted sequence.

Checksums:
CRC64:F37CE163876BC983
MD5:d660115260cd44ac16a7f28c9627208c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SWIB 26 - 101 1RV1 A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
1T4E A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
1T4F M 26 - 101 Jmol OpenAstexViewer
1YCR A 26 - 101 Jmol OpenAstexViewer
1Z1M A 26 - 101 Jmol OpenAstexViewer
2AXI A 26 - 101 Jmol OpenAstexViewer
2GV2 A 26 - 101 Jmol OpenAstexViewer
2LZG A 26 - 101 Jmol OpenAstexViewer
2MPS A 26 - 101 Jmol OpenAstexViewer
2RUH A 32 - 107 Jmol OpenAstexViewer
3EQS A 26 - 101 Jmol OpenAstexViewer
3G03 A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
3IWY A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
3JZK A 26 - 101 Jmol OpenAstexViewer
3JZR A 26 - 101 Jmol OpenAstexViewer
3JZS A 26 - 101 Jmol OpenAstexViewer
3LBK A 26 - 101 Jmol OpenAstexViewer
3LBL A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
3LNJ A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
3LNZ A 26 - 101 Jmol OpenAstexViewer
G 26 - 101 Jmol OpenAstexViewer
I 26 - 101 Jmol OpenAstexViewer
K 26 - 101 Jmol OpenAstexViewer
O 26 - 101 Jmol OpenAstexViewer
3TJ2 A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
3TPX A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
3TU1 A 26 - 101 Jmol OpenAstexViewer
3V3B A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
3VBG A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
3VZV A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
3W69 A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
4DIJ A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
4ERE A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
4ERF A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
4HBM A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
F 26 - 101 Jmol OpenAstexViewer
G 26 - 101 Jmol OpenAstexViewer
H 26 - 101 Jmol OpenAstexViewer
4HFZ A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
4HG7 A 26 - 101 Jmol OpenAstexViewer
4JV7 A 26 - 101 Jmol OpenAstexViewer
4JV9 A 26 - 101 Jmol OpenAstexViewer
4JVE A 26 - 101 Jmol OpenAstexViewer
4JVR A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
4JWR A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
4MDN A 26 - 101 Jmol OpenAstexViewer
4MDQ A 26 - 101 Jmol OpenAstexViewer
4OAS A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
4OBA A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
4OCC A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
4ODE A 26 - 101 Jmol OpenAstexViewer
4ODF A 26 - 101 Jmol OpenAstexViewer
4OGN A 26 - 101 Jmol OpenAstexViewer
4OGT A 26 - 101 Jmol OpenAstexViewer
4OGV A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
4OQ3 A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
4QO4 A 26 - 101 Jmol OpenAstexViewer
4QOC A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
G 26 - 101 Jmol OpenAstexViewer
I 26 - 101 Jmol OpenAstexViewer
K 26 - 101 Jmol OpenAstexViewer
4UD7 A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
4UE1 A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
4UMN A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
4WT2 A 26 - 101 Jmol OpenAstexViewer
4ZFI A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
4ZGK A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
4ZYC A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
4ZYF A 26 - 101 Jmol OpenAstexViewer
4ZYI A 26 - 101 Jmol OpenAstexViewer
5AFG A 26 - 101 Jmol OpenAstexViewer
5C5A A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
5HMH A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
5HMI A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
5HMK A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
5J7F A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
5J7G A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
5LAV A 26 - 101 Jmol OpenAstexViewer
5LAW A 26 - 101 Jmol OpenAstexViewer
5LAY A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
F 26 - 101 Jmol OpenAstexViewer
5LAZ A 26 - 101 Jmol OpenAstexViewer
5LN2 A 26 - 101 Jmol OpenAstexViewer
5SWK B 26 - 101 Jmol OpenAstexViewer
5TRF A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
D 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
5VK0 A 26 - 101 Jmol OpenAstexViewer
C 26 - 101 Jmol OpenAstexViewer
E 26 - 101 Jmol OpenAstexViewer
G 26 - 101 Jmol OpenAstexViewer
I 26 - 101 Jmol OpenAstexViewer
K 26 - 101 Jmol OpenAstexViewer
M 26 - 101 Jmol OpenAstexViewer
O 26 - 101 Jmol OpenAstexViewer
Q 26 - 101 Jmol OpenAstexViewer
S 26 - 101 Jmol OpenAstexViewer
U 26 - 101 Jmol OpenAstexViewer
W 26 - 101 Jmol OpenAstexViewer
5WTS B 23 - 98 Jmol OpenAstexViewer
5XXK A 26 - 101 Jmol OpenAstexViewer
B 26 - 101 Jmol OpenAstexViewer
5Z02 A 5 - 80 Jmol OpenAstexViewer
27 - 101 2M86 B 92 - 166 Jmol OpenAstexViewer
3IUX A 27 - 101 Jmol OpenAstexViewer
3LNZ C 27 - 101 Jmol OpenAstexViewer
E 27 - 101 Jmol OpenAstexViewer
M 27 - 101 Jmol OpenAstexViewer
5SWK A 27 - 101 Jmol OpenAstexViewer
5UMM A 27 - 101 Jmol OpenAstexViewer
C 27 - 101 Jmol OpenAstexViewer
28 - 101 3IUX C 28 - 101 Jmol OpenAstexViewer
zf-C3HC4_3 434 - 485 2HDP A 434 - 485 Jmol OpenAstexViewer
B 434 - 485 Jmol OpenAstexViewer
2VJE A 434 - 485 Jmol OpenAstexViewer
C 434 - 485 Jmol OpenAstexViewer
2VJF A 434 - 485 Jmol OpenAstexViewer
C 434 - 485 Jmol OpenAstexViewer
5MNJ C 434 - 485 Jmol OpenAstexViewer
G 434 - 485 Jmol OpenAstexViewer
zf-RanBP 299 - 328 2C6A A 299 - 328 Jmol OpenAstexViewer
2C6B A 299 - 328 Jmol OpenAstexViewer
4XXB B 299 - 328 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.