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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPTB2_HUMAN (Q01082)

Summary

This is the summary of UniProt entry SPTB2_HUMAN (Q01082).

Description: Spectrin beta chain, non-erythrocytic 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2364 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 20 34
Pfam CH 54 159
coiled_coil n/a 113 133
Pfam CH 173 279
Pfam Spectrin 302 412
Pfam Spectrin 422 526
coiled_coil n/a 457 491
low_complexity n/a 472 491
low_complexity n/a 508 525
Pfam Spectrin 528 636
low_complexity n/a 626 640
Pfam Spectrin 638 742
low_complexity n/a 713 724
Pfam Spectrin 744 847
disorder n/a 804 823
Pfam Spectrin 849 953
disorder n/a 918 931
Pfam Spectrin 955 1060
coiled_coil n/a 991 1032
disorder n/a 1017 1028
Pfam Spectrin 1062 1167
disorder n/a 1085 1102
coiled_coil n/a 1097 1124
disorder n/a 1105 1106
disorder n/a 1111 1116
disorder n/a 1118 1127
Pfam Spectrin 1169 1272
disorder n/a 1187 1189
disorder n/a 1195 1196
disorder n/a 1201 1208
disorder n/a 1210 1216
disorder n/a 1219 1222
disorder n/a 1240 1241
disorder n/a 1246 1259
disorder n/a 1261 1268
Pfam Spectrin 1275 1378
Pfam Spectrin 1380 1483
coiled_coil n/a 1422 1456
disorder n/a 1430 1434
disorder n/a 1436 1455
disorder n/a 1457 1458
Pfam Spectrin 1485 1590
disorder n/a 1510 1512
disorder n/a 1535 1539
disorder n/a 1545 1546
Pfam Spectrin 1592 1696
disorder n/a 1613 1615
disorder n/a 1618 1619
disorder n/a 1624 1625
disorder n/a 1627 1628
disorder n/a 1654 1667
disorder n/a 1670 1671
Pfam Spectrin 1698 1803
disorder n/a 1761 1762
Pfam Spectrin 1805 1909
disorder n/a 1829 1837
disorder n/a 1839 1841
coiled_coil n/a 1853 1880
Pfam Spectrin 1912 2015
coiled_coil n/a 1985 2005
Pfam Spectrin 2017 2100
low_complexity n/a 2076 2089
disorder n/a 2084 2215
low_complexity n/a 2088 2106
Pfam PH 2198 2307
disorder n/a 2240 2241
disorder n/a 2248 2249
disorder n/a 2310 2356
low_complexity n/a 2344 2356

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q01082. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD
50
51
EREAVQKKTF TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL
100
101
PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI
150
151
WTIILRFQIQ DISVETEDNK EKKSAKDALL LWCQMKTAGY PNVNIHNFTT
200
201
SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL
250
251
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
300
301
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV
350
351
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE
400
401
KAEHERELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF
450
451
GFDLPAVEAA TKKHEAIETD IAAYEERVQA VVAVARELEA ENYHDIKRIT
500
501
ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI MDWMDEMKVL
550
551
VLSQDYGKHL LGVEDLLQKH TLVEADIGIQ AERVRGVNAS AQKFATDGEG
600
601
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE
650
651
EGWIREKEKI LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE
700
701
GEDMIAEEHF GSEKIRERII YIREQWANLE QLSAIRKKRL EEASLLHQFQ
750
751
ADADDIDAWM LDILKIVSSS DVGHDEYSTQ SLVKKHKDVA EEIANYRPTL
800
801
DTLHEQASAL PQEHAESPDV RGRLSGIEER YKEVAELTRL RKQALQDTLA
850
851
LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
900
901
QASRVAVVNQ IARQLMHSGH PSEKEIKAQQ DKLNTRWSQF RELVDRKKDA
950
951
LLSALSIQNY HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG
1000
1001
MERDLVAIEA KLSDLQKEAE KLESEHPDQA QAILSRLAEI SDVWEEMKTT
1050
1051
LKNREASLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLTEAEKL
1100
1101
LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG
1150
1151
WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT
1200
1201
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV
1250
1251
DSIDDRHRKN RETASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD
1300
1301
MSYDEARNLH SKWLKHQAFM AELASNKEWL DKIEKEGMQL ISEKPETEAV
1350
1351
VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN KAELFTQSCA DLDKWLHGLE
1400
1401
SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ SQAQALSQEG
1450
1451
KSTDEVDSKR LTVQTKFMEL LEPLNERKHN LLASKEIHQF NRDVEDEILW
1500
1501
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN
1550
1551
IVTDSSSLSA EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHRAQQYYFD
1600
1601
AAEAEAWMSE QELYMMSEEK AKDEQSAVSM LKKHQILEQA VEDYAETVHQ
1650
1651
LSKTSRALVA DSHPESERIS MRQSKVDKLY AGLKDLAEER RGKLDERHRL
1700
1701
FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF REFARDTGNI
1750
1751
GQERVDTVNH LADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI
1800
1801
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE
1850
1851
HDIQALGTQV RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC
1900
1901
ESRRVRLVDT GDKFRFFSMV RDLMLWMEDV IRQIEAQEKP RDVSSVELLM
1950
1951
NNHQGIKAEI DARNDSFTTC IELGKSLLAR KHYASEEIKE KLLQLTEKRK
2000
2001
EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL SSREIGQSVD
2050
2051
EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP
2100
2101
PSPEPSTKVS EEAESQQQWD TSKGEQVSQN GLPAEQGSPR MAETVDTSEM
2150
2151
VNGATEQRTS SKESSPIPSP TSDRKAKTAL PAQSAATLPA RTQETPSAQM
2200
2201
EGFLNRKHEW EAHNKKASSR SWHNVYCVIN NQEMGFYKDA KTAASGIPYH
2250
2251
SEVPVSLKEA VCEVALDYKK KKHVFKLRLN DGNEYLFQAK DDEEMNTWIQ
2300
2301
AISSAISSDK HEVSASTQST PASSRAQTLP TSVVTITSES SPGKREKDKE
2350
2351
KDKEKRFSLF GKKK                                       
2364
 

Show the unformatted sequence.

Checksums:
CRC64:1770C3B0EB07B892
MD5:5227f55af3c161cfd7a0c9f45f64165d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CH 173 - 279 1AA2 A 2 - 108 NGL View in InterPro
1BKR A 2 - 108 NGL View in InterPro
Spectrin 1698 - 1803 3EDV A 1698 - 1803 NGL View in InterPro
B 1698 - 1803 NGL View in InterPro
1805 - 1909 3EDV A 1805 - 1909 NGL View in InterPro
B 1805 - 1909 NGL View in InterPro
1912 - 2014 3EDV B 1912 - 2014 NGL View in InterPro
1912 - 2015 3EDV A 1912 - 2015 NGL View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in yellow.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.