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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TIAR_HUMAN (Q01085)

Summary

This is the summary of UniProt entry TIAR_HUMAN (Q01085).

Description: Nucleolysin TIAR
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 375 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam RRM_1 11 79
disorder n/a 84 87
Pfam RRM_1 99 169
disorder n/a 169 195
Pfam RRM_1 207 271
disorder n/a 342 367
low_complexity n/a 342 365
disorder n/a 369 371

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q01085. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEHTSNDPY
50
51
CFVEFYEHRD AAAALAAMNG RKILGKEVKV NWATTPSSQK KDTSNHFHVF
100
101
VGDLSPEITT EDIKSAFAPF GKISDARVVK DMATGKSKGY GFVSFYNKLD
150
151
AENAIVHMGG QWLGGRQIRT NWATRKPPAP KSTQENNTKQ LRFEDVVNQS
200
201
SPKNCTVYCG GIASGLTDQL MRQTFSPFGQ IMEIRVFPEK GYSFVRFSTH
250
251
ESAAHAIVSV NGTTIEGHVV KCYWGKESPD MTKNFQQVDY SQWGQWSQVY
300
301
GNPQQYGQYM ANGWQVPPYG VYGQPWNQQG FGVDQSPSAA WMGGFGAQPP
350
351
QGQAPPPVIP PPNQAGYGMA SYQTQ                           
375
 

Show the unformatted sequence.

Checksums:
CRC64:2F8D1C7169A7817E
MD5:628d22a00ab647784e6fcdde1de95e29

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RRM_1 11 - 79 2CQI A 11 - 79 Jmol OpenAstexViewer
207 - 271 1X4G A 28 - 92 Jmol OpenAstexViewer
99 - 169 2DH7 A 99 - 169 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.