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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FOXK2_HUMAN (Q01167)

Summary

This is the summary of UniProt entry FOXK2_HUMAN (Q01167).

Description: Forkhead box protein K2 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 660 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 2 34
disorder n/a 3 36
Pfam FHA 54 145
disorder n/a 59 63
disorder n/a 67 70
disorder n/a 78 109
low_complexity n/a 85 101
disorder n/a 154 181
disorder n/a 190 193
disorder n/a 195 198
disorder n/a 202 224
disorder n/a 229 261
Pfam Forkhead 257 343
disorder n/a 317 319
disorder n/a 327 335
disorder n/a 342 346
disorder n/a 353 355
disorder n/a 357 418
disorder n/a 420 421
disorder n/a 423 424
disorder n/a 430 436
low_complexity n/a 449 471
disorder n/a 450 470
low_complexity n/a 464 476
low_complexity n/a 500 513
disorder n/a 507 533
disorder n/a 544 547
low_complexity n/a 545 564
disorder n/a 556 560
disorder n/a 568 641
disorder n/a 643 660

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q01167. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAAALSG AGTPPAGGGA GGGGAGGGGS PPGGWAVARL EGREFEYLMK
50
51
KRSVTIGRNS SQGSVDVSMG HSSFISRRHL EIFTPPGGGG HGGAAPELPP
100
101
AQPRPDAGGD FYLRCLGKNG VFVDGVFQRR GAPPLQLPRV CTFRFPSTNI
150
151
KITFTALSSE KREKQEASES PVKAVQPHIS PLTINIPDTM AHLISPLPSP
200
201
TGTISAANSC PSSPRGAGSS GYKVGRVMPS DLNLMADNSQ PENEKEASGG
250
251
DSPKDDSKPP YSYAQLIVQA ITMAPDKQLT LNGIYTHITK NYPYYRTADK
300
301
GWQNSIRHNL SLNRYFIKVP RSQEEPGKGS FWRIDPASES KLIEQAFRKR
350
351
RPRGVPCFRT PLGPLSSRSA PASPNHAGVL SAHSSGAQTP ESLSREGSPA
400
401
PLEPEPGAAQ PKLAVIQEAR FAQSAPGSPL SSQPVLITVQ RQLPQAIKPV
450
451
TYTVATPVTT STSQPPVVQT VHVVHQIPAV SVTSVAGLAP ANTYTVSGQA
500
501
VVTPAAVLAP PKAEAQENGD HREVKVKVEP IPAIGHATLG TASRIIQTAQ
550
551
TTPVQTVTIV QQAPLGQHQL PIKTVTQNGT HVASVPTAVH GQVNNAAASP
600
601
LHMLATHASA SASLPTKRHN GDQPEQPELK RIKTEDGEGI VIALSVDTPP
650
651
AAVREKGVQN                                            
660
 

Show the unformatted sequence.

Checksums:
CRC64:E11C0B24370F1260
MD5:097a37998110b71b83ebf4702e61c391

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Forkhead 257 - 343 1JXS A 2 - 88 Show 3D Structure View in InterPro
2C6Y A 2 - 88 Show 3D Structure View in InterPro
B 2 - 88 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;