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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FLI1_HUMAN (Q01543)

Summary

This is the summary of UniProt entry FLI1_HUMAN (Q01543).

Description: Friend leukemia integration 1 transcription factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 452 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 4 7
disorder n/a 9 11
disorder n/a 22 65
disorder n/a 68 79
disorder n/a 87 88
disorder n/a 99 129
Pfam SAM_PNT 114 198
disorder n/a 209 218
disorder n/a 225 229
disorder n/a 232 271
Pfam Ets 282 361
disorder n/a 311 327
disorder n/a 398 399
disorder n/a 401 404
disorder n/a 430 431
disorder n/a 433 440
disorder n/a 442 444

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q01543. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP
50
51
LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM
100
101
NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS
150
151
LMEIDTSFFQ NMDGKELCKM NKEDFLRATT LYNTEVLLSH LSYLRESSLL
200
201
AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK SPPLGGAQTI
250
251
SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
300
301
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK
350
351
VHGKRYAYKF DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF
400
401
VPPHPSSMPV TSSSFFGAAS QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS
450
451
YY                                                    
452
 

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Checksums:
CRC64:9C2AAEEAF683F3FA
MD5:f47f296a7d784258f7b264d7a168e64d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ets 282 - 361 1FLI A 282 - 361 Jmol OpenAstexViewer
5E8G A 282 - 361 Jmol OpenAstexViewer
B 282 - 361 Jmol OpenAstexViewer
C 282 - 361 Jmol OpenAstexViewer
D 282 - 361 Jmol OpenAstexViewer
5E8I A 282 - 361 Jmol OpenAstexViewer
D 282 - 361 Jmol OpenAstexViewer
G 282 - 361 Jmol OpenAstexViewer
J 282 - 361 Jmol OpenAstexViewer
5JVT A 282 - 361 Jmol OpenAstexViewer
D 282 - 361 Jmol OpenAstexViewer
G 282 - 361 Jmol OpenAstexViewer
SAM_PNT 114 - 198 1X66 A 8 - 92 Jmol OpenAstexViewer
2YTU A 22 - 106 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.