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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: EWS_HUMAN (Q01844)

Summary

This is the summary of UniProt entry EWS_HUMAN (Q01844).

Description: RNA-binding protein EWS
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 656 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 5 23
disorder n/a 34 38
disorder n/a 40 49
low_complexity n/a 50 70
disorder n/a 52 57
disorder n/a 63 102
low_complexity n/a 69 84
low_complexity n/a 90 120
disorder n/a 104 106
disorder n/a 109 112
disorder n/a 114 368
low_complexity n/a 119 136
low_complexity n/a 181 213
low_complexity n/a 212 247
low_complexity n/a 245 265
low_complexity n/a 299 331
low_complexity n/a 335 356
Pfam RRM_1 363 441
disorder n/a 384 386
disorder n/a 388 389
disorder n/a 392 432
disorder n/a 438 531
low_complexity n/a 453 512
Pfam zf-RanBP 518 549
disorder n/a 533 656
low_complexity n/a 549 585
low_complexity n/a 578 623
low_complexity n/a 629 639

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q01844. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV
50
51
SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT
100
101
TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ
150
151
PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP
200
201
TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA
250
251
PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR
300
301
GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP
350
351
PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI
400
401
YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP
450
451
MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR
500
501
GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG
550
551
FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR
600
601
GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE
650
651
RRDRPY                                                
656
 

Show the unformatted sequence.

Checksums:
CRC64:0DA02CEE146720BB
MD5:68c5d4bccbbd2dc851fd12104d1c381c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RRM_1 363 - 441 2CPE A 363 - 441 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.