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15  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TIE2_HUMAN (Q02763)

Summary

This is the summary of UniProt entry TIE2_HUMAN (Q02763).

Description: Angiopoietin-1 receptor EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1124 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 3 18
Pfam Ig_Tie2_1 24 118
Pfam fn3 445 530
low_complexity n/a 520 535
disorder n/a 527 539
low_complexity n/a 542 553
Pfam fn3 544 626
disorder n/a 578 579
disorder n/a 587 589
Pfam fn3 640 724
transmembrane n/a 746 770
Pfam PK_Tyr_Ser-Thr 824 1092
low_complexity n/a 931 942

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q02763. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDSLASLVLC GVSLLLSGTV EGAMDLILIN SLPLVSDAET SLTCIASGWR
50
51
PHEPITIGRD FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY
100
101
FCEGRVRGEA IRIRTMKMRQ QASFLPATLT MTVDKGDNVN ISFKKVLIKE
150
151
EDAVIYKNGS FIHSVPRHEV PDILEVHLPH AQPQDAGVYS ARYIGGNLFT
200
201
SAFTRLIVRR CEAQKWGPEC NHLCTACMNN GVCHEDTGEC ICPPGFMGRT
250
251
CEKACELHTF GRTCKERCSG QEGCKSYVFC LPDPYGCSCA TGWKGLQCNE
300
301
ACHPGFYGPD CKLRCSCNNG EMCDRFQGCL CSPGWQGLQC EREGIQRMTP
350
351
KIVDLPDHIE VNSGKFNPIC KASGWPLPTN EEMTLVKPDG TVLHPKDFNH
400
401
TDHFSVAIFT IHRILPPDSG VWVCSVNTVA GMVEKPFNIS VKVLPKPLNA
450
451
PNVIDTGHNF AVINISSEPY FGDGPIKSKK LLYKPVNHYE AWQHIQVTNE
500
501
IVTLNYLEPR TEYELCVQLV RRGEGGEGHP GPVRRFTTAS IGLPPPRGLN
550
551
LLPKSQTTLN LTWQPIFPSS EDDFYVEVER RSVQKSDQQN IKVPGNLTSV
600
601
LLNNLHPREQ YVVRARVNTK AQGEWSEDLT AWTLSDILPP QPENIKISNI
650
651
THSSAVISWT ILDGYSISSI TIRYKVQGKN EDQHVDVKIK NATITQYQLK
700
701
GLEPETAYQV DIFAENNIGS SNPAFSHELV TLPESQAPAD LGGGKMLLIA
750
751
ILGSAGMTCL TVLLAFLIIL QLKRANVQRR MAQAFQNVRE EPAVQFNSGT
800
801
LALNRKVKNN PDPTIYPVLD WNDIKFQDVI GEGNFGQVLK ARIKKDGLRM
850
851
DAAIKRMKEY ASKDDHRDFA GELEVLCKLG HHPNIINLLG ACEHRGYLYL
900
901
AIEYAPHGNL LDFLRKSRVL ETDPAFAIAN STASTLSSQQ LLHFAADVAR
950
951
GMDYLSQKQF IHRDLAARNI LVGENYVAKI ADFGLSRGQE VYVKKTMGRL
1000
1001
PVRWMAIESL NYSVYTTNSD VWSYGVLLWE IVSLGGTPYC GMTCAELYEK
1050
1051
LPQGYRLEKP LNCDDEVYDL MRQCWREKPY ERPSFAQILV SLNRMLEERK
1100
1101
TYVNTTLYEK FTYAGIDCSA EEAA                            
1124
 

Show the unformatted sequence.

Checksums:
CRC64:E739DEC3E4FEB124
MD5:1409a6a3e2e73fd8d0d60e56f0585b8f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
fn3 445 - 530 4K0V A 445 - 530 Show 3D Structure View in InterPro
5MYA A 445 - 530 Show 3D Structure View in InterPro
5UTK A 445 - 530 Show 3D Structure View in InterPro
B 445 - 530 Show 3D Structure View in InterPro
544 - 626 5MYA A 544 - 626 Show 3D Structure View in InterPro
B 544 - 626 Show 3D Structure View in InterPro
5MYB A 544 - 626 Show 3D Structure View in InterPro
B 544 - 626 Show 3D Structure View in InterPro
5UTK A 544 - 626 Show 3D Structure View in InterPro
B 544 - 626 Show 3D Structure View in InterPro
640 - 724 5MYA A 640 - 724 Show 3D Structure View in InterPro
B 640 - 724 Show 3D Structure View in InterPro
5MYB A 640 - 724 Show 3D Structure View in InterPro
B 640 - 724 Show 3D Structure View in InterPro
5UTK A 640 - 724 Show 3D Structure View in InterPro
B 640 - 724 Show 3D Structure View in InterPro
Ig_Tie2_1 24 - 118 2GY5 A 24 - 118 Show 3D Structure View in InterPro
2GY7 B 24 - 118 Show 3D Structure View in InterPro
4K0V A 24 - 118 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 824 - 1092 1FVR A 824 - 1092 Show 3D Structure View in InterPro
B 824 - 1092 Show 3D Structure View in InterPro
2WQB A 824 - 1092 Show 3D Structure View in InterPro
3L8P A 824 - 1092 Show 3D Structure View in InterPro
6MWE A 824 - 1092 Show 3D Structure View in InterPro
B 824 - 1092 Show 3D Structure View in InterPro
836 - 1092 2OO8 X 836 - 1092 Show 3D Structure View in InterPro
2P4I B 836 - 1092 Show 3D Structure View in InterPro
837 - 1092 2OSC A 837 - 1092 Show 3D Structure View in InterPro
838 - 1092 2P4I A 838 - 1092 Show 3D Structure View in InterPro
4X3J A 838 - 1092 Show 3D Structure View in InterPro
917 - 935 3BEA A 679 - 697 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;