Summary
This is the summary of UniProt entry GSTM4_HUMAN (Q03013).
Description: | Glutathione S-transferase Mu 4 EC=2.5.1.18 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 218 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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Source | Domain | Start | End |
---|---|---|---|
Pfam | GST_N | 3 | 82 |
Pfam | GST_C_3 | 105 | 201 |
low_complexity | n/a | 120 | 131 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q03013. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MSMTLGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK
50 51
FKLGLDFPNL PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL
100 101
ENQAMDVSNQ LARVCYSPDF EKLKPEYLEE LPTMMQHFSQ FLGKRPWFVG
150 151
DKITFVDFLA YDVLDLHRIF EPNCLDAFPN LKDFISRFEG LEKISAYMKS
200 201
SRFLPKPLYT RVAVWGNK
218
Show the unformatted sequence. |
Checksums: |
CRC64:35E96FA54D566B1E
MD5:1d5d2194b627c9c0b6573b74b0f3b07a
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
---|---|---|---|---|---|
GST_C_3 | 105 - 201 | 4GTU | A | 104 - 200 | Jmol OpenAstexViewer |
B | 104 - 200 | Jmol OpenAstexViewer | |||
C | 104 - 200 | Jmol OpenAstexViewer | |||
D | 104 - 200 | Jmol OpenAstexViewer | |||
E | 104 - 200 | Jmol OpenAstexViewer | |||
F | 104 - 200 | Jmol OpenAstexViewer | |||
G | 104 - 200 | Jmol OpenAstexViewer | |||
H | 104 - 200 | Jmol OpenAstexViewer | |||
GST_N | 3 - 82 | 4GTU | A | 2 - 81 | Jmol OpenAstexViewer |
B | 2 - 81 | Jmol OpenAstexViewer | |||
C | 2 - 81 | Jmol OpenAstexViewer | |||
D | 2 - 81 | Jmol OpenAstexViewer | |||
E | 2 - 81 | Jmol OpenAstexViewer | |||
F | 2 - 81 | Jmol OpenAstexViewer | |||
G | 2 - 81 | Jmol OpenAstexViewer | |||
H | 2 - 81 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.