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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ENL_HUMAN (Q03111)

Summary

This is the summary of UniProt entry ENL_HUMAN (Q03111).

Description: Protein ENL
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 559 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam YEATS 27 108
disorder n/a 117 121
disorder n/a 143 488
low_complexity n/a 202 221
low_complexity n/a 239 255
low_complexity n/a 268 288
low_complexity n/a 292 315
low_complexity n/a 308 336
low_complexity n/a 369 396
low_complexity n/a 411 424
low_complexity n/a 434 454
low_complexity n/a 450 468
disorder n/a 490 492
Pfam AHD 495 555

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q03111. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK
50
51
VVFWLHDSFP KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF
100
101
TYDLFLNLEG NPPVNHLRCE KLTFNNPTTE FRYKLLRAGG VMVMPEGADT
150
151
VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG SKDANKESSK TSKPHKVTKE
200
201
HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK EEKAPPPKAA
250
251
FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ
300
301
KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA
350
351
KKALEVEESN SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG
400
401
PLRSMVEDLQ SEESDEDDSS SGEEAAGKTN PGRDSRLSFS DSESDNSADS
450
451
SLPSREPPPP QKPPPPNSKV SGRRSPESCS KPEKILKKGT YDKAYTDELV
500
501
ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF SLDETTVRKL
550
551
QSCLEAVAT                                             
559
 

Show the unformatted sequence.

Checksums:
CRC64:A8480BA0F8742173
MD5:a706bd6494d04cb2e3ab37330467c3b9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
YEATS 27 - 108 5J9S A 27 - 108 Show 3D Structure View in InterPro
6HPW A 27 - 108 Show 3D Structure View in InterPro
6HPX A 27 - 108 Show 3D Structure View in InterPro
6HPY A 27 - 108 Show 3D Structure View in InterPro
6HPZ A 27 - 108 Show 3D Structure View in InterPro
6HQ0 A 27 - 108 Show 3D Structure View in InterPro
6HT0 A 27 - 108 Show 3D Structure View in InterPro
6HT1 A 27 - 108 Show 3D Structure View in InterPro
6T1I A 27 - 108 Show 3D Structure View in InterPro
6T1J A 27 - 108 Show 3D Structure View in InterPro
6T1L A 27 - 108 Show 3D Structure View in InterPro
6T1M A 27 - 108 Show 3D Structure View in InterPro
6T1N A 27 - 108 Show 3D Structure View in InterPro
6T1O A 27 - 108 Show 3D Structure View in InterPro
7B0T A 27 - 108 Show 3D Structure View in InterPro
7B10 A 27 - 108 Show 3D Structure View in InterPro
7E74 A 27 - 108 Show 3D Structure View in InterPro
B 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
D 27 - 108 Show 3D Structure View in InterPro
7E7A A 27 - 108 Show 3D Structure View in InterPro
B 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
D 27 - 108 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;