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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DYN1_HUMAN (Q05193)

Summary

This is the summary of UniProt entry DYN1_HUMAN (Q05193).

Description: Dynamin-1 EC=3.6.5.5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 864 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Dynamin_N 34 207
disorder n/a 185 189
Pfam Dynamin_M 216 502
coiled_coil n/a 297 317
disorder n/a 316 318
disorder n/a 463 464
disorder n/a 504 510
Pfam PH 520 624
low_complexity n/a 553 561
disorder n/a 631 653
Pfam GED 654 745
disorder n/a 712 730
disorder n/a 743 864
low_complexity n/a 746 760
low_complexity n/a 782 815
low_complexity n/a 818 829
low_complexity n/a 850 860

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q05193. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN
50
51
FVGRDFLPRG SGIVTRRPLV LQLVNATTEY AEFLHCKGKK FTDFEEVRLE
100
101
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP
150
151
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKVA KEVDPQGQRT
200
201
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
250
251
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL
300
301
QSQLLSIEKE VEEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ
350
351
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT
400
401
GLFTPDMAFE TIVKKQVKKI REPCLKCVDM VISELISTVR QCTKKLQQYP
450
451
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ
500
501
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL
550
551
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY
600
601
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS
650
651
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE
700
701
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV
750
751
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP
800
801
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA
850
851
SPSRPESPRP PFDL                                       
864
 

Show the unformatted sequence.

Checksums:
CRC64:7FCD8CB572FFEAEF
MD5:995204a1b0d4ac530bcd0970446db288

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Dynamin_M 216 - 311 3ZYC A 216 - 311 Jmol OpenAstexViewer
3ZYS A 216 - 311 Jmol OpenAstexViewer
D 216 - 311 Jmol OpenAstexViewer
4UUD A 216 - 311 Jmol OpenAstexViewer
G 216 - 311 Jmol OpenAstexViewer
4UUK A 216 - 311 Jmol OpenAstexViewer
G 216 - 311 Jmol OpenAstexViewer
216 - 312 5D3Q A 216 - 312 Jmol OpenAstexViewer
216 - 314 2X2F A 216 - 314 Jmol OpenAstexViewer
216 - 316 5D3Q B 216 - 316 Jmol OpenAstexViewer
216 - 317 2X2F D 216 - 317 Jmol OpenAstexViewer
216 - 319 3ZYC D 216 - 319 Jmol OpenAstexViewer
4UUD D 216 - 319 Jmol OpenAstexViewer
K 216 - 319 Jmol OpenAstexViewer
4UUK D 216 - 319 Jmol OpenAstexViewer
K 216 - 319 Jmol OpenAstexViewer
216 - 320 2X2E A 216 - 320 Jmol OpenAstexViewer
D 216 - 320 Jmol OpenAstexViewer
216 - 499 3SNH A 216 - 499 Jmol OpenAstexViewer
325 - 496 4UUD B 325 - 496 Jmol OpenAstexViewer
E 325 - 496 Jmol OpenAstexViewer
I 325 - 496 Jmol OpenAstexViewer
J 325 - 496 Jmol OpenAstexViewer
4UUK B 325 - 496 Jmol OpenAstexViewer
E 325 - 496 Jmol OpenAstexViewer
I 325 - 496 Jmol OpenAstexViewer
J 325 - 496 Jmol OpenAstexViewer
Dynamin_N 34 - 207 2X2E A 34 - 207 Jmol OpenAstexViewer
D 34 - 207 Jmol OpenAstexViewer
2X2F A 34 - 207 Jmol OpenAstexViewer
D 34 - 207 Jmol OpenAstexViewer
3SNH A 34 - 207 Jmol OpenAstexViewer
3ZYC A 34 - 207 Jmol OpenAstexViewer
D 34 - 207 Jmol OpenAstexViewer
3ZYS A 34 - 207 Jmol OpenAstexViewer
D 34 - 207 Jmol OpenAstexViewer
4UUD A 34 - 207 Jmol OpenAstexViewer
D 34 - 207 Jmol OpenAstexViewer
G 34 - 207 Jmol OpenAstexViewer
K 34 - 207 Jmol OpenAstexViewer
4UUK A 34 - 207 Jmol OpenAstexViewer
D 34 - 207 Jmol OpenAstexViewer
G 34 - 207 Jmol OpenAstexViewer
K 34 - 207 Jmol OpenAstexViewer
5D3Q A 34 - 207 Jmol OpenAstexViewer
B 34 - 207 Jmol OpenAstexViewer
GED 654 - 707 4UUD B 654 - 707 Jmol OpenAstexViewer
E 654 - 707 Jmol OpenAstexViewer
I 654 - 707 Jmol OpenAstexViewer
J 654 - 707 Jmol OpenAstexViewer
4UUK B 654 - 707 Jmol OpenAstexViewer
E 654 - 707 Jmol OpenAstexViewer
I 654 - 707 Jmol OpenAstexViewer
J 654 - 707 Jmol OpenAstexViewer
654 - 745 3SNH A 654 - 745 Jmol OpenAstexViewer
726 - 745 3ZYS A 726 - 745 Jmol OpenAstexViewer
D 726 - 745 Jmol OpenAstexViewer
4UUD A 726 - 745 Jmol OpenAstexViewer
D 726 - 745 Jmol OpenAstexViewer
G 726 - 745 Jmol OpenAstexViewer
K 726 - 745 Jmol OpenAstexViewer
4UUK A 726 - 745 Jmol OpenAstexViewer
D 726 - 745 Jmol OpenAstexViewer
G 726 - 745 Jmol OpenAstexViewer
K 726 - 745 Jmol OpenAstexViewer
PH 520 - 624 1DYN A 12 - 116 Jmol OpenAstexViewer
B 12 - 116 Jmol OpenAstexViewer
2DYN A 12 - 116 Jmol OpenAstexViewer
B 12 - 116 Jmol OpenAstexViewer
3SNH A 520 - 624 Jmol OpenAstexViewer
3ZYS C 12 - 116 Jmol OpenAstexViewer
F 12 - 116 Jmol OpenAstexViewer
4UUD C 520 - 624 Jmol OpenAstexViewer
F 520 - 624 Jmol OpenAstexViewer
H 520 - 624 Jmol OpenAstexViewer
L 520 - 624 Jmol OpenAstexViewer
4UUK C 520 - 624 Jmol OpenAstexViewer
F 520 - 624 Jmol OpenAstexViewer
H 520 - 624 Jmol OpenAstexViewer
L 520 - 624 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.