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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RN5A_HUMAN (Q05823)

Summary

This is the summary of UniProt entry RN5A_HUMAN (Q05823).

Description: 2-5A-dependent ribonuclease EC=3.1.26.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 741 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 21
Pfam Ank 58 89
disorder n/a 156 160
disorder n/a 166 169
Pfam Ank 167 200
low_complexity n/a 276 292
disorder n/a 331 333
Pfam Pkinase 368 524
disorder n/a 550 551
disorder n/a 553 554
Pfam Ribonuc_2-5A 592 720
disorder n/a 616 617
disorder n/a 677 678
disorder n/a 713 732
low_complexity n/a 729 740

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q05823. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MESRDHNNPQ EGPTSSSGRR AAVEDNHLLI KAVQNEDVDL VQQLLEGGAN
50
51
VNFQEEEGGW TPLHNAVQMS REDIVELLLR HGADPVLRKK NGATPFILAA
100
101
IAGSVKLLKL FLSKGADVNE CDFYGFTAFM EAAVYGKVKA LKFLYKRGAN
150
151
VNLRRKTKED QERLRKGGAT ALMDAAEKGH VEVLKILLDE MGADVNACDN
200
201
MGRNALIHAL LSSDDSDVEA ITHLLLDHGA DVNVRGERGK TPLILAVEKK
250
251
HLGLVQRLLE QEHIEINDTD SDGKTALLLA VELKLKKIAE LLCKRGASTD
300
301
CGDLVMTARR NYDHSLVKVL LSHGAKEDFH PPAEDWKPQS SHWGAALKDL
350
351
HRIYRPMIGK LKFFIDEKYK IADTSEGGIY LGFYEKQEVA VKTFCEGSPR
400
401
AQREVSCLQS SRENSHLVTF YGSESHRGHL FVCVTLCEQT LEACLDVHRG
450
451
EDVENEEDEF ARNVLSSIFK AVQELHLSCG YTHQDLQPQN ILIDSKKAAH
500
501
LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE DLKAQSNEEV
550
551
VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG
600
601
NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK
650
651
RGNFYQNTVG DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV
700
701
IYVYTKLQNT EYRKHFPQTH SPNKPQCDGA GGASGLASPG C         
741
 

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Checksums:
CRC64:91385EA307E3CE1D
MD5:6f833435658bf73e44d1bd615b3cbd30

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank 167 - 200 1WDY A 167 - 200 Show 3D Structure View in InterPro
4G8K A 167 - 200 Show 3D Structure View in InterPro
B 167 - 200 Show 3D Structure View in InterPro
4G8L B 167 - 200 Show 3D Structure View in InterPro
C 167 - 200 Show 3D Structure View in InterPro
D 167 - 200 Show 3D Structure View in InterPro
4OAU C 167 - 200 Show 3D Structure View in InterPro
4OAV B 167 - 200 Show 3D Structure View in InterPro
D 167 - 200 Show 3D Structure View in InterPro
168 - 200 4G8L A 168 - 200 Show 3D Structure View in InterPro
58 - 89 1WDY A 58 - 89 Show 3D Structure View in InterPro
4G8K A 58 - 89 Show 3D Structure View in InterPro
B 58 - 89 Show 3D Structure View in InterPro
4G8L A 58 - 89 Show 3D Structure View in InterPro
B 58 - 89 Show 3D Structure View in InterPro
C 58 - 89 Show 3D Structure View in InterPro
D 58 - 89 Show 3D Structure View in InterPro
4OAU C 58 - 89 Show 3D Structure View in InterPro
4OAV B 58 - 89 Show 3D Structure View in InterPro
D 58 - 89 Show 3D Structure View in InterPro
Pkinase 368 - 524 4OAU C 368 - 524 Show 3D Structure View in InterPro
4OAV B 368 - 524 Show 3D Structure View in InterPro
D 368 - 524 Show 3D Structure View in InterPro
Ribonuc_2-5A 592 - 717 4OAV B 592 - 717 Show 3D Structure View in InterPro
592 - 719 4OAU C 592 - 719 Show 3D Structure View in InterPro
4OAV D 592 - 719 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;