Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
79  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BTK_HUMAN (Q06187)

Summary

This is the summary of UniProt entry BTK_HUMAN (Q06187).

Description: Tyrosine-protein kinase BTK EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 659 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam PH 4 133
disorder n/a 72 86
low_complexity n/a 83 95
Pfam BTK 141 170
disorder n/a 166 210
low_complexity n/a 182 191
low_complexity n/a 197 209
Pfam SH3_1 220 266
disorder n/a 263 267
Pfam SH2 281 362
disorder n/a 292 293
Pfam PK_Tyr_Ser-Thr 402 651

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q06187. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG
50
51
SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY
100
101
PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG
150
151
QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK
200
201
PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP
250
251
WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK
300
301
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH
350
351
LFSTIPELIN YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK
400
401
DLTFLKELGT GQFGVVKYGK WRGQYDVAIK MIKEGSMSED EFIEEAKVMM
450
451
NLSHEKLVQL YGVCTKQRPI FIITEYMANG CLLNYLREMR HRFQTQQLLE
500
501
MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF GLSRYVLDDE
550
551
YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER
600
601
FTNSETAEHI AQGLRLYRPH LASEKVYTIM YSCWHEKADE RPTFKILLSN
650
651
ILDVMDEES                                             
659
 

Show the unformatted sequence.

Checksums:
CRC64:DF06B5D1FEC257CC
MD5:cdc1eb3031dbbbad38e0ebfbc0fd30bd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BTK 141 - 168 2Z0P A 141 - 168 Jmol OpenAstexViewer
141 - 170 1B55 A 141 - 170 Jmol OpenAstexViewer
B 141 - 170 Jmol OpenAstexViewer
1BTK A 141 - 170 Jmol OpenAstexViewer
B 141 - 170 Jmol OpenAstexViewer
1BWN A 141 - 170 Jmol OpenAstexViewer
B 141 - 170 Jmol OpenAstexViewer
2Z0P B 141 - 170 Jmol OpenAstexViewer
C 141 - 170 Jmol OpenAstexViewer
D 141 - 170 Jmol OpenAstexViewer
PH 4 - 133 1B55 A 4 - 133 Jmol OpenAstexViewer
B 4 - 133 Jmol OpenAstexViewer
1BTK A 4 - 133 Jmol OpenAstexViewer
B 4 - 133 Jmol OpenAstexViewer
1BWN A 4 - 133 Jmol OpenAstexViewer
B 4 - 133 Jmol OpenAstexViewer
2Z0P A 4 - 133 Jmol OpenAstexViewer
B 4 - 133 Jmol OpenAstexViewer
C 4 - 133 Jmol OpenAstexViewer
D 4 - 133 Jmol OpenAstexViewer
PK_Tyr_Ser-Thr 402 - 651 1K2P A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
3GEN A 402 - 651 Jmol OpenAstexViewer
3K54 A 402 - 651 Jmol OpenAstexViewer
3OCS A 402 - 651 Jmol OpenAstexViewer
3OCT A 402 - 651 Jmol OpenAstexViewer
3P08 A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
3PIX A 402 - 651 Jmol OpenAstexViewer
3PIY A 402 - 651 Jmol OpenAstexViewer
3PIZ A 402 - 651 Jmol OpenAstexViewer
3PJ1 A 402 - 651 Jmol OpenAstexViewer
3PJ2 A 402 - 651 Jmol OpenAstexViewer
3PJ3 A 402 - 651 Jmol OpenAstexViewer
4NWM A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
4OT5 A 402 - 651 Jmol OpenAstexViewer
4OT6 A 402 - 651 Jmol OpenAstexViewer
4OTF A 402 - 651 Jmol OpenAstexViewer
4OTQ A 402 - 651 Jmol OpenAstexViewer
4OTR A 402 - 651 Jmol OpenAstexViewer
4RFY A 402 - 651 Jmol OpenAstexViewer
4RFZ A 402 - 651 Jmol OpenAstexViewer
4RG0 A 402 - 651 Jmol OpenAstexViewer
4RX5 A 402 - 651 Jmol OpenAstexViewer
4YHF A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
4Z3V A 402 - 651 Jmol OpenAstexViewer
4ZLY A 402 - 651 Jmol OpenAstexViewer
4ZLZ A 402 - 651 Jmol OpenAstexViewer
5BPY A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
5BQ0 A 402 - 651 Jmol OpenAstexViewer
5FBN C 402 - 651 Jmol OpenAstexViewer
D 402 - 651 Jmol OpenAstexViewer
5FBO A 402 - 651 Jmol OpenAstexViewer
5J87 A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
C 402 - 651 Jmol OpenAstexViewer
D 402 - 651 Jmol OpenAstexViewer
5JRS A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
5KUP A 402 - 651 Jmol OpenAstexViewer
5P9F A 402 - 651 Jmol OpenAstexViewer
5P9G A 402 - 651 Jmol OpenAstexViewer
5P9H A 402 - 651 Jmol OpenAstexViewer
5P9I A 402 - 651 Jmol OpenAstexViewer
5P9J A 402 - 651 Jmol OpenAstexViewer
5P9K A 402 - 651 Jmol OpenAstexViewer
5P9L A 402 - 651 Jmol OpenAstexViewer
5P9M A 402 - 651 Jmol OpenAstexViewer
5T18 A 402 - 651 Jmol OpenAstexViewer
5U9D A 402 - 651 Jmol OpenAstexViewer
5VFI A 402 - 651 Jmol OpenAstexViewer
5VGO A 402 - 651 Jmol OpenAstexViewer
5XYZ A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
5ZZ4 A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
C 402 - 651 Jmol OpenAstexViewer
D 402 - 651 Jmol OpenAstexViewer
E 402 - 651 Jmol OpenAstexViewer
F 402 - 651 Jmol OpenAstexViewer
6AUA A 402 - 651 Jmol OpenAstexViewer
6AUB A 402 - 651 Jmol OpenAstexViewer
6BIK A 402 - 651 Jmol OpenAstexViewer
6BKE A 402 - 651 Jmol OpenAstexViewer
6BKH A 402 - 651 Jmol OpenAstexViewer
6BKW A 402 - 651 Jmol OpenAstexViewer
6BLN A 402 - 651 Jmol OpenAstexViewer
6DI0 A 402 - 651 Jmol OpenAstexViewer
6DI1 A 402 - 651 Jmol OpenAstexViewer
6DI3 A 402 - 651 Jmol OpenAstexViewer
6DI5 A 402 - 651 Jmol OpenAstexViewer
6DI9 A 402 - 651 Jmol OpenAstexViewer
6E4F A 402 - 651 Jmol OpenAstexViewer
6EP9 A 402 - 651 Jmol OpenAstexViewer
6HRP A 402 - 651 Jmol OpenAstexViewer
6HRT A 402 - 651 Jmol OpenAstexViewer
6J6M A 402 - 651 Jmol OpenAstexViewer
6N9P A 402 - 651 Jmol OpenAstexViewer
6NFH A 402 - 651 Jmol OpenAstexViewer
6NFI A 402 - 651 Jmol OpenAstexViewer
6NZM A 402 - 651 Jmol OpenAstexViewer
D 402 - 651 Jmol OpenAstexViewer
6O8I A 402 - 651 Jmol OpenAstexViewer
6OMU A 402 - 651 Jmol OpenAstexViewer
6S90 A 402 - 651 Jmol OpenAstexViewer
B 402 - 651 Jmol OpenAstexViewer
SH2 281 - 362 2GE9 A 12 - 93 Jmol OpenAstexViewer
SH3_1 220 - 266 1AWW A 12 - 58 Jmol OpenAstexViewer
1AWX A 12 - 58 Jmol OpenAstexViewer
1QLY A 5 - 51 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.