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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FMR1_HUMAN (Q06787)

Summary

This is the summary of UniProt entry FMR1_HUMAN (Q06787).

Description: Synaptic functional regulator FMR1 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 632 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Tudor_FRX1 4 52
Pfam Agenet 62 117
Pfam KH_9 123 207
disorder n/a 210 211
Pfam KH_1 220 280
Pfam KH_1 283 333
disorder n/a 318 320
disorder n/a 323 367
disorder n/a 369 371
disorder n/a 376 379
Pfam FXMRP1_C_core 420 542
disorder n/a 435 632
low_complexity n/a 492 504
low_complexity n/a 527 549
Pfam FXMR_C2 549 632

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q06787. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP
50
51
PPVGYNKDIN ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD
100
101
ATYNEIVTIE RLRSVNPNKP ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF
150
151
KKAVGAFSVT YDPENYQLVI LSINEVTSKR AHMLIDMHFR SLRTKLSLIM
200
201
RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN IQQARKVPGV
250
251
TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
300
301
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP
350
351
EEKKHLDIKE NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP
400
401
FVFVGTKDSI ANATVLLDYH LNYLKEVDQL RLERLQIDEQ LRQIGASSRP
450
451
PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG HGRRGPGYTS GTNSEASNAS
500
501
ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG QGGRGRGGGF
550
551
KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
600
601
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP                   
632
 

Show the unformatted sequence.

Checksums:
CRC64:F853D6C82E3489B9
MD5:919200cbc3d1f02aaa43b717b6350ada

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Agenet 62 - 117 2BKD N 62 - 117 Show 3D Structure View in InterPro
4OVA A 62 - 117 Show 3D Structure View in InterPro
B 62 - 117 Show 3D Structure View in InterPro
C 62 - 117 Show 3D Structure View in InterPro
D 62 - 117 Show 3D Structure View in InterPro
4QVZ A 62 - 117 Show 3D Structure View in InterPro
B 62 - 117 Show 3D Structure View in InterPro
4QW2 A 62 - 117 Show 3D Structure View in InterPro
B 62 - 117 Show 3D Structure View in InterPro
FXMRP1_C_core 420 - 425 2QND A 139 - 144 Show 3D Structure View in InterPro
B 139 - 144 Show 3D Structure View in InterPro
427 - 437 5UWJ D 427 - 437 Show 3D Structure View in InterPro
430 - 438 5UWO D 11 - 20 Show 3D Structure View in InterPro
527 - 541 2LA5 B 3 - 17 Show 3D Structure View in InterPro
529 - 542 5DE5 B 5 - 18 Show 3D Structure View in InterPro
5DE8 B 5 - 18 Show 3D Structure View in InterPro
5DEA B 5 - 18 Show 3D Structure View in InterPro
D 5 - 18 Show 3D Structure View in InterPro
530 - 542 5DE5 D 6 - 18 Show 3D Structure View in InterPro
5DE8 D 6 - 18 Show 3D Structure View in InterPro
KH_1 220 - 280 2FMR A 5 - 65 Show 3D Structure View in InterPro
2QND A 5 - 65 Show 3D Structure View in InterPro
B 5 - 65 Show 3D Structure View in InterPro
283 - 330 2QND A 68 - 115 Show 3D Structure View in InterPro
B 68 - 115 Show 3D Structure View in InterPro
KH_9 123 - 134 2BKD N 123 - 134 Show 3D Structure View in InterPro
123 - 199 4OVA C 123 - 199 Show 3D Structure View in InterPro
123 - 200 4OVA A 123 - 200 Show 3D Structure View in InterPro
B 123 - 200 Show 3D Structure View in InterPro
D 123 - 200 Show 3D Structure View in InterPro
123 - 201 4QVZ A 123 - 201 Show 3D Structure View in InterPro
4QW2 A 123 - 201 Show 3D Structure View in InterPro
123 - 202 4QW2 B 123 - 202 Show 3D Structure View in InterPro
123 - 207 4QVZ B 123 - 207 Show 3D Structure View in InterPro
Tudor_FRX1 4 - 52 2BKD N 4 - 52 Show 3D Structure View in InterPro
4OVA A 4 - 52 Show 3D Structure View in InterPro
B 4 - 52 Show 3D Structure View in InterPro
C 4 - 52 Show 3D Structure View in InterPro
D 4 - 52 Show 3D Structure View in InterPro
4QVZ A 4 - 52 Show 3D Structure View in InterPro
B 4 - 52 Show 3D Structure View in InterPro
4QW2 A 4 - 52 Show 3D Structure View in InterPro
B 4 - 52 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;