Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KHDR1_HUMAN (Q07666)

Summary

This is the summary of UniProt entry KHDR1_HUMAN (Q07666).

Description: KH domain-containing, RNA-binding, signal transduction-associated protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 443 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 138
low_complexity n/a 9 20
low_complexity n/a 42 57
low_complexity n/a 57 73
low_complexity n/a 80 93
Pfam Qua1 102 153
disorder n/a 140 148
Pfam KH_1 157 227
disorder n/a 188 189
disorder n/a 198 200
disorder n/a 204 218
disorder n/a 275 276
low_complexity n/a 275 315
disorder n/a 279 321
disorder n/a 323 375
low_complexity n/a 325 350
low_complexity n/a 355 362
low_complexity n/a 363 376
Pfam Sam68-YY 366 415
low_complexity n/a 376 391
disorder n/a 377 440
disorder n/a 442 443

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q07666. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG
50
51
SRGGARASPA TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE
100
101
NKYLPELMAE KDSLDPSFTH AMQLLTAEIE KIQKGDSKKD DEENYLDLFS
150
151
HKNMKLKERV LIPVKQYPKF NFVGKILGPQ GNTIKRLQEE TGAKISVLGK
200
201
GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA YALMAHAMEE
250
251
VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVPVRG RGAAPPPPPV
300
301
PRGRGVGPPR GALVRGTPVR GAITRGATVT RGVPPPPTVR GAPAPRARTA
350
351
GIQRIPLPPP PAPETYEEYG YDDTYAEQSY EGYEGYYSQS QGDSEYYDYG
400
401
HGEVQDSYEA YGQDDWNGTR PSLKAPPARP VKGAYREHPY GRY       
443
 

Show the unformatted sequence.

Checksums:
CRC64:59FB4DB6FB4DBE98
MD5:a4b81aa3d24e0f0fdbc54106446b17bd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Qua1 102 - 135 2XA6 A 102 - 135 Jmol OpenAstexViewer
B 102 - 135 Jmol OpenAstexViewer
Sam68-YY 379 - 388 3QHE B 379 - 388 Jmol OpenAstexViewer
379 - 389 3QHE D 379 - 389 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.