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74  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SOS1_HUMAN (Q07889)

Summary

This is the summary of UniProt entry SOS1_HUMAN (Q07889).

Description: Son of sevenless homolog 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1333 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 72 73
Pfam RhoGEF 210 388
Pfam PH 428 546
disorder n/a 570 574
Pfam RasGEF_N 600 717
low_complexity n/a 644 657
disorder n/a 656 664
disorder n/a 748 751
Pfam RasGEF 783 962
disorder n/a 992 993
disorder n/a 1019 1023
disorder n/a 1025 1110
low_complexity n/a 1079 1093
low_complexity n/a 1103 1116
disorder n/a 1112 1333
low_complexity n/a 1146 1168
low_complexity n/a 1207 1223
low_complexity n/a 1227 1238
low_complexity n/a 1248 1266

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q07889. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE
50
51
LILQLLNMLC QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR
100
101
NPLSLPVEKI HPLLKEVLGY KIDHQVSVYI VAVLEYISAD ILKLVGNYVR
150
151
NIRHYEITKQ DIKVAMCADK VLMDMFHQDV EDINILSLTD EEPSTSGEQT
200
201
YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN DVENIFSRIV
250
251
DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR
300
301
DILRPGFHDR FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC
350
351
LHYFELLKQL EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL
400
401
SESACRFYSQ QMKGKQLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGTL
450
451
TRVGAKHERH IFLFDGLMIC CKSNHGQPRL PGASNAEYRL KEKFFMRKVQ
500
501
INDKDDTNEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA LISLQYRSTL
550
551
ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI
600
601
IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI
650
651
PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH
700
701
FYDFERDAYL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH
750
751
NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ
800
801
PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA
850
851
VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI
900
901
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR
950
951
HGKELINFSK RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS
1000
1001
MEKEFTDYLF NKSLEIEPRN PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM
1050
1051
RHPTPLQQEP RKISYSRIPE SETESTASAP NSPRTPLTPP PASGASSTTD
1100
1101
VCSVFDSDHS SPFHSSNDTV FIQVTLPHGP RSASVSSISL TKGTDEVPVP
1150
1151
PPVPPRRRPE SAPAESSPSK IMSKHLDSPP AIPPRQPTSK AYSPRYSISD
1200
1201
RTSISDPPES PPLLPPREPV RTPDVFSSSP LHLQPPPLGK KSDHGNAFFP
1250
1251
NSPSPFTPPP PQTPSPHGTR RHLPSPPLTQ EVDLHSIAGP PVPPRQSTSQ
1300
1301
HIPKLPPKTY KREHTHPSMH RDGPPLLENA HSS                  
1333
 

Show the unformatted sequence.

Checksums:
CRC64:C6B99CCA11A8DE45
MD5:2b6c54798a6b178e5b71e59a8ac995cd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PH 428 - 546 1AWE A 28 - 146 Show 3D Structure View in InterPro
1DBH A 428 - 546 Show 3D Structure View in InterPro
1XD4 A 428 - 546 Show 3D Structure View in InterPro
B 428 - 546 Show 3D Structure View in InterPro
1XDV A 428 - 546 Show 3D Structure View in InterPro
B 428 - 546 Show 3D Structure View in InterPro
3KSY A 428 - 546 Show 3D Structure View in InterPro
RasGEF 783 - 962 1BKD S 783 - 962 Show 3D Structure View in InterPro
1NVU S 783 - 962 Show 3D Structure View in InterPro
1NVV S 783 - 962 Show 3D Structure View in InterPro
1NVW S 783 - 962 Show 3D Structure View in InterPro
1NVX S 783 - 962 Show 3D Structure View in InterPro
1XD2 C 783 - 962 Show 3D Structure View in InterPro
1XD4 A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
1XDV A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
2II0 A 783 - 962 Show 3D Structure View in InterPro
3KSY A 783 - 962 Show 3D Structure View in InterPro
4NYI S 783 - 962 Show 3D Structure View in InterPro
4NYJ S 783 - 962 Show 3D Structure View in InterPro
4NYM S 783 - 962 Show 3D Structure View in InterPro
4URU S 783 - 962 Show 3D Structure View in InterPro
4URV S 783 - 962 Show 3D Structure View in InterPro
4URW S 783 - 962 Show 3D Structure View in InterPro
4URX S 783 - 962 Show 3D Structure View in InterPro
4URY S 783 - 962 Show 3D Structure View in InterPro
4URZ S 783 - 962 Show 3D Structure View in InterPro
4US0 S 783 - 962 Show 3D Structure View in InterPro
4US1 S 783 - 962 Show 3D Structure View in InterPro
4US2 S 783 - 962 Show 3D Structure View in InterPro
5OVD A 783 - 962 Show 3D Structure View in InterPro
5OVE A 783 - 962 Show 3D Structure View in InterPro
5OVF A 783 - 962 Show 3D Structure View in InterPro
5OVG A 783 - 962 Show 3D Structure View in InterPro
5OVH A 783 - 962 Show 3D Structure View in InterPro
5OVI A 783 - 962 Show 3D Structure View in InterPro
5WFO N 783 - 962 Show 3D Structure View in InterPro
5WFP N 783 - 962 Show 3D Structure View in InterPro
5WFQ N 783 - 962 Show 3D Structure View in InterPro
5WFR N 783 - 962 Show 3D Structure View in InterPro
6BVI B 783 - 962 Show 3D Structure View in InterPro
6BVJ B 783 - 962 Show 3D Structure View in InterPro
6BVK B 783 - 962 Show 3D Structure View in InterPro
6BVL B 783 - 962 Show 3D Structure View in InterPro
6BVM B 783 - 962 Show 3D Structure View in InterPro
6CUO B 783 - 962 Show 3D Structure View in InterPro
6CUP B 783 - 962 Show 3D Structure View in InterPro
6CUR B 783 - 962 Show 3D Structure View in InterPro
6D55 B 783 - 962 Show 3D Structure View in InterPro
6D56 B 783 - 962 Show 3D Structure View in InterPro
6D59 B 783 - 962 Show 3D Structure View in InterPro
6D5E B 783 - 962 Show 3D Structure View in InterPro
6D5G B 783 - 962 Show 3D Structure View in InterPro
6D5H B 783 - 962 Show 3D Structure View in InterPro
6D5J B 783 - 962 Show 3D Structure View in InterPro
6D5L B 783 - 962 Show 3D Structure View in InterPro
6D5M S 783 - 962 Show 3D Structure View in InterPro
6D5V S 783 - 962 Show 3D Structure View in InterPro
6D5W S 783 - 962 Show 3D Structure View in InterPro
6EPL S 783 - 962 Show 3D Structure View in InterPro
6EPM S 783 - 962 Show 3D Structure View in InterPro
6EPN S 783 - 962 Show 3D Structure View in InterPro
6EPO S 783 - 962 Show 3D Structure View in InterPro
6EPP S 783 - 962 Show 3D Structure View in InterPro
6SCM A 783 - 962 Show 3D Structure View in InterPro
6SFR A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
6V94 B 783 - 962 Show 3D Structure View in InterPro
6V9F B 783 - 962 Show 3D Structure View in InterPro
6V9J B 783 - 962 Show 3D Structure View in InterPro
6V9L B 783 - 962 Show 3D Structure View in InterPro
6V9M B 783 - 962 Show 3D Structure View in InterPro
6V9N B 783 - 962 Show 3D Structure View in InterPro
6V9O B 783 - 962 Show 3D Structure View in InterPro
7AVI A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
7AVL A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
7AVS A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
7AVT A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
7AVU A 783 - 962 Show 3D Structure View in InterPro
B 783 - 962 Show 3D Structure View in InterPro
7AVV A 783 - 962 Show 3D Structure View in InterPro
7KFZ B 783 - 962 Show 3D Structure View in InterPro
RasGEF_N 600 - 717 1BKD S 600 - 717 Show 3D Structure View in InterPro
1NVU S 600 - 717 Show 3D Structure View in InterPro
1NVV S 600 - 717 Show 3D Structure View in InterPro
1NVW S 600 - 717 Show 3D Structure View in InterPro
1NVX S 600 - 717 Show 3D Structure View in InterPro
1XD2 C 600 - 717 Show 3D Structure View in InterPro
1XD4 A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
1XDV A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
2II0 A 600 - 717 Show 3D Structure View in InterPro
3KSY A 600 - 717 Show 3D Structure View in InterPro
4NYI S 600 - 717 Show 3D Structure View in InterPro
4NYJ S 600 - 717 Show 3D Structure View in InterPro
4NYM S 600 - 717 Show 3D Structure View in InterPro
4URU S 600 - 717 Show 3D Structure View in InterPro
4URV S 600 - 717 Show 3D Structure View in InterPro
4URW S 600 - 717 Show 3D Structure View in InterPro
4URX S 600 - 717 Show 3D Structure View in InterPro
4URY S 600 - 717 Show 3D Structure View in InterPro
4URZ S 600 - 717 Show 3D Structure View in InterPro
4US0 S 600 - 717 Show 3D Structure View in InterPro
4US1 S 600 - 717 Show 3D Structure View in InterPro
4US2 S 600 - 717 Show 3D Structure View in InterPro
5OVD A 600 - 717 Show 3D Structure View in InterPro
5OVE A 600 - 717 Show 3D Structure View in InterPro
5OVF A 600 - 717 Show 3D Structure View in InterPro
5OVG A 600 - 717 Show 3D Structure View in InterPro
5OVH A 600 - 717 Show 3D Structure View in InterPro
5OVI A 600 - 717 Show 3D Structure View in InterPro
5WFO N 600 - 717 Show 3D Structure View in InterPro
5WFP N 600 - 717 Show 3D Structure View in InterPro
5WFQ N 600 - 717 Show 3D Structure View in InterPro
5WFR N 600 - 717 Show 3D Structure View in InterPro
6BVI B 600 - 717 Show 3D Structure View in InterPro
6BVJ B 600 - 717 Show 3D Structure View in InterPro
6BVK B 600 - 717 Show 3D Structure View in InterPro
6BVL B 600 - 717 Show 3D Structure View in InterPro
6BVM B 600 - 717 Show 3D Structure View in InterPro
6CUO B 600 - 717 Show 3D Structure View in InterPro
6CUP B 600 - 717 Show 3D Structure View in InterPro
6CUR B 600 - 717 Show 3D Structure View in InterPro
6D55 B 600 - 717 Show 3D Structure View in InterPro
6D56 B 600 - 717 Show 3D Structure View in InterPro
6D59 B 600 - 717 Show 3D Structure View in InterPro
6D5E B 600 - 717 Show 3D Structure View in InterPro
6D5G B 600 - 717 Show 3D Structure View in InterPro
6D5H B 600 - 717 Show 3D Structure View in InterPro
6D5J B 600 - 717 Show 3D Structure View in InterPro
6D5L B 600 - 717 Show 3D Structure View in InterPro
6D5M S 600 - 717 Show 3D Structure View in InterPro
6D5V S 600 - 717 Show 3D Structure View in InterPro
6D5W S 600 - 717 Show 3D Structure View in InterPro
6EPL S 600 - 717 Show 3D Structure View in InterPro
6EPM S 600 - 717 Show 3D Structure View in InterPro
6EPN S 600 - 717 Show 3D Structure View in InterPro
6EPO S 600 - 717 Show 3D Structure View in InterPro
6EPP S 600 - 717 Show 3D Structure View in InterPro
6SCM A 600 - 717 Show 3D Structure View in InterPro
6SFR A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
6V94 B 600 - 717 Show 3D Structure View in InterPro
6V9F B 600 - 717 Show 3D Structure View in InterPro
6V9J B 600 - 717 Show 3D Structure View in InterPro
6V9L B 600 - 717 Show 3D Structure View in InterPro
6V9M B 600 - 717 Show 3D Structure View in InterPro
6V9N B 600 - 717 Show 3D Structure View in InterPro
6V9O B 600 - 717 Show 3D Structure View in InterPro
7AVI A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
7AVL A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
7AVS A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
7AVT A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
7AVU A 600 - 717 Show 3D Structure View in InterPro
B 600 - 717 Show 3D Structure View in InterPro
7AVV A 600 - 717 Show 3D Structure View in InterPro
7KFZ B 600 - 717 Show 3D Structure View in InterPro
RhoGEF 210 - 388 1DBH A 210 - 388 Show 3D Structure View in InterPro
1XD4 A 210 - 388 Show 3D Structure View in InterPro
B 210 - 388 Show 3D Structure View in InterPro
1XDV A 210 - 388 Show 3D Structure View in InterPro
B 210 - 388 Show 3D Structure View in InterPro
3KSY A 210 - 388 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;