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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ACK1_HUMAN (Q07912)

Summary

This is the summary of UniProt entry ACK1_HUMAN (Q07912).

Description: Activated CDC42 kinase 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1038 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 9 20
disorder n/a 91 114
low_complexity n/a 102 112
Pfam Pkinase_Tyr 126 385
disorder n/a 346 348
Pfam SH3_9 395 444
disorder n/a 399 400
Pfam GTPase_binding 447 514
disorder n/a 458 466
disorder n/a 473 474
disorder n/a 496 535
low_complexity n/a 532 545
disorder n/a 546 570
disorder n/a 584 585
disorder n/a 593 643
disorder n/a 646 647
disorder n/a 649 654
disorder n/a 656 848
low_complexity n/a 719 732
low_complexity n/a 736 753
low_complexity n/a 769 785
Pfam Inhibitor_Mig-6 774 840
low_complexity n/a 791 810
disorder n/a 855 860
disorder n/a 870 969
low_complexity n/a 880 908
low_complexity n/a 929 943

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q07912. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG
50
51
MGRPGQRRLW EAVKRRKALC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK
100
101
TSPAPGGPAG EGPLQSLTCL IGEKDLRLLE KLGDGSFGVV RRGEWDAPSG
150
151
KTVSVAVKCL KPDVLSQPEA MDDFIREVNA MHSLDHRNLI RLYGVVLTPP
200
201
MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM GYLESKRFIH
250
251
RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE
300
301
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL
350
351
PRPEDCPQDI YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE
400
401
EPDKLHIQMN DVITVIEGRA ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS
450
451
AQDISQPLQN SFIHTGHGDS DPRHCWGFPD RIDELYLGNP MDPPDLLSVE
500
501
LSTSRPPQHL GGVKKPTYDP VSEDQDPLSS DFKRLGLRKP GLPRGLWLAK
550
551
PSARVPGTKA SRGSGAEVTL IDFGEEPVVP ALRPCAPSLA QLAMDACSLL
600
601
DETPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEICSI
650
651
NSTLVGAGVP AGPSQGQTNY AFVPEQARPP PPLEDNLFLP PQGGGKPPSS
700
701
AQTAEIFQAL QQECMRQLQA PAGSPAPSPS PGGDDKPQVP PRVPIPPRPT
750
751
RPHVQLSPAP PGEEETSQWP GPASPPRVPP REPLSPQGSR TPSPLVPPGS
800
801
SPLPPRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA GPCILPIVRD
850
851
GKKVSSTHYY LLPERPSYLE RYQRFLREAQ SPEEPTPLPV PLLLPPPSTP
900
901
APAAPTATVR PMPQAALDPK ANFSTNNSNP GARPPPPRAT ARLPQRGCPG
950
951
DGPEAGRPAD KIQMAMVHGV TTEECQAALQ CHGWSVQRAA QYLKVEQLFG
1000
1001
LGLRPRGECH KVLEMFDWNL EQAGCHLLGS WGPAHHKR             
1038
 

Show the unformatted sequence.

Checksums:
CRC64:74A1980665BC3E6B
MD5:1e6544f1539195eeda77573e594ae6bf

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
GTPase_binding 447 - 489 1CF4 B 503 - 545 Jmol OpenAstexViewer
Pkinase_Tyr 126 - 385 1U46 A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
1U4D A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
1U54 A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
3EQP A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
3EQR A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
4EWH A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
4HZR A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
4HZS A 126 - 385 Jmol OpenAstexViewer
B 126 - 385 Jmol OpenAstexViewer
C 126 - 385 Jmol OpenAstexViewer
D 126 - 385 Jmol OpenAstexViewer
4ID7 A 126 - 385 Jmol OpenAstexViewer
SH3_9 395 - 444 4HZS A 395 - 444 Jmol OpenAstexViewer
B 395 - 444 Jmol OpenAstexViewer
C 395 - 444 Jmol OpenAstexViewer
D 395 - 444 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.