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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TGM3_HUMAN (Q08188)

Summary

This is the summary of UniProt entry TGM3_HUMAN (Q08188).

Description: Protein-glutamine gamma-glutamyltransferase E
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 693 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Transglut_N 3 118
low_complexity n/a 97 107
Pfam Transglut_core 240 355
disorder n/a 438 441
disorder n/a 453 454
disorder n/a 468 472
Pfam Transglut_C 483 588
low_complexity n/a 496 507
disorder n/a 541 543
Pfam Transglut_C 595 693

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q08188. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS
50
51
NERLEFIVST GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI
100
101
SSPASAPIGR YTMALQIFSQ GGISSVKLGT FILLFNPWLN VDSVFMGNHA
150
151
EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ FEEDILSICL SILDRSLNFR
200
201
RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT YTGGRDPRSW
250
251
NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA
300
301
HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW
350
351
QVLDATPQER SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW
400
401
LYDNTTGKQW KNSVNSHTIG RYISTKAVGS NARMDVTDKY KYPEGSDQER
450
451
QVFQKALGKL KPNTPFAATS SMGLETEEQE PSIIGKLKVA GMLAVGKEVN
500
501
LVLLLKNLSR DTKTVTVNMT AWTIIYNGTL VHEVWKDSAT MSLDPEEEAE
550
551
HPIKISYAQY EKYLKSDNMI RITAVCKVPD ESEVVVERDI ILDNPTLTLE
600
601
VLNEARVRKP VNVQMLFSNP LDEPVRDCVL MVEGSGLLLG NLKIDVPTLG
650
651
PKEGSRVRFD ILPSRSGTKQ LLADFSCNKF PAIKAMLSID VAE       
693
 

Show the unformatted sequence.

Checksums:
CRC64:EAFAC0C9A8AA5FD6
MD5:399bfeda67b0a105b55d76b6fb8a78a6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Transglut_C 483 - 588 1L9M A 482 - 587 Jmol OpenAstexViewer
B 482 - 587 Jmol OpenAstexViewer
1L9N A 482 - 587 Jmol OpenAstexViewer
B 482 - 587 Jmol OpenAstexViewer
1NUD A 482 - 587 Jmol OpenAstexViewer
B 482 - 587 Jmol OpenAstexViewer
1NUF A 482 - 587 Jmol OpenAstexViewer
1NUG A 482 - 587 Jmol OpenAstexViewer
B 482 - 587 Jmol OpenAstexViewer
595 - 693 1L9M A 594 - 692 Jmol OpenAstexViewer
B 594 - 692 Jmol OpenAstexViewer
1L9N A 594 - 692 Jmol OpenAstexViewer
B 594 - 692 Jmol OpenAstexViewer
1NUD A 594 - 692 Jmol OpenAstexViewer
B 594 - 692 Jmol OpenAstexViewer
1NUF A 594 - 692 Jmol OpenAstexViewer
1NUG A 594 - 692 Jmol OpenAstexViewer
B 594 - 692 Jmol OpenAstexViewer
Transglut_core 240 - 355 1L9M A 239 - 354 Jmol OpenAstexViewer
B 239 - 354 Jmol OpenAstexViewer
1L9N A 239 - 354 Jmol OpenAstexViewer
B 239 - 354 Jmol OpenAstexViewer
1NUD A 239 - 354 Jmol OpenAstexViewer
B 239 - 354 Jmol OpenAstexViewer
1NUF A 239 - 354 Jmol OpenAstexViewer
1NUG A 239 - 354 Jmol OpenAstexViewer
B 239 - 354 Jmol OpenAstexViewer
Transglut_N 3 - 118 1L9M A 2 - 117 Jmol OpenAstexViewer
B 2 - 117 Jmol OpenAstexViewer
1L9N A 2 - 117 Jmol OpenAstexViewer
B 2 - 117 Jmol OpenAstexViewer
1NUD A 2 - 117 Jmol OpenAstexViewer
B 2 - 117 Jmol OpenAstexViewer
1NUF A 2 - 117 Jmol OpenAstexViewer
1NUG A 2 - 117 Jmol OpenAstexViewer
B 2 - 117 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.