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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: I10R2_HUMAN (Q08334)

Summary

This is the summary of UniProt entry I10R2_HUMAN (Q08334).

Description: Interleukin-10 receptor subunit beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 325 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
Pfam Tissue_fac 2 100
low_complexity n/a 2 13
Pfam Interfer-bind 111 213
disorder n/a 205 209
transmembrane n/a 221 249
disorder n/a 307 325

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q08334. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL
50
51
TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW
100
101
VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN
150
151
SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK
200
201
AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK
250
251
KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE
300
301
DSESGKQNPG DSCSLGTPPG QGPQS                           
325
 

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Checksums:
CRC64:E470726619AF54C2
MD5:f205123c6fa123752250dfc5e5e27cf6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Interfer-bind 111 - 213 3LQM A 111 - 213 Jmol OpenAstexViewer
B 111 - 213 Jmol OpenAstexViewer
5T5W A 111 - 213 Jmol OpenAstexViewer
Tissue_fac 20 - 100 3LQM A 20 - 100 Jmol OpenAstexViewer
B 20 - 100 Jmol OpenAstexViewer
5T5W A 20 - 100 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.