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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NCBP1_HUMAN (Q09161)

Summary

This is the summary of UniProt entry NCBP1_HUMAN (Q09161).

Description: Nuclear cap-binding protein subunit 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 790 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 25
Pfam MIF4G 28 240
disorder n/a 305 306
Pfam MIF4G_like 308 471
Pfam MIF4G_like_2 485 760
low_complexity n/a 530 534
coiled_coil n/a 645 676
low_complexity n/a 657 667
disorder n/a 666 683
low_complexity n/a 671 685
coiled_coil n/a 685 712
low_complexity n/a 747 760

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q09161. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRRRHSDEN DGGQPHKRRK TSDANETEDH LESLICKVGE KSACSLESNL
50
51
EGLAGVLEAD LPNYKSKILR LLCTVARLLP EKLTIYTTLV GLLNARNYNF
100
101
GGEFVEAMIR QLKESLKANN YNEAVYLVRF LSDLVNCHVI AAPSMVAMFE
150
151
NFVSVTQEED VPQVRRDWYV YAFLSSLPWV GKELYEKKDA EMDRIFANTE
200
201
SYLKRRQKTH VPMLQVWTAD KPHPQEEYLD CLWAQIQKLK KDRWQERHIL
250
251
RPYLAFDSIL CEALQHNLPP FTPPPHTEDS VYPMPRVIFR MFDYTDDPEG
300
301
PVMPGSHSVE RFVIEENLHC IIKSHWKERK TCAAQLVSYP GKNKIPLNYH
350
351
IVEVIFAELF QLPAPPHIDV MYTTLLIELC KLQPGSLPQV LAQATEMLYM
400
401
RLDTMNTTCV DRFINWFSHH LSNFQFRWSW EDWSDCLSQD PESPKPKFVR
450
451
EVLEKCMRLS YHQRILDIVP PTFSALCPAN PTCIYKYGDE SSNSLPGHSV
500
501
ALCLAVAFKS KATNDEIFSI LKDVPNPNQD DDDDEGFSFN PLKIEVFVQT
550
551
LLHLAAKSFS HSFSALAKFH EVFKTLAESD EGKLHVLRVM FEVWRNHPQM
600
601
IAVLVDKMIR TQIVDCAAVA NWIFSSELSR DFTRLFVWEI LHSTIRKMNK
650
651
HVLKIQKELE EAKEKLARQH KRRSDDDDRS SDRKDGVLEE QIERLQEKVE
700
701
SAQSEQKNLF LVIFQRFIMI LTEHLVRCET DGTSVLTPWY KNCIERLQQI
750
751
FLQHHQIIQQ YMVTLENLLF TAELDPHILA VFQQFCALQA           
790
 

Show the unformatted sequence.

Checksums:
CRC64:F10DE7B9D16FDA0B
MD5:b6f5ce6b351355f88e2478cab29e3ffc

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MIF4G 28 - 240 1H2U A 28 - 240 Show 3D Structure View in InterPro
B 28 - 240 Show 3D Structure View in InterPro
1H6K A 28 - 240 Show 3D Structure View in InterPro
B 28 - 240 Show 3D Structure View in InterPro
C 28 - 240 Show 3D Structure View in InterPro
1N52 A 28 - 240 Show 3D Structure View in InterPro
1N54 A 28 - 240 Show 3D Structure View in InterPro
3FEX A 28 - 240 Show 3D Structure View in InterPro
3FEY A 28 - 240 Show 3D Structure View in InterPro
5OO6 A 28 - 240 Show 3D Structure View in InterPro
D 28 - 240 Show 3D Structure View in InterPro
G 28 - 240 Show 3D Structure View in InterPro
J 28 - 240 Show 3D Structure View in InterPro
M 28 - 240 Show 3D Structure View in InterPro
P 28 - 240 Show 3D Structure View in InterPro
S 28 - 240 Show 3D Structure View in InterPro
V 28 - 240 Show 3D Structure View in InterPro
5OOB A 28 - 240 Show 3D Structure View in InterPro
C 28 - 240 Show 3D Structure View in InterPro
F 28 - 240 Show 3D Structure View in InterPro
I 28 - 240 Show 3D Structure View in InterPro
6D0Y C 28 - 240 Show 3D Structure View in InterPro
7ABG A5 28 - 240 Show 3D Structure View in InterPro
29 - 240 1H2T C 29 - 240 Show 3D Structure View in InterPro
1H2V C 29 - 240 Show 3D Structure View in InterPro
MIF4G_like 308 - 471 1H2T C 308 - 471 Show 3D Structure View in InterPro
1H2U A 308 - 471 Show 3D Structure View in InterPro
B 308 - 471 Show 3D Structure View in InterPro
1H2V C 308 - 471 Show 3D Structure View in InterPro
1H6K A 308 - 471 Show 3D Structure View in InterPro
B 308 - 471 Show 3D Structure View in InterPro
C 308 - 471 Show 3D Structure View in InterPro
1N52 A 308 - 471 Show 3D Structure View in InterPro
1N54 A 308 - 471 Show 3D Structure View in InterPro
3FEX A 308 - 471 Show 3D Structure View in InterPro
3FEY A 308 - 471 Show 3D Structure View in InterPro
5OO6 A 308 - 471 Show 3D Structure View in InterPro
D 308 - 471 Show 3D Structure View in InterPro
G 308 - 471 Show 3D Structure View in InterPro
J 308 - 471 Show 3D Structure View in InterPro
M 308 - 471 Show 3D Structure View in InterPro
P 308 - 471 Show 3D Structure View in InterPro
S 308 - 471 Show 3D Structure View in InterPro
V 308 - 471 Show 3D Structure View in InterPro
5OOB A 308 - 471 Show 3D Structure View in InterPro
C 308 - 471 Show 3D Structure View in InterPro
F 308 - 471 Show 3D Structure View in InterPro
I 308 - 471 Show 3D Structure View in InterPro
6D0Y C 308 - 471 Show 3D Structure View in InterPro
7ABG A5 308 - 471 Show 3D Structure View in InterPro
MIF4G_like_2 485 - 760 1H2T C 485 - 760 Show 3D Structure View in InterPro
1H2U A 485 - 760 Show 3D Structure View in InterPro
B 485 - 760 Show 3D Structure View in InterPro
1H2V C 485 - 760 Show 3D Structure View in InterPro
1H6K A 485 - 760 Show 3D Structure View in InterPro
B 485 - 760 Show 3D Structure View in InterPro
C 485 - 760 Show 3D Structure View in InterPro
1N52 A 485 - 760 Show 3D Structure View in InterPro
1N54 A 485 - 760 Show 3D Structure View in InterPro
3FEX A 485 - 760 Show 3D Structure View in InterPro
3FEY A 485 - 760 Show 3D Structure View in InterPro
5OO6 A 485 - 760 Show 3D Structure View in InterPro
D 485 - 760 Show 3D Structure View in InterPro
G 485 - 760 Show 3D Structure View in InterPro
J 485 - 760 Show 3D Structure View in InterPro
M 485 - 760 Show 3D Structure View in InterPro
P 485 - 760 Show 3D Structure View in InterPro
S 485 - 760 Show 3D Structure View in InterPro
V 485 - 760 Show 3D Structure View in InterPro
5OOB A 485 - 760 Show 3D Structure View in InterPro
C 485 - 760 Show 3D Structure View in InterPro
I 485 - 760 Show 3D Structure View in InterPro
6D0Y C 485 - 760 Show 3D Structure View in InterPro
7ABG A5 485 - 760 Show 3D Structure View in InterPro
498 - 760 5OOB F 498 - 760 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;