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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ABCC8_HUMAN (Q09428)

Summary

This is the summary of UniProt entry ABCC8_HUMAN (Q09428).

Description: ATP-binding cassette sub-family C member 8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1581 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
transmembrane n/a 33 52
low_complexity n/a 37 48
transmembrane n/a 73 94
transmembrane n/a 106 124
transmembrane n/a 136 155
transmembrane n/a 161 185
low_complexity n/a 170 184
Pfam ABC_membrane 299 590
transmembrane n/a 307 324
low_complexity n/a 350 367
transmembrane n/a 351 368
transmembrane n/a 430 454
low_complexity n/a 444 457
low_complexity n/a 459 470
transmembrane n/a 460 478
transmembrane n/a 536 559
transmembrane n/a 571 593
disorder n/a 622 632
Pfam ABC_tran 696 857
disorder n/a 744 763
disorder n/a 824 827
disorder n/a 935 936
disorder n/a 938 985
coiled_coil n/a 962 982
low_complexity n/a 968 980
transmembrane n/a 1000 1021
low_complexity n/a 1003 1020
Pfam ABC_membrane 1012 1294
transmembrane n/a 1062 1088
transmembrane n/a 1100 1121
transmembrane n/a 1152 1177
low_complexity n/a 1186 1199
transmembrane n/a 1253 1271
transmembrane n/a 1277 1296
Pfam ABC_tran 1361 1509

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q09428. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLAFCGSEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG
50
51
WGSQSSKVHI HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE
100
101
SHHLHLYMPA GMAFMAAVTS VVYYHNIETS NFPKLLIALL VYWTLAFITK
150
151
TIKFVKFLDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYIFFKT
200
201
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI
250
251
GKLPIAMRAL TNYQRLCEAF DAQVRKDIQG TQGARAIWQA LSHAFGRRLV
300
301
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NDVFQPKTQF LGVYFVSSQE
350
351
FLANAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM
400
401
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI
450
451
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN
500
501
EMLRGIKLLK LYAWENIFRT RVETTRRKEM TSLRAFAIYT SISIFMNTAI
550
551
PIAAVLITFV GHVSFFKEAD FSPSVAFASL SLFHILVTPL FLLSSVVRST
600
601
VKALVSVQKL SEFLSSAEIR EEQCAPHEPT PQGPASKYQA VPLRVVNRKR
650
651
PAREDCRGLT GPLQSLVPSA DGDADNCCVQ IMGGYFTWTP DGIPTLSNIT
700
701
IRIPRGQLTM IVGQVGCGKS SLLLAALGEM QKVSGAVFWS SLPDSEIGED
750
751
PSPERETATD LDIRKRGPVA YASQKPWLLN ATVEENIIFE SPFNKQRYKM
800
801
VIEACSLQPD IDILPHGDQT QIGERGINLS GGQRQRISVA RALYQHANVV
850
851
FLDDPFSALD IHLSDHLMQA GILELLRDDK RTVVLVTHKL QYLPHADWII
900
901
AMKDGTIQRE GTLKDFQRSE CQLFEHWKTL MNRQDQELEK ETVTERKATE
950
951
PPQGLSRAMS SRDGLLQDEE EEEEEAAESE EDDNLSSMLH QRAEIPWRAC
1000
1001
AKYLSSAGIL LLSLLVFSQL LKHMVLVAID YWLAKWTDSA LTLTPAARNC
1050
1051
SLSQECTLDQ TVYAMVFTVL CSLGIVLCLV TSVTVEWTGL KVAKRLHRSL
1100
1101
LNRIILAPMR FFETTPLGSI LNRFSSDCNT IDQHIPSTLE CLSRSTLLCV
1150
1151
SALAVISYVT PVFLVALLPL AIVCYFIQKY FRVASRDLQQ LDDTTQLPLL
1200
1201
SHFAETVEGL TTIRAFRYEA RFQQKLLEYT DSNNIASLFL TAANRWLEVR
1250
1251
MEYIGACVVL IAAVTSISNS LHRELSAGLV GLGLTYALMV SNYLNWMVRN
1300
1301
LADMELQLGA VKRIHGLLKT EAESYEGLLA PSLIPKNWPD QGKIQIQNLS
1350
1351
VRYDSSLKPV LKHVNALIAP GQKIGICGRT GSGKSSFSLA FFRMVDTFEG
1400
1401
HIIIDGIDIA KLPLHTLRSR LSIILQDPVL FSGTIRFNLD PERKCSDSTL
1450
1451
WEALEIAQLK LVVKALPGGL DAIITEGGEN FSQGQRQLFC LARAFVRKTS
1500
1501
IFIMDEATAS IDMATENILQ KVVMTAFADR TVVTIAHRVH TILSADLVIV
1550
1551
LKRGAILEFD KPEKLLSRKD SVFASFVRAD K                    
1581
 

Show the unformatted sequence.

Checksums:
CRC64:09CF2EC97899D1CE
MD5:05012e96e983a24fd3b5fafe1aa406a4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ABC_membrane 1012 - 1294 6C3O E 1012 - 1294 Jmol OpenAstexViewer
F 1012 - 1294 Jmol OpenAstexViewer
G 1012 - 1294 Jmol OpenAstexViewer
H 1012 - 1294 Jmol OpenAstexViewer
6C3P E 1012 - 1294 Jmol OpenAstexViewer
F 1012 - 1294 Jmol OpenAstexViewer
G 1012 - 1294 Jmol OpenAstexViewer
H 1012 - 1294 Jmol OpenAstexViewer
299 - 590 6C3O E 299 - 590 Jmol OpenAstexViewer
F 299 - 590 Jmol OpenAstexViewer
G 299 - 590 Jmol OpenAstexViewer
H 299 - 590 Jmol OpenAstexViewer
6C3P E 299 - 590 Jmol OpenAstexViewer
F 299 - 590 Jmol OpenAstexViewer
G 299 - 590 Jmol OpenAstexViewer
H 299 - 590 Jmol OpenAstexViewer
ABC_tran 1361 - 1509 6C3O E 1361 - 1509 Jmol OpenAstexViewer
F 1361 - 1509 Jmol OpenAstexViewer
G 1361 - 1509 Jmol OpenAstexViewer
H 1361 - 1509 Jmol OpenAstexViewer
6C3P E 1361 - 1509 Jmol OpenAstexViewer
F 1361 - 1509 Jmol OpenAstexViewer
G 1361 - 1509 Jmol OpenAstexViewer
H 1361 - 1509 Jmol OpenAstexViewer
696 - 857 6C3O E 696 - 857 Jmol OpenAstexViewer
F 696 - 857 Jmol OpenAstexViewer
G 696 - 857 Jmol OpenAstexViewer
H 696 - 857 Jmol OpenAstexViewer
6C3P E 696 - 857 Jmol OpenAstexViewer
F 696 - 857 Jmol OpenAstexViewer
G 696 - 857 Jmol OpenAstexViewer
H 696 - 857 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.