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23  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EP300_HUMAN (Q09472)

Summary

This is the summary of UniProt entry EP300_HUMAN (Q09472).

Description: Histone acetyltransferase p300
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2414 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 27
low_complexity n/a 17 27
disorder n/a 29 31
disorder n/a 33 42
disorder n/a 44 272
low_complexity n/a 160 176
disorder n/a 275 276
disorder n/a 280 334
low_complexity n/a 294 308
low_complexity n/a 303 312
Pfam zf-TAZ 338 414
disorder n/a 338 339
disorder n/a 362 363
disorder n/a 417 418
disorder n/a 422 459
disorder n/a 473 476
disorder n/a 478 525
low_complexity n/a 480 500
disorder n/a 527 576
Pfam KIX 566 646
disorder n/a 578 579
disorder n/a 584 588
disorder n/a 590 599
disorder n/a 602 607
disorder n/a 616 617
disorder n/a 642 1052
low_complexity n/a 668 681
low_complexity n/a 830 847
low_complexity n/a 850 876
low_complexity n/a 879 905
low_complexity n/a 897 922
low_complexity n/a 917 943
low_complexity n/a 1007 1021
coiled_coil n/a 1009 1029
low_complexity n/a 1028 1040
Pfam Bromodomain 1058 1144
disorder n/a 1060 1063
disorder n/a 1069 1071
disorder n/a 1076 1078
Pfam DUF902 1156 1195
disorder n/a 1216 1221
disorder n/a 1223 1232
Pfam HAT_KAT11 1306 1612
low_complexity n/a 1512 1535
coiled_coil n/a 1513 1540
disorder n/a 1519 1583
low_complexity n/a 1544 1561
low_complexity n/a 1608 1622
Pfam ZZ 1664 1705
disorder n/a 1707 1710
disorder n/a 1719 1726
Pfam zf-TAZ 1735 1806
low_complexity n/a 1810 1836
disorder n/a 1817 2073
low_complexity n/a 1847 1884
low_complexity n/a 1900 1925
low_complexity n/a 1955 1971
low_complexity n/a 1989 2008
Pfam Creb_binding 1992 2098
low_complexity n/a 2053 2064
low_complexity n/a 2057 2073
disorder n/a 2084 2414
low_complexity n/a 2096 2122
low_complexity n/a 2144 2156
low_complexity n/a 2185 2194
low_complexity n/a 2209 2224
low_complexity n/a 2221 2243
low_complexity n/a 2256 2267
low_complexity n/a 2305 2338
low_complexity n/a 2331 2348
low_complexity n/a 2390 2411

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q09472. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS
50
51
TELGLTNGGD INQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP
100
101
GQVMASQAQQ SSPGLGLINS MVKSPMTQAG LTSPNMGMGT SGPNQGPTQS
150
151
TGMMNSPVNQ PAMGMNTGMN AGMNPGMLAA GNGQGIMPNQ VMNGSIGAGR
200
201
GRQNMQYPNP GMGSAGNLLT EPLQQGSPQM GGQTGLRGPQ PLKMGMMNNP
250
251
NPYGSPYTQN PGQQIGASGL GLQIQTKTVL SNNLSPFAMD KKAVPGGGMP
300
301
NMGQQPAPQV QQPGLVTPVA QGMGSGAHTA DPEKRKLIQQ QLVLLLHAHK
350
351
CQRREQANGE VRQCNLPHCR TMKNVLNHMT HCQSGKSCQV AHCASSRQII
400
401
SHWKNCTRHD CPVCLPLKNA GDKRNQQPIL TGAPVGLGNP SSLGVGQQSA
450
451
PNLSTVSQID PSSIERAYAA LGLPYQVNQM PTQPQVQAKN QQNQQPGQSP
500
501
QGMRPMSNMS ASPMGVNGGV GVQTPSLLSD SMLHSAINSQ NPMMSENASV
550
551
PSLGPMPTAA QPSTTGIRKQ WHEDITQDLR NHLVHKLVQA IFPTPDPAAL
600
601
KDRRMENLVA YARKVEGDMY ESANNRAEYY HLLAEKIYKI QKELEEKRRT
650
651
RLQKQNMLPN AAGMVPVSMN PGPNMGQPQP GMTSNGPLPD PSMIRGSVPN
700
701
QMMPRITPQS GLNQFGQMSM AQPPIVPRQT PPLQHHGQLA QPGALNPPMG
750
751
YGPRMQQPSN QGQFLPQTQF PSQGMNVTNI PLAPSSGQAP VSQAQMSSSS
800
801
CPVNSPIMPP GSQGSHIHCP QLPQPALHQN SPSPVPSRTP TPHHTPPSIG
850
851
AQQPPATTIP APVPTPPAMP PGPQSQALHP PPRQTPTPPT TQLPQQVQPS
900
901
LPAAPSADQP QQQPRSQQST AASVPTPTAP LLPPQPATPL SQPAVSIEGQ
950
951
VSNPPSTSST EVNSQAIAEK QPSQEVKMEA KMEVDQPEPA DTQPEDISES
1000
1001
KVEDCKMEST ETEERSTELK TEIKEEEDQP STSATQSSPA PGQSKKKIFK
1050
1051
PEELRQALMP TLEALYRQDP ESLPFRQPVD PQLLGIPDYF DIVKSPMDLS
1100
1101
TIKRKLDTGQ YQEPWQYVDD IWLMFNNAWL YNRKTSRVYK YCSKLSEVFE
1150
1151
QEIDPVMQSL GYCCGRKLEF SPQTLCCYGK QLCTIPRDAT YYSYQNRYHF
1200
1201
CEKCFNEIQG ESVSLGDDPS QPQTTINKEQ FSKRKNDTLD PELFVECTEC
1250
1251
GRKMHQICVL HHEIIWPAGF VCDGCLKKSA RTRKENKFSA KRLPSTRLGT
1300
1301
FLENRVNDFL RRQNHPESGE VTVRVVHASD KTVEVKPGMK ARFVDSGEMA
1350
1351
ESFPYRTKAL FAFEEIDGVD LCFFGMHVQE YGSDCPPPNQ RRVYISYLDS
1400
1401
VHFFRPKCLR TAVYHEILIG YLEYVKKLGY TTGHIWACPP SEGDDYIFHC
1450
1451
HPPDQKIPKP KRLQEWYKKM LDKAVSERIV HDYKDIFKQA TEDRLTSAKE
1500
1501
LPYFEGDFWP NVLEESIKEL EQEEEERKRE ENTSNESTDV TKGDSKNAKK
1550
1551
KNNKKTSKNK SSLSRGNKKK PGMPNVSNDL SQKLYATMEK HKEVFFVIRL
1600
1601
IAGPAANSLP PIVDPDPLIP CDLMDGRDAF LTLARDKHLE FSSLRRAQWS
1650
1651
TMCMLVELHT QSQDRFVYTC NECKHHVETR WHCTVCEDYD LCITCYNTKN
1700
1701
HDHKMEKLGL GLDDESNNQQ AAATQSPGDS RRLSIQRCIQ SLVHACQCRN
1750
1751
ANCSLPSCQK MKRVVQHTKG CKRKTNGGCP ICKQLIALCC YHAKHCQENK
1800
1801
CPVPFCLNIK QKLRQQQLQH RLQQAQMLRR RMASMQRTGV VGQQQGLPSP
1850
1851
TPATPTTPTG QQPTTPQTPQ PTSQPQPTPP NSMPPYLPRT QAAGPVSQGK
1900
1901
AAGQVTPPTP PQTAQPPLPG PPPAAVEMAM QIQRAAETQR QMAHVQIFQR
1950
1951
PIQHQMPPMT PMAPMGMNPP PMTRGPSGHL EPGMGPTGMQ QQPPWSQGGL
2000
2001
PQPQQLQSGM PRPAMMSVAQ HGQPLNMAPQ PGLGQVGISP LKPGTVSQQA
2050
2051
LQNLLRTLRS PSSPLQQQQV LSILHANPQL LAAFIKQRAA KYANSNPQPI
2100
2101
PGQPGMPQGQ PGLQPPTMPG QQGVHSNPAM QNMNPMQAGV QRAGLPQQQP
2150
2151
QQQLQPPMGG MSPQAQQMNM NHNTMPSQFR DILRRQQMMQ QQQQQGAGPG
2200
2201
IGPGMANHNQ FQQPQGVGYP PQQQQRMQHH MQQMQQGNMG QIGQLPQALG
2250
2251
AEAGASLQAY QQRLLQQQMG SPVQPNPMSP QQHMLPNQAQ SPHLQGQQIP
2300
2301
NSLSNQVRSP QPVPSPRPQS QPPHSSPSPR MQPQPSPHHV SPQTSSPHPG
2350
2351
LVAAQANPME QGHFASPDQN SMLSQLASNP GMANLHGASA TDLGLSTDNS
2400
2401
DLNSNLSQST LDIH                                       
2414
 

Show the unformatted sequence.

Checksums:
CRC64:8E869E1F174A6FEB
MD5:0e71c4fd26c809785655f6adc9a2b50a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Bromodomain 1058 - 1142 5LKT A 1058 - 1142 Jmol OpenAstexViewer
5LKU A 1058 - 1142 Jmol OpenAstexViewer
5LKX A 1058 - 1142 Jmol OpenAstexViewer
5LKZ A 1058 - 1142 Jmol OpenAstexViewer
1058 - 1144 3I3J A 1058 - 1144 Jmol OpenAstexViewer
B 1058 - 1144 Jmol OpenAstexViewer
C 1058 - 1144 Jmol OpenAstexViewer
D 1058 - 1144 Jmol OpenAstexViewer
E 1058 - 1144 Jmol OpenAstexViewer
F 1058 - 1144 Jmol OpenAstexViewer
G 1058 - 1144 Jmol OpenAstexViewer
H 1058 - 1144 Jmol OpenAstexViewer
I 1058 - 1144 Jmol OpenAstexViewer
J 1058 - 1144 Jmol OpenAstexViewer
K 1058 - 1144 Jmol OpenAstexViewer
L 1058 - 1144 Jmol OpenAstexViewer
4BHW A 1058 - 1144 Jmol OpenAstexViewer
B 1058 - 1144 Jmol OpenAstexViewer
5BT3 A 1058 - 1144 Jmol OpenAstexViewer
5LPK A 1058 - 1144 Jmol OpenAstexViewer
B 1058 - 1144 Jmol OpenAstexViewer
C 1058 - 1144 Jmol OpenAstexViewer
D 1058 - 1144 Jmol OpenAstexViewer
E 1058 - 1144 Jmol OpenAstexViewer
F 1058 - 1144 Jmol OpenAstexViewer
G 1058 - 1144 Jmol OpenAstexViewer
5LPM A 1058 - 1144 Jmol OpenAstexViewer
B 1058 - 1144 Jmol OpenAstexViewer
5NU5 A 1058 - 1144 Jmol OpenAstexViewer
B 1058 - 1144 Jmol OpenAstexViewer
DUF902 1156 - 1159 3I3J F 1156 - 1159 Jmol OpenAstexViewer
5LPK E 1156 - 1159 Jmol OpenAstexViewer
1156 - 1160 3I3J A 1156 - 1160 Jmol OpenAstexViewer
C 1156 - 1160 Jmol OpenAstexViewer
D 1156 - 1160 Jmol OpenAstexViewer
G 1156 - 1160 Jmol OpenAstexViewer
H 1156 - 1160 Jmol OpenAstexViewer
J 1156 - 1160 Jmol OpenAstexViewer
K 1156 - 1160 Jmol OpenAstexViewer
L 1156 - 1160 Jmol OpenAstexViewer
5LPK B 1156 - 1160 Jmol OpenAstexViewer
G 1156 - 1160 Jmol OpenAstexViewer
1156 - 1161 3I3J B 1156 - 1161 Jmol OpenAstexViewer
E 1156 - 1161 Jmol OpenAstexViewer
I 1156 - 1161 Jmol OpenAstexViewer
5BT3 A 1156 - 1161 Jmol OpenAstexViewer
5LPK A 1156 - 1161 Jmol OpenAstexViewer
C 1156 - 1161 Jmol OpenAstexViewer
D 1156 - 1161 Jmol OpenAstexViewer
F 1156 - 1161 Jmol OpenAstexViewer
5LPM A 1156 - 1161 Jmol OpenAstexViewer
B 1156 - 1161 Jmol OpenAstexViewer
5NU5 A 1156 - 1161 Jmol OpenAstexViewer
B 1156 - 1161 Jmol OpenAstexViewer
1156 - 1195 4BHW A 1156 - 1195 Jmol OpenAstexViewer
B 1156 - 1195 Jmol OpenAstexViewer
1158 - 1195 5LKT A 1082 - 1112 Jmol OpenAstexViewer
5LKU A 1082 - 1112 Jmol OpenAstexViewer
5LKX A 1082 - 1112 Jmol OpenAstexViewer
5LKZ A 1082 - 1112 Jmol OpenAstexViewer
HAT_KAT11 1306 - 1612 3BIY A 1306 - 1612 Jmol OpenAstexViewer
4BHW A 1306 - 1612 Jmol OpenAstexViewer
B 1306 - 1612 Jmol OpenAstexViewer
4PZR A 1306 - 1612 Jmol OpenAstexViewer
4PZS A 1306 - 1612 Jmol OpenAstexViewer
4PZT A 1306 - 1612 Jmol OpenAstexViewer
5KJ2 A 1306 - 1612 Jmol OpenAstexViewer
1307 - 1612 5LKT A 1229 - 1612 Jmol OpenAstexViewer
5LKU A 1229 - 1612 Jmol OpenAstexViewer
5LKX A 1229 - 1612 Jmol OpenAstexViewer
5LKZ A 1229 - 1612 Jmol OpenAstexViewer
zf-TAZ 1735 - 1806 2K8F A 13 - 84 Jmol OpenAstexViewer
2MH0 B 1735 - 1806 Jmol OpenAstexViewer
2MZD A 13 - 84 Jmol OpenAstexViewer
3IO2 A 1735 - 1806 Jmol OpenAstexViewer
3P57 P 13 - 84 Jmol OpenAstexViewer
3T92 A 13 - 84 Jmol OpenAstexViewer
338 - 414 1L3E B 116 - 192 Jmol OpenAstexViewer
1P4Q B 116 - 192 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.