Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAD17_HUMAN (Q12864)

Summary

This is the summary of UniProt entry CAD17_HUMAN (Q12864).

Description: Cadherin-17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 832 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 3 17
disorder n/a 127 134
Pfam Cadherin 131 235
disorder n/a 146 151
disorder n/a 190 198
disorder n/a 210 211
disorder n/a 225 226
Pfam Cadherin 243 331
disorder n/a 244 247
disorder n/a 249 252
disorder n/a 256 261
disorder n/a 293 295
disorder n/a 340 347
Pfam Cadherin 345 440
disorder n/a 358 367
disorder n/a 375 376
Pfam Cadherin 456 558
Pfam Cadherin 571 657
low_complexity n/a 641 652
transmembrane n/a 785 808
low_complexity n/a 788 806
disorder n/a 821 823

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q12864. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ
50
51
FKANPPAVTF ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD
100
101
ANGIIVEGPV PITIKVKDIN DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA
150
151
TDLDDPATPN GQLYYQIVIQ LPMINNVMYF QINNKTGAIS LTREGSQELN
200
201
PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK APKPVEMVEN
250
251
STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR
300
301
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ
350
351
ENERLGNSIG TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA
400
401
GMLQLAKQSL KKQDTPQYNL TIEVSDKDFK TLCFVQINVI DINDQIPIFE
450
451
KSDYGNLTLA EDTNIGSTIL TIQATDADEP FTGSSKILYH IIKGDSEGRL
500
501
GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV FGVKYNASSF
550
551
AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY
600
601
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV
650
651
SEFHLILMDV NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG
700
701
PHFTFSLGSG SLQNDWEVSK INGTHARLST RHTEFEEREY VVLIRINDGG
750
751
RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT GIPTVGMAVG ILLTTLLVIG
800
801
IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS                   
832
 

Show the unformatted sequence.

Checksums:
CRC64:2707547DD2DB4202
MD5:550d7a557ebee4cdbe03dff8721a4fb2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cadherin 131 - 235 6ULM A 109 - 213 Show 3D Structure View in InterPro
B 109 - 213 Show 3D Structure View in InterPro
7CYM A 131 - 235 Show 3D Structure View in InterPro
B 131 - 235 Show 3D Structure View in InterPro
7EV1 A 131 - 235 Show 3D Structure View in InterPro
B 131 - 235 Show 3D Structure View in InterPro
243 - 331 7CYM A 243 - 331 Show 3D Structure View in InterPro
B 243 - 331 Show 3D Structure View in InterPro
345 - 440 7CYM A 345 - 440 Show 3D Structure View in InterPro
B 345 - 440 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;