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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ANK3_HUMAN (Q12955)

Summary

This is the summary of UniProt entry ANK3_HUMAN (Q12955).

Description: Ankyrin-3 {ECO:0000303|PubMed:7836469}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 4377 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 46
low_complexity n/a 23 39
Pfam Ank_2 46 137
Pfam Ank_2 129 202
Pfam Ank_2 196 267
disorder n/a 204 205
low_complexity n/a 216 228
disorder n/a 221 222
Pfam Ank_2 259 331
disorder n/a 304 305
Pfam Ank_2 326 397
Pfam Ank_2 389 463
disorder n/a 454 470
Pfam Ank_2 462 529
disorder n/a 496 498
disorder n/a 500 502
Pfam Ank_2 503 594
disorder n/a 530 538
Pfam Ank_2 569 661
disorder n/a 600 601
Pfam Ank_4 665 717
Pfam Ank_2 668 760
disorder n/a 760 770
disorder n/a 778 780
disorder n/a 793 796
low_complexity n/a 817 829
disorder n/a 822 890
low_complexity n/a 904 921
Pfam ZU5 985 1083
low_complexity n/a 992 1005
disorder n/a 1001 1004
disorder n/a 1006 1008
disorder n/a 1033 1035
disorder n/a 1040 1044
disorder n/a 1088 1095
disorder n/a 1099 1111
disorder n/a 1147 1154
disorder n/a 1214 1218
disorder n/a 1221 1234
Pfam UPA_2 1308 1438
disorder n/a 1438 1457
disorder n/a 1482 1485
low_complexity n/a 1516 1538
disorder n/a 1517 1528
disorder n/a 1535 1540
disorder n/a 1554 1555
disorder n/a 1606 1608
disorder n/a 1615 1620
disorder n/a 1625 1627
disorder n/a 1631 1642
disorder n/a 1644 1646
low_complexity n/a 1669 1688
low_complexity n/a 1745 1762
low_complexity n/a 1801 1827
disorder n/a 1856 1857
disorder n/a 1861 1871
low_complexity n/a 1881 1897
disorder n/a 1899 1902
disorder n/a 1913 1944
disorder n/a 1967 2021
low_complexity n/a 1970 1984
low_complexity n/a 1993 2008
disorder n/a 2049 2096
disorder n/a 2102 2103
disorder n/a 2107 2161
disorder n/a 2163 2353
disorder n/a 2356 2363
disorder n/a 2376 2434
low_complexity n/a 2386 2400
disorder n/a 2451 2452
disorder n/a 2474 2507
disorder n/a 2529 2530
disorder n/a 2541 2544
disorder n/a 2555 2560
disorder n/a 2570 2579
disorder n/a 2582 2584
disorder n/a 2588 2590
disorder n/a 2592 2636
low_complexity n/a 2621 2630
disorder n/a 2643 2714
disorder n/a 2719 2750
disorder n/a 2770 2775
disorder n/a 2782 2789
disorder n/a 2791 2832
disorder n/a 2835 2838
disorder n/a 2852 2904
disorder n/a 2908 2918
disorder n/a 2939 2968
disorder n/a 2971 2973
disorder n/a 2975 2978
disorder n/a 2981 2982
disorder n/a 2986 2987
low_complexity n/a 2988 3001
disorder n/a 2990 3012
disorder n/a 3033 3083
disorder n/a 3116 3120
disorder n/a 3127 3327
low_complexity n/a 3136 3147
low_complexity n/a 3196 3210
disorder n/a 3329 3332
disorder n/a 3334 3440
low_complexity n/a 3343 3354
disorder n/a 3445 3447
disorder n/a 3457 3508
low_complexity n/a 3474 3494
disorder n/a 3515 3516
disorder n/a 3539 3835
low_complexity n/a 3575 3589
low_complexity n/a 3586 3599
low_complexity n/a 3784 3790
disorder n/a 3837 3847
disorder n/a 3850 3895
disorder n/a 3909 3912
disorder n/a 3917 3918
disorder n/a 3920 3922
disorder n/a 3924 3981
low_complexity n/a 3955 3981
disorder n/a 4010 4091
coiled_coil n/a 4011 4031
Pfam Death 4091 4174
disorder n/a 4191 4200
disorder n/a 4203 4206
disorder n/a 4208 4211
disorder n/a 4220 4221
disorder n/a 4223 4225
disorder n/a 4227 4228
disorder n/a 4234 4236
disorder n/a 4244 4245
disorder n/a 4248 4309
disorder n/a 4314 4377
low_complexity n/a 4344 4358

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q12955. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR
50
51
AGHLEKALDY IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV
100
101
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
150
151
NHLEVVKFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
200
201
VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH IAAHYGNINV
250
251
ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
300
301
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV
350
351
QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG
400
401
FTPLHIACKK NRIKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS
450
451
QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ
500
501
TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA REGHEDVAAF
550
551
LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT
600
601
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL
650
651
LEYGADANAV TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP
700
701
LHLAAQEDRV NVAEVLVNQG AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL
750
751
QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN VLLQNNASPN ELTVNGNTAL
800
801
GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM NEVLDMSDDE
850
851
VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE
900
901
GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT
950
951
FTREFDSDSL RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS
1000
1001
RHHGMRIIIP PRKCTAPTRI TCRLVKRHKL ANPPPMVEGE GLASRLVEMG
1050
1051
PAGAQFLGPV IVEIPHFGSM RGKERELIVL RSENGETWKE HQFDSKNEDL
1100
1101
TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI KQESNQIGPE
1150
1151
GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS
1200
1201
PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG
1250
1251
GTSPAQWEDI TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ
1300
1301
LYRELICVPY MAKFVVFAKM NDPVESSLRC FCMTDDKVDK TLEQQENFEE
1350
1351
VARSKDIEVL EGKPIYVDCY GNLAPLTKGG QQLVFNFYSF KENRLPFSIK
1400
1401
IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK KETESDQDDE
1450
1451
IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST
1500
1501
RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK
1550
1551
STLGASTTSS VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA
1600
1601
RAPAVTEATP LKGLASNSTF SSRTSPVTTA GSLLERSSIT MTPPASPKSN
1650
1651
INMYSSSLPF KSIITSAAPL ISSPLKSVVS PVKSAVDVIS SAKITMASSL
1700
1701
SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT LQEKISSATN
1750
1751
SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL
1800
1801
YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA
1850
1851
ALLSPIKTLT TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE
1900
1901
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ PELPKEGRID DEEPFKIVEK
1950
1951
VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD KGHSPEDDWI EFSSEEIREA
2000
2001
RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND IGSSSLTNLK
2050
2051
YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD
2100
2101
SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK
2150
2151
PLFHEVPIPP VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF
2200
2201
MELEPKPTTS SIKEKVKAFQ MKASSEEDDH NRVLSKGMRV KEETHITTTT
2250
2251
RMVYHSPPGG EGASERIEET MSVHDIMKAF QSGRDPSKEL AGLFEHKSAV
2300
2301
SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA EPTEVIIRET
2350
2351
KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE
2400
2401
ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD
2450
2451
DELSELRGES YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK
2500
2501
RSREKIATAP KKEILSKIYK DVSENGVGKV SKDEHFDKVT VLHYSGNVSS
2550
2551
PKHAMWMRFT EDRLDRGREK LIYEDRVDRT VKEAEEKLTE VSQFFRDKTE
2600
2601
KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL ASNDEWVKAR
2650
2651
QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA
2700
2701
PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK
2750
2751
IQESKLPVYQ VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV
2800
2801
VNDSGSDNVK KQRTEMSSKA MPDSFSEQQA KDLACHITSD LATRGPWDKK
2850
2851
VFRTWESSGA TNNKSQKEKL SHVLVHDVRE NHIGHPESKS VDQKNEFMSV
2900
2901
TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH PGGLLDQPSR
2950
2951
RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS
3000
3001
KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD
3050
3051
SLEFSPGKES PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ
3100
3101
VGKQYEKEIQ QGGVKKIISQ ECKTVQETRG TFYTTRQQKQ PPSPQGSPED
3150
3151
DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE FTSKTPDSLI AYIPGKPSPI
3200
3201
PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS NQRPKNNRVA
3250
3251
YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI
3300
3301
RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS
3350
3351
AEKASNQKEL ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT
3400
3401
AEFSHDTDAT EIDSLDGYDL QDEDDGLTES DSKLPIQAME IKKDIWNTEG
3450
3451
ILKPADRSFS QSKLEVIEEE GKVGPDEDKP PSKSSSSEKT PDKTDQKSGA
3500
3501
QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL DFDPWSNNRG
3550
3551
DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP
3600
3601
FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD
3650
3651
KSMVTATPQP QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG
3700
3701
SLEKSAAATN TSKVDPKLRT PIKMGISAST MTMKKEGPGE ITDKIEAVMT
3750
3751
SCQGLENETI TMISNTANSQ MGVRPHEKHD FQKDNFNNNN NLDSSTIQTD
3800
3801
NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV RDKQKVLGEQ
3850
3851
QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA
3900
3901
LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL
3950
3951
PVKVRSTCVT TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF
4000
4001
KGISGETLKL VDRLSEEEKK MQSELSDEEE STSRNTSLSE TSRGGQPSVT
4050
4051
TKSARDKKTE AAPLKSKSEK AGSEKRSSRR TGPQSPCERT DIRMAIVADH
4100
4101
LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK WVTRDGKNAT
4150
4151
TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW
4200
4201
QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA
4250
4251
NGSHTEITPE AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL
4300
4301
AAYQKSLEET SKLIIEETKP CVPVSMKKMS RTSPADGKPR LSLHEEEGSS
4350
4351
GSEQKQGEGF KVKTKKEIRH VEKKSHS                         
4377
 

Show the unformatted sequence.

Checksums:
CRC64:F6F9FABD09F15C13
MD5:f504b1ca76834bbf2afb64ae60f85362

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Death 4091 - 4174 4O6X A 5 - 88 Jmol OpenAstexViewer
B 5 - 88 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.